Gynecological Disorders Practice Questions

Q: Which of the following statements about Asherman's syndrome is true?

Characterized by intrauterine adhesions. ***Characterized by intrauterine adhesions*** - **Asherman's syndrome** is fundamentally defined by the presence of **intrauterine adhesions** or scarring of the uterine cavity. - These adhesions develop following trauma to the basal layer of the endometrium, often from gynecological procedures like **dilation and curettage (D&C)**. - This is the **pathognomonic feature** that defines the syndrome. *Progesterone challenge test is positive* - The **progesterone challenge test** assesses the presence of an intact endometrium and adequate estrogen priming. - In Asherman's syndrome, due to the scarred endometrium, the response to progesterone is typically **absent or minimal**, leading to a **negative** result. - A negative progesterone challenge test indicates outflow obstruction or endometrial non-responsiveness. *May be secondary to TB* - While **genital tuberculosis** can cause intrauterine adhesions and is a recognized etiology, it represents a **small minority** of cases. - The primary etiology of Asherman's syndrome is usually **iatrogenic**, following uterine instrumentation such as D&C, particularly post-partum or post-abortion. - TB-related adhesions may have additional features like caseating granulomas. *Not associated with menstrual irregularities* - This is **false** - Asherman's syndrome is classically associated with **menstrual irregularities**. - Common presentations include **hypomenorrhea** (scanty periods), **amenorrhea** (absent periods), or oligomenorrhea. - These menstrual changes result from the reduced functional endometrium available for cyclical shedding due to intrauterine adhesions.

Q: What is the definitive management for adenomyosis?

Hysterectomy (surgical removal of the uterus).. ***Hysterectomy (surgical removal of the uterus)*** - This is considered the **definitive management** for adenomyosis because it completely removes the uterine tissue where the ectopic endometrial glands are found. - Hysterectomy effectively eliminates the source of symptoms such as **heavy menstrual bleeding** and **pelvic pain** by removing the uterus entirely. *Endometrial ablation* - Endometrial ablation involves destroying the **lining of the uterus** and is primarily used for heavy menstrual bleeding. - It is **ineffective for adenomyosis** since the endometrial tissue is embedded deep within the myometrium and is not fully reached by ablation. *Hormonal therapy (e.g., Danazol) for temporary symptom relief* - **Danazol** (an androgen derivative) can suppress ovarian function and reduce symptoms of adenomyosis by shrinking endometrial tissue. - However, its effects are **temporary**, and symptoms typically return upon cessation of treatment, making it not a definitive solution. *Hormonal therapy (e.g., GNRH analogue) for temporary symptom relief* - **GnRH analogues** induce a temporary menopausal state, which can significantly reduce symptoms by inhibiting estrogen production, leading to atrophy of the adenomyotic tissue. - This treatment is also **temporary**, and symptoms often recur once the medication is stopped; it's often used as a bridge to surgery or for women nearing menopause.

Q: Commonest fungal infection of the female genitalia in diabetes is?

Candidal. ***Candidal*** - **Candida albicans** is the most common cause of fungal infections, particularly **vulvovaginal candidiasis**, in diabetic women due to high glucose levels providing a favorable environment for fungal growth. - Diabetes leads to **immunosuppression** and elevated vaginal glycogen, both of which promote Candida proliferation. *Cryptococcal* [1] - **Cryptococcus neoformans** primarily causes infections in immunocompromised individuals, typically affecting the **lungs** and **central nervous system**, not the genitalia. - Genital cryptococcosis is exceedingly rare and usually a manifestation of disseminated disease, not a common primary infection. *Madura mycosis* - **Madura mycosis** (also known as mycetoma) is a chronic, localized infection of the **skin and subcutaneous tissue**, usually affecting the feet, and is caused by certain fungi or bacteria. - It is not a common cause of genital infection, even in diabetic patients, and is typically associated with **traumatic inoculation in tropical regions**. *Aspergellosis* - **Aspergillus** species typically cause respiratory infections (e.g., **aspergilloma**, **invasive aspergillosis**) mainly in immunocompromised patients. - Genital involvement is extremely rare and usually occurs as part of **disseminated disease**, not as a common primary infection in diabetic women.

