Gastrointestinal Pathology Practice Questions

Q: Acinic cell carcinomas of the salivary gland arise most often in which location?

Parotid salivary gland. **Explanation:** Acinic cell carcinoma (ACC) is a unique salivary gland malignancy characterized by cells showing serous acinar differentiation (containing zymogen granules). **1. Why Parotid Salivary Gland is Correct:** The **parotid gland** is the most common site for acinic cell carcinoma, accounting for approximately **80% to 90%** of all cases [1]. This is because the parotid gland is predominantly composed of serous acini, and ACC is a tumor that recapitulates these serous cells. It is the second most common malignant salivary gland tumor in children (after mucoepidermoid carcinoma) and the third most common overall in adults. **2. Why Other Options are Incorrect:** * **Minor Salivary Glands:** While ACC can occur here (most commonly in the buccal mucosa or lips), it is significantly less frequent than in the parotid. * **Submandibular & Sublingual Glands:** These glands are mixed (seromucous) or predominantly mucous. Primary malignancies in these glands are more likely to be Adenoid Cystic Carcinoma or Mucoepidermoid Carcinoma rather than Acinic Cell Carcinoma. **High-Yield NEET-PG Pearls:** * **Bilateralism:** Acinic cell carcinoma is the most common malignant salivary gland tumor to present **bilaterally** (though Warthin tumor is the most common benign tumor to do so). * **Histology:** Look for "clear cells" or "granular basophilic cytoplasm" (due to zymogen granules). It often stains positive with **PAS (Periodic Acid-Schiff)** and is diastase-resistant. * **Prognosis:** It is generally considered a low-grade malignancy with a relatively favorable prognosis compared to other salivary carcinomas [1]. * **Grading:** Unlike many cancers, its histological appearance does not always correlate with clinical behavior. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Head and Neck, pp. 753-755.

Question 1

Helicobacter pylori infection is associated with an increased risk of which of the following conditions, except?

Accepted Answer

Adenocarcinoma of the esophagus

Answer

Peptic ulcer disease

Answer

Gastric lymphoma

Answer

Antral gastric carcinoma

Question 2

Strong correlation with colorectal cancer is seen in which of the following conditions?

Accepted Answer

Familial polyposis coli

Answer

Peutz-Jeghers polyp

Answer

Juvenile polyposis

Answer

Hyperplastic polyp

Question 3

Which of the following is a precancerous condition of cancer of the stomach?

Accepted Answer

Chronic gastric atrophy

Answer

Peptic ulcer

Answer

Achalasia cardia

Answer

Curling's ulcer

Question 4

A 30-year-old male is diagnosed with Peutz-Jeghers syndrome. What findings are consistent with the diagnosis?

Accepted Answer

Hamartomas

Answer

Adenomas

Answer

Adenomatous polyps

Answer

Villoglandular polyps

Question 5

Helicobacter pylori causes all of the following except:

Accepted Answer

Carcinoid tumor

Answer

Peptic ulcer

Answer

MALToma

Answer

Gastric carcinoma

Question 6

Which of the following statements about Xanthogranulomatous is not true?

Accepted Answer

Associated with tuberculosis

Answer

Foam cells are seen

Answer

Yellow nodules are seen

Answer

Giant cells may be seen

Question 7

Acinic cell carcinomas of the salivary gland arise most often in which location?

Accepted Answer

Parotid salivary gland

Answer

Minor salivary glands

Answer

Submandibular salivary gland

Answer

Sublingual salivary gland

Question 8

Familial polyposis coli is due to which of the following?

Accepted Answer

Abnormality of chromosome 5

Answer

Abnormality of chromosomes

Answer

Intestinal tuberculosis

Answer

Intussusception

Question 9

In chronic inflammation confined to the portal tract with intact limiting membrane and normal lobular parenchyma, what would be the histopathological diagnosis?

Accepted Answer

Chronic persistent hepatitis

Answer

Active hepatitis

Answer

Chronic active hepatitis

Answer

Alcoholic hepatitis

Question 10

All of the following are pre-malignant conditions except:

Accepted Answer

Peutz-Jeghers syndrome

Answer

Crohn's disease

Answer

Ulcerative colitis

Answer

Barrett's esophagus

Gastrointestinal Pathology — MCQs

Gastrointestinal Pathology — MCQs

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