Contraception and Family Planning Practice Questions

Q: Which of the following liver disorders is a complication associated with oral contraceptives?

Intrahepatic cholestasis. ### Explanation **Correct Answer: D. Intrahepatic cholestasis** **Why it is correct:** Combined Oral Contraceptive Pills (COCPs) contain estrogen and progesterone, which can interfere with the transport of bile acids across the canalicular membrane. Estrogen, in particular, decreases the activity of the bile salt export pump (BSEP), leading to **intrahepatic cholestasis**. This condition mimics "Intrahepatic Cholestasis of Pregnancy" (ICP). Patients typically present with pruritus (often involving palms and soles) and mild jaundice, which resolves upon discontinuation of the pill. **Analysis of Incorrect Options:** * **A. Drug-induced hepatitis with fatty change:** While some drugs cause steatosis, COCPs are more typically associated with cholestasis or specific benign tumors rather than generalized fatty hepatitis. * **B. Cholangiocarcinoma:** There is no established causal link between COCP use and bile duct cancer (cholangiocarcinoma). In fact, some studies suggest COCPs may have a protective effect against certain hepatobiliary cancers. * **C. Cavernous hemangiomas:** These are the most common benign liver tumors but are generally congenital. While they may enlarge during pregnancy due to hormonal sensitivity, they are **not** primarily caused by COCPs. Note: COCPs are strongly associated with **Hepatic Adenomas**, not hemangiomas. **High-Yield Clinical Pearls for NEET-PG:** * **Hepatic Adenoma:** This is the most classic liver tumor associated with long-term COCP use. It carries a risk of rupture and intraperitoneal hemorrhage. * **Contraindications:** According to WHO Medical Eligibility Criteria (MEC), COCPs are **Category 4 (Absolute Contraindication)** in patients with active viral hepatitis, decompensated cirrhosis, or hepatocellular carcinoma. * **Gallstones:** Estrogen increases cholesterol saturation in bile, increasing the risk of cholelithiasis (gallstones) in COCP users.

Q: Which oral contraceptive pill has the least failure rate?

Combined pill. **Explanation:** The **Combined Oral Contraceptive Pill (COCP)** is the most effective oral contraceptive method because it utilizes a dual mechanism of action. It contains both estrogen and progestogen, which work synergistically to **suppress ovulation** by inhibiting the release of FSH and LH from the pituitary gland. When used perfectly, the failure rate is as low as **0.1 per 100 woman-years** (Pearl Index), making it superior to other oral formulations. **Analysis of Options:** * **Combined Pill (Correct):** By consistently inhibiting ovulation and thickening cervical mucus, it provides the highest level of protection among oral options. * **Mini Pill (Progestogen-Only Pill):** These primarily work by thickening cervical mucus and altering the endometrium. Since they do not consistently suppress ovulation in all cycles and have a very narrow "missed pill" window (3 hours for traditional formulations), they have a higher failure rate (approx. 0.3–9.0). * **Sequential Pill:** These were designed to mimic the natural cycle (estrogen followed by estrogen+progesterone). They were found to be less effective than COCPs and carried a higher risk of endometrial cancer; they are largely obsolete in modern practice. **High-Yield Clinical Pearls for NEET-PG:** * **Pearl Index:** The standard measure for contraceptive failure (number of pregnancies per 100 woman-years). * **Most common side effect of COCP:** Breakthrough bleeding (especially in the first 3 months). * **Most serious side effect:** Venous Thromboembolism (VTE), primarily due to the estrogen component. * **Non-contraceptive benefits:** Reduced risk of ovarian and endometrial cancers (protective effect lasts years after discontinuation). * **Drug Interactions:** Enzyme inducers like Rifampicin and Phenytoin decrease the efficacy of OCPs.

Q: An oral contraceptive pill containing progesterone, given in small quantities for 30 days a month, is known as which of the following?

