Neurotology — MCQs

Neurotology Indian Medical PG Practice Questions and MCQs

Question 411: Which of the following is a common presenting symptom of vestibular schwannoma?

A. Conductive hearing loss
B. Unilateral tinnitus (Correct Answer)
C. Facial pain
D. Nasal obstruction

Explanation: ***Unilateral tinnitus*** - **Unilateral tinnitus** is one of the most common presenting symptoms of vestibular schwannoma, occurring in 60-70% of cases - Results from **compression or irritation of the vestibulocochlear nerve (CN VIII)** - Often accompanies or precedes **unilateral sensorineural hearing loss** (the most common presenting symptom at 90-95%) - Typically described as a **high-pitched ringing or buzzing** in the affected ear *Conductive hearing loss* - Vestibular schwannoma causes **sensorineural hearing loss**, not conductive hearing loss - The tumor arises from Schwann cells of the **vestibular portion of CN VIII** and affects the auditory nerve directly - **Conductive hearing loss** results from middle or outer ear pathology (otosclerosis, otitis media, cerumen impaction) *Facial pain* - **Facial pain** suggests **trigeminal nerve (CN V)** involvement, as in trigeminal neuralgia - While large vestibular schwannomas can eventually compress CN V, causing **facial numbness**, this is a late finding - **Facial pain** is not a common presenting symptom of vestibular schwannoma *Nasal obstruction* - **Nasal obstruction** relates to nasal or sinus pathology (rhinitis, polyps, deviated septum) - Has no anatomical connection to vestibular schwannoma, which arises in the **cerebellopontine angle** or **internal auditory canal**

Question 412: Hitselberger's sign is seen in?

A. Glomus Tumour
B. Nasal angiofibroma
C. Acute suppurative otitis media
D. Acoustic neuroma (Correct Answer)

Explanation: ***Acoustic neuroma*** - Hitselberger's sign is an area of **hypoesthesia** or **anesthesia** in the **posterosuperior portion of the external auditory canal**. - Acoustic neuromas (vestibular schwannomas) arise from the **vestibular portion of CN VIII** in the internal auditory canal. - This sign results from involvement of the **sensory fibers of the nervus intermedius** (sensory branch associated with the facial nerve) due to close anatomical proximity in the cerebellopontine angle. - This symptom, also known as the **"ear canal sign,"** is relatively specific for acoustic neuroma. *Glomus Tumour* - Glomus tumors are **highly vascular benign tumors** of the **middle ear** that present with **pulsatile tinnitus** and conductive hearing loss. - While they can affect cranial nerves, Hitselberger's sign is not a characteristic presentation. *Nasal angiofibroma* - Nasal angiofibromas are **benign, highly vascular tumors** found in the **nasopharynx**, primarily affecting adolescent males. - They typically present with **epistaxis** and **nasal obstruction** and do not cause Hitselberger's sign. *Acute suppurative otitis media* - Acute suppurative otitis media is an **infection of the middle ear** causing earache, fever, and hearing loss. - It does not involve the cerebellopontine angle or sensory innervation of the external auditory canal in a way that would lead to Hitselberger's sign.

Question 413: Which of the following is the MOST characteristic symptom of Gradenigo syndrome?

A. Diplopia (Correct Answer)
B. Retro-orbital pain
C. Persistent ear discharge
D. Vertigo

Explanation: ***Diplopia*** - **Diplopia** (double vision) due to **abducens nerve (CN VI)** palsy is the **most characteristic** symptom of **Gradenigo syndrome**. - Gradenigo syndrome (apical petrositis) presents with a **classic triad**: otorrhea, retro-orbital pain, and **abducens nerve palsy causing diplopia**. - The abducens nerve is affected as it traverses the **Dorello's canal** adjacent to the inflamed petrous apex. - **Diplopia is the defining neurological sign** that distinguishes Gradenigo syndrome from simple otitis media with mastoiditis. *Retro-orbital pain* - **Retro-orbital pain** is the second component of the classic triad, caused by irritation of the **trigeminal nerve (CN V)**, specifically the ophthalmic division. - While present in Gradenigo syndrome, it is **less specific** than diplopia, as retro-orbital pain can occur in many other conditions (orbital cellulitis, cavernous sinus thrombosis, cluster headache). - Pain is typically **unilateral** and severe. *Persistent ear discharge* - **Persistent ear discharge** (otorrhea) represents the underlying **otitis media** and **mastoiditis** that leads to Gradenigo syndrome. - It is the **first component of the triad** but is not specific to Gradenigo syndrome itself—otorrhea occurs in many cases of chronic otitis media without petrous apex involvement. - Gradenigo syndrome specifically describes the **neurological complications** from infection spreading to the **petrous apex**. *Vertigo* - **Vertigo** is **not part of the classic Gradenigo triad** and is not a characteristic symptom. - While vertigo can occur with inner ear involvement in complicated otitis media, it is inconsistent and non-specific for Gradenigo syndrome. - The hallmark features remain the triad of otorrhea, CN VI palsy (diplopia), and CN V irritation (retro-orbital pain).

Question 414: Which of the following can cause unilateral sensorineural hearing loss?