Q: Which of the following is a criterion used in the classification of endometriosis according to the ASRM classification?

Size of lesions. ***Size of lesions*** - The **ASRM (American Society for Reproductive Medicine) classification** system for endometriosis primarily relies on the **size of peritoneal implants**, ovarian endometriomas, and the extent of adhesions. - This criterion is crucial for assigning a **score** that contributes to determining the stage of endometriosis (minimal, mild, moderate, or severe). *Number of lesions* - While the number of lesions is observed during surgical evaluation, it is **not a primary independent criterion** used to assign a specific score in the ASRM classification. - The scoring focuses more on the **size and depth** of individual lesions rather than a simple count. *Severity of lesions* - The term "severity of lesions" is **too broad** to be a distinct criterion in the ASRM classification. - The classification assesses specific characteristics like **size and depth of implants** to collectively determine the overall severity (stage) of endometriosis, rather than using severity itself as a measurable criterion. *Anatomical location of lesions* - The ASRM classification **does consider anatomical location** (e.g., peritoneum, ovaries, deep infiltrative sites) but not as a stand-alone, independent criterion for scoring in the same way as implant size. - While essential for charting and acknowledging the presence of lesions, the **scoring mechanism** directly assigns points based on features like **size and depth** at these locations, not just the location itself.

Q: Which of the following is NOT a risk factor for malignant transformation of an endometrial polyp?

Use of oral contraceptives. ***Use of oral contraceptives*** - **Oral contraceptives** are not considered a risk factor for malignant transformation of endometrial polyps; in fact, they may be protective against endometrial hyperplasia and cancer. - Their progestin component induces endometrial atrophy, counteracting potential proliferative effects. *Large polyp > 1.5 cm size* - **Larger polyp size**, typically defined as >1.5 cm, is associated with a higher likelihood of malignant transformation. - Larger polyps have a greater chance of containing atypical histology or cancerous foci. *Abnormal uterine bleeding* - **Abnormal uterine bleeding (AUB)**, especially postmenopausal bleeding, is a common symptom of endometrial polyps and also a significant risk factor for malignancy within a polyp. - AUB warrants investigation to rule out endometrial carcinoma, which can arise within a polyp. *Use of tamoxifen* - **Tamoxifen**, a selective estrogen receptor modulator used in breast cancer treatment, has estrogenic effects on the endometrium, increasing the risk of endometrial polyps, hyperplasia, and cancer. - The use of tamoxifen is a well-established risk factor for both the development of polyps and their malignant transformation.

Q: Which of the following is not a complication of pelvic inflammatory disease?

Pyometra. ***Pyometra*** - **Pyometra** is a collection of pus in the uterine cavity, typically caused by cervical stenosis (from surgery, radiation, or postmenopausal atrophy) or cervical malignancy, and is **not a recognized complication of Pelvic Inflammatory Disease (PID)**. - While PID involves ascending infection causing **endometritis** (inflammation of the endometrial lining), it does not typically lead to pyometra, which requires obstruction at the cervical level. - Pyometra is not listed among standard PID complications in major obstetrics and gynecology textbooks. *Ectopic pregnancy* - **Ectopic pregnancy** is a well-recognized complication of PID due to damage and scarring of the **fallopian tubes**, which impairs the normal transit of a fertilized egg to the uterus. - The inflammation and adhesions caused by PID create an environment that can trap the embryo outside the uterus, most commonly in the fallopian tube. - Risk of ectopic pregnancy increases 6-10 fold after PID. *Infertility* - **Infertility** is a common long-term consequence of PID, resulting from scarring and damage to the fallopian tubes, ovaries, and surrounding structures. - Tubal factor infertility occurs in approximately 10-20% of women after one episode of PID, with the risk increasing with recurrent infections. - This damage can obstruct the passage of eggs and sperm, or impair tubal function necessary for conception. *Endometritis* - **Endometritis** is an inflammation of the lining of the uterus and is a **direct component** of PID, not just a complication. - PID involves the ascension of infection from the cervix through the endometrium to the fallopian tubes and potentially to the ovaries and peritoneum. - Endometritis represents the uterine involvement in the spectrum of upper genital tract infection that defines PID.