Micro pill. **Explanation:** The correct answer is **Micro pill** (also known as the Progesterone-Only Pill or POP). **1. Why Micro pill is correct:** Micro pills contain a very small dose of progestogen (e.g., Levonorgestrel 30–75 μg or Norethisterone 350 μg) and **no estrogen**. Unlike combined pills, they are taken continuously for **30 days a month** (every day of the cycle) without a break. Their primary mechanism of action is increasing the viscosity of cervical mucus (preventing sperm penetration) and altering the endometrium to make it unfavorable for implantation. Ovulation is inhibited in only about 70–80% of cycles. **2. Why other options are incorrect:** * **Sequential pill:** These were designed to mimic the natural cycle by giving estrogen alone for the first 14–15 days, followed by estrogen plus progesterone for the last 5–6 days. They are no longer used due to an increased risk of endometrial cancer. * **Combined pill:** These contain both estrogen and progestogen. They are typically taken for 21 days followed by a 7-day pill-free (or placebo) interval to allow for withdrawal bleeding. **3. High-Yield Clinical Pearls for NEET-PG:** * **Ideal Candidate:** Micro pills are the contraceptive of choice for **lactating mothers** (as they do not suppress milk production) and women in whom estrogen is contraindicated (e.g., history of DVT, smokers >35 years, or migraine with aura). * **The "3-Hour Rule":** Traditional POPs must be taken at the same time every day; a delay of more than 3 hours is considered a "missed pill." * **Side Effects:** The most common side effect is **irregular menstrual bleeding** or spotting. * **Centchroman (Saheli):** Remember that this is a Non-steroidal, Non-hormonal "Once-a-week" pill (SERM) developed by CDRI, Lucknow.

Q: Oral combined contraceptive pills contain which one of the following sets of hormones?

Progestogen and ethinyl estradiol. **Explanation:** Combined Oral Contraceptive Pills (COCPs) are formulated to mimic the physiological feedback loop of the menstrual cycle to prevent ovulation. The "combined" nature refers to the presence of two specific hormonal components: an **estrogen** and a **progestogen**. 1. **Why Option B is correct:** * **Estrogen Component:** In almost all COCPs, the estrogen used is **Ethinyl Estradiol (EE)**. It provides cycle control by stabilizing the endometrium and inhibits FSH, preventing follicular development. * **Progestogen Component:** This is the primary contraceptive agent. It inhibits LH (preventing the LH surge and ovulation), thickens cervical mucus to block sperm, and thins the endometrium. Common progestogens include Desogestrel, Levonorgestrel, or Drospirenone. 2. **Why other options are incorrect:** * **Estrone (Options A, C, and D):** Estrone (E1) is a weak estrogen primarily produced after menopause. It is not used in standard COCPs because it lacks the potency and pharmacological profile required for effective ovulation suppression. * **Option D:** This option lacks a progestogen. Without progestogen, the pill would not reliably inhibit ovulation or provide the necessary changes to cervical mucus. **High-Yield Clinical Pearls for NEET-PG:** * **Mechanism of Action:** The primary mechanism is the **inhibition of ovulation** via suppression of the Hypothalamic-Pituitary-Ovarian (HPO) axis. * **Standard Dose:** Modern "low-dose" pills typically contain **20–35 µg** of Ethinyl Estradiol. * **Non-Contraceptive Benefits:** COCPs reduce the risk of **Ovarian and Endometrial cancers** (protective effect lasts years after discontinuation). * **Absolute Contraindications:** Undiagnosed vaginal bleeding, history of Thromboembolism (DVT/PE), smokers >35 years old, and active liver disease.

Q: What is the daily quantity of progesterone released?

65 ug. ### Explanation The question refers to the **Mirena (LNG-IUD)**, which is a high-yield topic in NEET-PG. The Mirena is a T-shaped intrauterine device containing 52 mg of Levonorgestrel (a potent progestogen). **1. Why 65 µg is the correct answer:** Initially, upon insertion, the Mirena releases Levonorgestrel at a rate of approximately **65 µg/day** (often cited as 60–65 µg/day in standard textbooks like Williams Gynecology). This high initial release ensures immediate local contraceptive efficacy. However, this rate is not constant; it gradually declines over time to about 30 µg/day after 5 years and roughly 20 µg/day by the end of its typical 7-year lifespan. **2. Analysis of Incorrect Options:** * **A (25 µg) & B (45 µg):** These values are too low for the initial release phase of a standard LNG-IUD. While the release rate eventually drops to these levels after several years of use, they do not represent the standard "initial release" value typically tested. * **D (85 µg):** This value exceeds the standard pharmacological release rate of the Mirena system. A release rate this high would likely increase systemic side effects without providing additional contraceptive benefits. **3. Clinical Pearls for NEET-PG:** * **Mechanism of Action:** Primarily works by thickening cervical mucus and causing endometrial atrophy (foreign body reaction). It does *not* consistently inhibit ovulation. * **Life Span:** Approved for up to **8 years** for contraception (previously 5–7 years). * **Non-Contraceptive Benefit:** It is the **Gold Standard** (Medical Management) for Heavy Menstrual Bleeding (HMB) and is used in the treatment of endometriosis and endometrial hyperplasia. * **Pearl:** Do not confuse this with **Progestasert**, an older progesterone-only IUD that released **65 µg of natural progesterone** daily but had to be replaced every year. Modern exams usually refer to the LNG-IUD (Mirena) unless specified otherwise.