A. Coronavirus
B. Pertussis
C. Rotavirus
D. Acoustic neuroma (Correct Answer)

Explanation: ***Acoustic neuroma*** - An **acoustic neuroma** (vestibular schwannoma) is a benign tumor that grows on the **vestibulocochlear nerve** (cranial nerve VIII), which can compress the nerve and cause progressive unilateral sensorineural hearing loss. - Other associated symptoms often include **tinnitus** and **balance disturbances** (vertigo or unsteadiness). *Coronavirus* - While some reports suggest a rare association between **COVID-19** and sudden sensorineural hearing loss due to viral inflammation or vascular compromise, it is not a common or definitive cause of progressive unilateral hearing loss. - Hearing loss directly due to coronavirus infection is typically acute and bilateral, rather than chronic and unilateral. *Pertussis* - **Pertussis** (whooping cough) is a bacterial respiratory infection that does not typically cause sensorineural hearing loss. - Complications are primarily pulmonary, neurological (e.g., seizures due to hypoxia), or nutritional, not otological. *Rotavirus* - **Rotavirus** causes severe gastroenteritis, particularly in infants and young children. - There is no established link between rotavirus infection and sensorineural hearing loss.

Question 415: Which of the following statements about Glomus jugulare tumors is correct?

A. Arises from non-chromaffin cells. (Correct Answer)
B. Metastasize to lymph nodes.
C. None of the options.
D. More common in males than in females.

Explanation: ***Arises from non-chromaffin cells.*** - Glomus jugulare tumors are paragangliomas, which originate from **neuroectodermal cells** of the paraganglia system. - These cells are **non-chromaffin**, meaning they do not stain with chromium salts, unlike chromaffin cells found in the adrenal medulla. - This is a key distinguishing feature of glomus tumors. *Incorrect: More common in males than in females.* - This is **incorrect** - glomus jugulare tumors show a **strong female predominance** with a female-to-male ratio of approximately **4-6:1**. - This female predilection is a well-established epidemiological characteristic of these tumors. *Incorrect: Metastasize to lymph nodes.* - Glomus jugulare tumors are generally considered **benign** but locally aggressive, with a very **low metastatic potential** (~5%). - When metastasis does occur (rare), it typically involves distant sites like bone, lung, or liver, rather than regional lymph nodes. - Lymph node metastasis is not a characteristic feature. *Incorrect: None of the options.* - This option is incorrect because the statement "Arises from non-chromaffin cells" is a factually correct characteristic of glomus jugulare tumors. - Glomus tumors are derived from glomus cells, which are part of the non-chromaffin paraganglia system.

Question 416: Which of the following is the earliest symptom of acoustic neuroma?

A. Tinnitus
B. Facial weakness
C. Deafness (Correct Answer)
D. Vertigo

Explanation: ***Deafness*** - **Unilateral progressive sensorineural hearing loss** is the earliest and most common presenting symptom, occurring in **90-95% of patients** as the initial manifestation of acoustic neuroma. - This occurs due to compression and dysfunction of the **cochlear portion of the vestibulocochlear nerve (CN VIII)** as the tumor grows from the internal auditory canal. - The hearing loss is typically **gradual and progressive**, often beginning in the high-frequency range before affecting speech frequencies. *Tinnitus* - **Tinnitus** (ringing in the ear) is very common and often accompanies the early hearing loss, but it is rarely the sole presenting symptom. - It occurs in approximately 60-70% of patients, usually **concurrent with or following** the onset of hearing loss. - When present alone, it is caused by irritation of the **auditory nerve fibers** before significant compression. *Vertigo* - **True vertigo** (spinning sensation) is relatively uncommon as an initial symptom, occurring in only 10-20% of patients at presentation. - Most patients experience **mild imbalance or disequilibrium** rather than severe vertigo due to slow tumor growth allowing vestibular compensation. - Results from involvement of the **vestibular portion of CN VIII**. *Facial weakness* - **Facial weakness** is a **late symptom**, occurring when the tumor has grown large enough (typically >2-3 cm) to compress the **facial nerve (CN VII)** in the cerebellopontine angle. - The facial nerve is anatomically separate and less susceptible to early compression compared to the vestibulocochlear nerve.

Question 417: Findings of BERA in vestibular schwannoma are:

A. Increased I-V interpeak latency (Correct Answer)
B. Absent wave V
C. Normal interpeak latency I-III and I-V
D. Normal latency in waves I-V

Explanation: ***Increased I-V interpeak latency*** - A **vestibular schwannoma** (acoustic neuroma) compresses the auditory nerve, leading to delayed neural conduction through the brainstem auditory pathway. - This delay is reflected as a **prolonged I-V interpeak latency** (normally <4.4 ms), which is the most sensitive and characteristic BERA finding for retrocochlear pathology. - The **I-V interval** measures the time from the cochlear nerve (wave I) to the inferior colliculus (wave V), and prolongation indicates a lesion along this pathway. *Normal interpeak latency I-III and I-V* - This finding would suggest **normal conduction** times through the auditory pathway. - In a vestibular schwannoma, the interpeak latencies, particularly the **I-V interval**, are typically prolonged (>4.4 ms) due to the slow conduction caused by the tumor. *Absent wave V* - While wave V can be absent or poorly formed in severe cases of hearing loss or large tumors, it is **not the most sensitive early finding**. - **Increased I-V interpeak latency** is a more sensitive indicator of retrocochlear pathology, even before complete loss or absence of wave V occurs. *Normal latency in waves I-V* - Normal interpeak latencies would indicate a **healthy auditory nerve** and brainstem function. - This would effectively rule out a **vestibular schwannoma**, which characteristically interferes with neural transmission, causing prolongation of the I-V interpeak interval.

Practice by Chapter

Vestibular System Anatomy and Physiology

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Vestibular Testing

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Benign Paroxysmal Positional Vertigo

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Ménière's Disease

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Vestibular Neuritis

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Labyrinthitis

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Acoustic Neuroma

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Other Cerebellopontine Angle Tumors

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Facial Nerve Disorders

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Skull Base Surgery

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Cochlear Implantation

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Vestibular Schwannoma Management

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