Q: Endosalpingitis is best diagnosed by?

laparoscopy. ***Laparoscopy*** - **Laparoscopy** is the **gold standard** for diagnosing endosalpingitis as it allows direct visualization of the fallopian tubes, pelvic organs, and peritoneal cavity. - It enables identification of **inflammation, adhesions, tubal edema, and purulent exudate** characteristic of endosalpingitis. - It also permits **tissue sampling** for histopathological confirmation and culture of infectious agents. - Laparoscopy has high sensitivity and specificity for diagnosing pelvic inflammatory disease (PID) and its complications. *X-Ray abdomen* - An **X-ray abdomen** provides limited information regarding soft tissue structures like the fallopian tubes. - It is primarily used for visualizing bones or detecting gross abnormalities like bowel obstruction or free air. - It **cannot directly diagnose endosalpingitis** or provide detailed images of adnexal structures. *Hysterosalpingography* - **Hysterosalpingography (HSG)** is an imaging technique used to assess the patency and contour of the fallopian tubes and uterine cavity by injecting contrast dye. - While it can detect **tubal occlusion or hydrosalpinx**, it cannot visualize external tubal inflammation, adhesions, or the peritoneal surface. - HSG is more useful for evaluating **tubal patency in infertility workup** rather than diagnosing acute inflammation. *Hystero-laparoscopy* - This term refers to **combined hysteroscopy and laparoscopy** performed together. - While the laparoscopic component can diagnose endosalpingitis, **hysteroscopy** (visualization of the uterine cavity) adds no additional value for diagnosing tubal inflammation. - For endosalpingitis specifically, **laparoscopy alone** is sufficient and is the most direct diagnostic approach.

Q: Ulceration of the vulva is commonly seen in all except:

Bacterial vaginosis. ***Bacterial vaginosis*** - This condition is characterized by an imbalance of vaginal flora, leading to a thin, *fishy-smelling discharge* and *vulvar irritation*, but *not ulceration*. - It does *not typically cause vulvar lesions* or ulcers, which are more common in sexually transmitted infections (STIs) or inflammatory conditions. *Syphilis* - **Primary syphilis** classically presents with a *painless chancre*, which is a firm, indurated ulcer, commonly found on the vulva. - The ulcer is highly infectious and is a hallmark of the early stage of the disease. *Chancroid* - Caused by *Haemophilus ducreyi*, chancroid is characterized by *painful, ragged-edged ulcers* on the vulva. - These *ulcers* are often accompanied by *tender inguinal lymphadenopathy* that can progress to *buboes*. *Behcet's disease* - This is a chronic inflammatory disorder that causes recurrent *oral and genital ulcers*, including on the vulva. - The *genital ulcers* are often *painful* and can be *scarring*, resembling those seen in *herpes simplex virus* infections.

Q: Which of the following statements is true regarding bacterial vaginosis?