Q: Norplant is:

Subcutaneous implant. **Explanation:** **Norplant** is a long-acting reversible contraceptive (LARC) system consisting of six flexible silastic capsules. It is classified as a **subcutaneous implant** because it is surgically inserted under the skin of the upper arm. Each capsule contains 36 mg of **Levonorgestrel** (a progestogen), which is released at a slow, steady rate to provide contraceptive protection for up to 5 years. Its primary mechanism of action is the suppression of ovulation and thickening of cervical mucus. **Analysis of Options:** * **Option A (Correct):** It is placed in the subdermal layer, making it a subcutaneous implant. * **Option B (Incorrect):** Norplant is a hormonal (steroidal) method. Non-steroidal pills include Centchroman (Saheli). * **Option C (Incorrect):** While it acts as a reservoir, it is a silastic capsule/rod system, not a "depot tablet." Depot formulations usually refer to intramuscular injections like DMPA. * **Option D (Incorrect):** IUCDs (like Cu-T or Mirena) are inserted into the uterine cavity, whereas Norplant is systemic and extra-uterine. **High-Yield Clinical Pearls for NEET-PG:** * **Norplant-2 (Jadelle):** A newer version consisting of only **2 rods**, effective for 5 years. * **Implanon:** A single-rod implant containing **Etonogestrel**, effective for 3 years. * **Failure Rate:** It has one of the lowest failure rates (~0.05%), comparable to surgical sterilization. * **Side Effects:** The most common side effect is **irregular menstrual bleeding** (breakthrough bleeding). * **Contraindication:** Active liver disease, undiagnosed vaginal bleeding, and breast cancer.

Q: A patient gives a history of missing a single dose of her combined oral contraceptive pill. What advice should be given?

Take 2 pills the next day and continue with the course.. **Explanation:** The management of missed Combined Oral Contraceptive Pills (COCPs) is a high-yield topic based on the WHO Medical Eligibility Criteria. **1. Why Option B is Correct:** When a **single pill** is missed (less than 24 hours late) or if 24 to 48 hours have passed since the last pill was taken, the risk of ovulation is minimal. The standard protocol is to **take the missed pill as soon as remembered**, even if it means taking two pills on the same day (the missed one + the scheduled one). The patient should then continue the rest of the pack as usual. In this scenario, back-up contraception (like condoms) is generally not required. **2. Why Incorrect Options are Wrong:** * **Option A:** Ignoring the missed dose increases the risk of "escape ovulation" due to a drop in hormone levels, potentially leading to contraceptive failure. * **Option C:** Taking two pills every day for the remainder of the cycle is unnecessary and would cause significant hormonal side effects (nausea, breast tenderness) without providing additional protection. * **Option D:** Discontinuing the course is only recommended if multiple pills are missed in certain weeks or if the patient prefers to switch methods. For a single missed pill, the cycle can be safely salvaged. **3. Clinical Pearls for NEET-PG:** * **The "7-Day Rule":** If **2 or more pills** are missed (more than 48 hours since the last pill), the patient should take the most recent missed pill, discard other missed pills, and use **back-up contraception for the next 7 days**. * **Emergency Contraception (EC):** If 2+ pills are missed in the **first week** of the pack and unprotected intercourse occurred, EC should be considered. * **Vomiting/Diarrhea:** If severe vomiting occurs within 2 hours of pill intake, it should be treated as a missed dose.

Q: Which of the following is NOT a contraindication for oral contraceptive use?

Being more than 30 years old. **Explanation:** The correct answer is **D. Being more than 30 years old**. Age alone is not a contraindication for Combined Oral Contraceptive (COC) use. According to the WHO Medical Eligibility Criteria (MEC), COCs can be safely used from menarche until age 40. For women over 40, they are generally avoided (MEC Category 2/3) due to increased cardiovascular risks, but age 30 is considered safe for healthy, non-smoking women. **Why the other options are contraindications:** * **Heart Disease (Option A):** COCs contain estrogen, which increases the synthesis of clotting factors and can lead to thromboembolism. They are contraindicated in patients with ischemic heart disease, valvular heart disease with complications, or severe hypertension. * **Epileptic Patient (Option B):** While not a direct medical contraindication for the patient's health, enzyme-inducing anti-epileptic drugs (like Phenytoin, Carbamazepine) increase the metabolism of estrogen, significantly reducing the efficacy of the pill and leading to contraceptive failure. * **Migraine (Option C):** Estrogen can exacerbate migraines. Specifically, migraine with aura is a **Category 4 (Absolute Contraindication)** due to a significantly high risk of ischemic stroke. **High-Yield Clinical Pearls for NEET-PG:** * **Smoking & Age:** Smoking $\geq$15 cigarettes/day in women $\geq$35 years is an absolute contraindication (MEC 4). * **Breast Cancer:** Current breast cancer is an absolute contraindication (MEC 4). * **Liver Disease:** Active viral hepatitis or cirrhosis is a contraindication as the liver metabolizes steroid hormones. * **Beneficial Effects:** COCs reduce the risk of Ovarian and Endometrial cancers (Protective effect).

