Bone and Soft Tissue Pathology Practice Questions

Q: Which of the following statements is FALSE regarding ossifying fibroma?

Maxilla is affected more frequently than the mandible. **Explanation:** Ossifying fibroma is a benign fibro-osseous neoplasm of the jaw characterized by the replacement of normal bone with fibrous tissue containing mineralized products. **Why Option B is the Correct (False) Statement:** In ossifying fibroma, the **mandible is affected much more frequently than the maxilla** (ratio of approximately 2:1 or higher). The molar and premolar regions of the mandible are the most common sites of involvement. Therefore, the statement that the maxilla is affected more frequently is incorrect. **Analysis of Other Options:** * **Option A:** It typically affects adults in their **third and fourth decades** of life, with a significant predilection for females. * **Option C:** Radiographically, it appears as a well-demarcated, **circumscribed lesion**. Depending on the degree of calcification, it can range from radiolucent to a mixed "ground-glass" **radiopacity**. Its well-defined borders help differentiate it from fibrous dysplasia [1]. * **Option D:** Unlike fibrous dysplasia (which often stabilizes after puberty) [1], ossifying fibroma is a true neoplasm that **exhibits continuous, slow growth**, potentially causing significant bone expansion and facial asymmetry if left untreated. **NEET-PG High-Yield Pearls:** * **Differential Diagnosis:** The most important distinction is from **Fibrous Dysplasia**. Ossifying fibroma is well-circumscribed (easy to "shell out" surgically), whereas fibrous dysplasia blends into the surrounding bone (orange-peel appearance) [1]. * **Histology:** Features a cellular fibrous stroma with varying amounts of bony trabeculae or cementum-like spherules. * **Treatment:** Surgical enucleation or curettage is the treatment of choice due to its well-defined margins. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Bones, Joints, and Soft Tissue Tumors, p. 1208.

Question 1

Which of the following are synovial sarcoma cellular markers?

Accepted Answer

Cytokeratin

Answer

S-100

Answer

Vimentin

Answer

Calretinin

Question 2

Marble bone disease, characterized by increased bone density, is due to a mutation in the gene encoding which of the following enzymes?

Accepted Answer

Carbonic anhydrase II

Answer

Carbonic anhydrase I

Answer

Carbonic anhydrase III

Answer

Carbonic anhydrase IV

Question 3

Shell teeth are more common in which variant of dentinogenesis imperfecta?

Accepted Answer

Type II

Answer

Type I

Answer

Type III

Answer

Type III and I

Question 4

Which of the following statements is FALSE regarding ossifying fibroma?

Accepted Answer

Maxilla is affected more frequently than the mandible

Answer

Affects individuals in the third to fourth decade of life

Answer

Presents as a circumscribed radiopacity

Answer

Exhibits continuous growth

Question 5

What percentage of giant cell tumors of bone are malignant?

Accepted Answer

5 - 10%

Answer

15 - 20%

Answer

25 - 30%

Answer

50 - 60%

Question 6

Alpha-1 antitrypsin deficiency is associated with all of the following except?

Accepted Answer

Renal disease

Answer

Fatty liver

Answer

Emphysema

Answer

Pancreatitis

Question 7

Sarcoma botryoides is a type of?

Accepted Answer

Rhabdomyosarcoma

Answer

Rhabdomyoma

Answer

Lymphangioma

Answer

Leiomyoma

Question 8

A bone biopsy in an area involved by Paget's disease is MOST likely to show which of the following histopathological features?

Accepted Answer

Mosaic pattern of lamellar bone

Answer

Benign spindle cells growing in a storiform pattern

Answer

Chondrocalcinosis within a bony medullary cavity

Answer

Spirochetes visible with silver stain

Question 9

Cherubism is a term used for which of the following conditions?

Accepted Answer

Familial form of fibrous dysplasia of the jaw

Answer

Osteoclastoma of the jaw

Answer

Exostosis of the midline of the palate

Answer

None of the above

Question 10

In rheumatoid arthritis pathology, what are the characteristic changes?

Accepted Answer

Synovium

Answer

Articular cartilage

Answer

Capsule

Answer

Muscle

Bone and Soft Tissue Pathology — MCQs

Bone and Soft Tissue Pathology — MCQs

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