All of these. ***All of these*** - **Bacterial vaginosis (BV)** is characterized by a **fishy odor discharge**, a **grayish vaginal discharge**, and the presence of **clue cells** on microscopy, making all the other statements true features of the condition. - The combination of these findings is diagnostic of BV, often confirmed using the **Amsel criteria** which include these features. *It is characterized by fishy odour discharge* - A characteristic symptom of **bacterial vaginosis** is a **fishy odor**, especially after intercourse, due to the production of amines by anaerobic bacteria. - While a prominent feature, it is not the sole diagnostic criterion for BV. *It is characterized by grey discharge* - Women with **bacterial vaginosis** often present with a **thin, whitish-gray, homogenous vaginal discharge**. - This discharge is typically adherent to the vaginal walls and may not cause significant irritation. *Clue cells are found on microscopy* - **Clue cells** are **vaginal epithelial cells** covered in bacteria, observable on microscopy, and are considered the **hallmark diagnostic feature of bacterial vaginosis**. - Their presence on a wet mount is a key indicator of the altered vaginal flora.

Q: Most common site for endometriosis in the urinary system is

Bladder. ***Bladder*** - The **bladder** is the most common site for **urinary tract endometriosis**, accounting for approximately 80% of all cases. - This is often due to its anatomical proximity to the uterus and broad ligaments, allowing for easier implantation of **ectopic endometrial tissue**. *Kidney* - **Kidney involvement** in endometriosis is extremely rare and typically occurs only in severe, widespread cases. - It is not considered a common site for endometrial implants in the urinary system. *Ureter - lower segment* - While the **ureter** can be affected by endometriosis, particularly the lower segment, it is less common than bladder involvement. - Ureteral obstruction due to endometriosis can lead to **hydronephrosis**. *Ureter - upper segment* - Endometriosis of the **upper ureter** is very uncommon, with the disease more frequently found in the distal (lower) segments if the ureter is affected at all. - The close anatomical relationship between the **pelvic organs** makes lower urinary tract involvement more likely.

Question 1

Which of the following statements about Asherman's syndrome is true?

Accepted Answer

Characterized by intrauterine adhesions

Answer

May be secondary to TB

Answer

Progesterone challenge test is positive

Answer

Not associated with menstrual irregularities

Question 2

What is the definitive management for adenomyosis?

Accepted Answer

Hysterectomy (surgical removal of the uterus).

Answer

Endometrial ablation.

Answer

Hormonal therapy (e.g., Danazol) for temporary symptom relief.

Answer

Hormonal therapy (e.g., GnRH analogue) for temporary symptom relief.

Question 3

Commonest fungal infection of the female genitalia in diabetes is?

Accepted Answer

Candidal

Answer

Cryptococcal

Answer

Madura mycosis

Answer

Aspergellosis

Question 4

Which of the following is a criterion used in the classification of endometriosis according to the ASRM classification?

Accepted Answer

Size of lesions

Answer

Severity of lesions

Answer

Number of lesions

Answer

Anatomical location of lesions

Question 5

Which of the following is NOT a risk factor for malignant transformation of an endometrial polyp?

Accepted Answer

Use of oral contraceptives

Answer

Abnormal uterine bleeding

Answer

Use of tamoxifen

Answer

Large polyp > 1.5 cm size

Question 6

Which of the following is not a complication of pelvic inflammatory disease?

Accepted Answer

Pyometra

Answer

Ectopic

Answer

Endometritis

Answer

Infertility

Question 7

Endosalpingitis is best diagnosed by?

Accepted Answer

laparoscopy

Answer

X-Ray abdomen

Answer

Hysterosalpingography

Answer

Hystero-laparoscopy

Question 8

Ulceration of the vulva is commonly seen in all except:

Accepted Answer

Bacterial vaginosis

Answer

Chancroid

Answer

Behcet's disease

Answer

Syphilis

Question 9

Which of the following statements is true regarding bacterial vaginosis?

Accepted Answer

All of these

Answer

It is characterized by fishy odour discharge

Answer

It is characterized by grey discharge

Answer

Clue cells are found on microscopy

Question 10

Most common site for endometriosis in the urinary system is

Accepted Answer

Bladder

Answer

Kidney

Answer

Ureter - lower segment

Answer

Ureter - upper segment

Gynecological Disorders — MCQs

Gynecological Disorders — MCQs

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