Q: Oral contraceptive pills act mainly by?

Inhibition of ovulation. **Explanation:** The primary mechanism of action of Combined Oral Contraceptive Pills (COCPs) is the **inhibition of ovulation**. This is achieved through a negative feedback loop on the hypothalamic-pituitary-ovarian axis. The estrogen component suppresses **FSH** (Follicle Stimulating Hormone), preventing follicular development, while the progestogen component suppresses the **LH surge** (Luteinizing Hormone), which is essential for the release of the ovum. **Analysis of Options:** * **Option A:** While COCPs do cause cervical mucus thickening (making it hostile to sperm), this is considered a **secondary** mechanism. It is, however, the primary mechanism for Progestogen-Only Pills (POPs). * **Option C:** Progestogens cause the endometrium to become out of phase (atrophic or secretory), making it unsuitable for implantation. This is a backup mechanism but not the "main" action of COCPs. * **Option D:** This is physiologically incorrect. COCPs do not work by inducing uterine contractions; in fact, progesterone generally has a relaxing effect on the myometrium. **High-Yield Clinical Pearls for NEET-PG:** * **Most potent component:** The progestogen is primarily responsible for the contraceptive effect (LH suppression). * **Estrogen role:** Mainly provides cycle control (prevents breakthrough bleeding) and suppresses FSH. * **Pearl:** For **Mini-pills (POPs)**, the main mechanism is the **cervical mucus plug**, as they do not consistently inhibit ovulation in all cycles. * **Pearl:** The most common side effect of COCPs is breakthrough bleeding, while the most serious risk is venous thromboembolism (VTE).

Question 1

Which of the following liver disorders is a complication associated with oral contraceptives?

Accepted Answer

Intrahepatic cholestasis

Answer

Drug-induced hepatitis with fatty change

Answer

Cholangiocarcinoma

Answer

Cavernous hemangiomas

Question 2

Which oral contraceptive pill has the least failure rate?

Accepted Answer

Combined pill

Answer

Sequential pill

Answer

Mini pill

Answer

None of the above

Question 3

Which method of sterilization is least effective?

Accepted Answer

Hysteroscopic tubal occlusion

Answer

Pomeroy's technique

Answer

Laparoscopy

Answer

Vaginal fimbriectomy

Question 4

An oral contraceptive pill containing progesterone, given in small quantities for 30 days a month, is known as which of the following?

Accepted Answer

Micro pill

Answer

Sequential pill

Answer

Combined pill

Answer

None of the above

Question 5

Oral combined contraceptive pills contain which one of the following sets of hormones?

Accepted Answer

Progestogen and ethinyl estradiol

Answer

Ethinyl estradiol, progestogen, and estrone

Answer

Progestogen and estrone

Answer

Estrone and ethinyl estradiol

Question 6

What is the daily quantity of progesterone released?

Accepted Answer

65 ug

Answer

25 ug

Answer

45 ug

Answer

85 ug

Question 7

Norplant is:

Accepted Answer

Subcutaneous implant

Answer

Non-steroidal PIU

Answer

Depot tablet

Answer

Intrauterine contraceptive device (IUCD)

Question 8

A patient gives a history of missing a single dose of her combined oral contraceptive pill. What advice should be given?

Accepted Answer

Take 2 pills the next day and continue with the course.

Answer

Continue with the course without regard to the missed dose.

Answer

Take 2 pills every day for the remaining part of the course.

Answer

Discontinue the course and use an alternative method of contraception.

Question 9

Which of the following is NOT a contraindication for oral contraceptive use?

Accepted Answer

Being more than 30 years old

Answer

Heart disease

Answer

Epileptic patient

Answer

Migraine

Question 10

Oral contraceptive pills act mainly by?

Accepted Answer

Inhibition of ovulation

Answer

Production of cervical mucus hostile to sperm penetration

Answer

Making endometrium unsuitable for implantation

Answer

Enhancing uterine contraction to dislodge the fertilized ovum

Contraception and Family Planning — MCQs

Contraception and Family Planning — MCQs

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