Bone and Soft Tissue Pathology — MCQs

Severe laxity of joints is a characteristic feature of which of the following conditions?

Predominant osteoblastic secondaries are seen in which of the following malignancies?

Histopathologically, reversal lines are seen in which of the following conditions?

A 55-year-old man presents with a five-month history of left thigh pain. Physical examination reveals the left thigh to be increased in size compared to the right. A plain film radiograph shows a 15 cm solid mass with infiltrative margins, not appearing to arise from bone. A biopsy of this mass reveals highly pleomorphic spindle cells on microscopic examination. Which of the following markers is most likely to be demonstrated in the cells of this mass?

MIC-2 is a marker of which condition?

A 10-year-old girl presents with a tibial mass. Histopathological examination reveals a small round cell tumor. Which of the following molecular findings is most likely to be present?

A non-neoplastic hereditary bone lesion, histologically similar to central giant cell granuloma, affects children and shows a bilateral involvement of the jaws with 'eye to heaven' appearance clinically. What is this condition?

Recurrent fibroma is a term that refers to a Desmoid tumor arising in which location?

According to Dardick's multicellular theory, which type of cells are NOT responsible for the origin of pleomorphic adenoma?

A 74-year-old woman presents with insidious onset of increasing back pain and malaise without a history of recent trauma. Her past medical history includes hypertension and breast cancer diagnosed 7 years ago, treated with surgery and adjuvant therapy. Physical examination reveals percussion tenderness over the lower spine. An X-ray of the lumbar spine shows lytic lesions compatible with metastatic bone disease, and her serum calcium level is elevated. Which of the following mediators is least likely to be involved in this patient's presentation?