Gastrointestinal Pathology Practice Questions

Q: What is the most common site for leiomyoma in the gastrointestinal tract?

Stomach. **Explanation:** **Leiomyomas** are benign smooth muscle tumors that can occur anywhere in the gastrointestinal (GI) tract where smooth muscle is present. **Why the Stomach is Correct:** The **stomach** is the most common site for leiomyomas in the GI tract, followed by the esophagus. They typically arise from the *muscularis propria* or *muscularis mucosae*. While GISTs (Gastrointestinal Stromal Tumors) were historically misclassified as leiomyomas, true leiomyomas are still most frequently identified in the gastric wall during endoscopic or histological examinations. **Why Other Options are Incorrect:** * **Appendix:** Leiomyomas are extremely rare in the appendix; the most common mesenchymal tumor here is the neuroma, and the most common primary tumor is the carcinoid (neuroendocrine) tumor. * **Jejunum and Ileum:** While smooth muscle tumors occur in the small intestine, they are significantly less common than in the stomach. In the small bowel, GISTs are more prevalent than true leiomyomas [1]. **High-Yield Clinical Pearls for NEET-PG:** * **Histology:** Leiomyomas consist of bundles of spindle-shaped cells with "cigar-shaped" nuclei and no significant atypia or mitotic activity. * **Immunohistochemistry (IHC):** True leiomyomas are **SMA (Smooth Muscle Actin) positive** and **Desmin positive**, but **CD117 (c-KIT) and DOG-1 negative** (this distinguishes them from GISTs) [1]. * **Most common mesenchymal tumor of the GI tract:** GIST (not leiomyoma) [1]. * **Most common site for GIST:** Stomach (60%) [1]. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Gastrointestinal Tract, pp. 783-784.

Question 1

What is the histopathological finding of gluten hypersensitivity?

Accepted Answer

Crypt hyperplasia

Answer

Increase in thickness of the mucosa

Answer

Distal intestine involvement

Answer

Villous hypertrophy

Question 2

What is the most common site for leiomyoma in the gastrointestinal tract?

Accepted Answer

Stomach

Answer

Appendix

Answer

Jejunum

Answer

Ileum

Question 3

Pseudomyxoma peritonei is most commonly associated with which of the following?

Accepted Answer

Mucinous cystadenocarcinoma of the ovary

Answer

Carcinoid tumor of the appendix

Answer

Endometrial carcinoma

Answer

Ileal carcinoid tumor

Question 4

Skip lesions are seen in which of the following conditions?

Accepted Answer

Crohn's disease

Answer

Ulcerative colitis

Answer

Typhoid

Answer

Tuberculosis

Question 5

True about primary gastric lymphoma is

Accepted Answer

H. pylori infection increases the risk

Answer

Affects young adults

Answer

Surgery is never indicated

Answer

T cell lymphoma

Gastrointestinal Pathology — MCQs

Gastrointestinal Pathology — MCQs

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