Oral Cavity Cancer — MCQs
N3a TNM staging of head and neck tumors (AJCC 8th edition) shows:
Which of the following is the most significant premalignant condition of the oral cavity?
Which of the following is not a premalignant condition for oral cancer?
Carcinoma tongue less than 2 cm is treated by -
A patient presents with a cheek cancer of 2.5 cm size, which is close to and involves the alveolus, and is associated with a single mobile cervical lymph node of 6 cm size. What is the TNM staging?
Treatment of resectable T4N0M0 stage of head and neck carcinoma is?
True about tongue cancer:
Which cancers can cause referred otalgia (referred pain in the ear)? Select the most comprehensive answer.
Tongue fixation in a patient with carcinoma tongue is staged as
Which of the following is not a cause of oropharyngeal carcinoma?
Oral Cavity Cancer Indian Medical PG Practice Questions and MCQs
Question 1: N3a TNM staging of head and neck tumors (AJCC 8th edition) shows:
- A. Metastasis in a lymph node >6 cm (Correct Answer)
- B. Metastasis in lymph nodes >2 cm
- C. Metastasis in lymph nodes >5 cm
- D. None of the options
Explanation: ***Metastasis in a lymph node >6 cm*** - **N3a disease** in head and neck cancer staging (AJCC 8th edition) specifically refers to metastasis in a single lymph node larger than 6 cm in greatest dimension **without extranodal extension (ENE)**. - This applies to oral cavity, oropharynx (HPV-negative), hypopharynx, and larynx cancers. - **Note:** N3 staging also includes **N3b** (metastasis in any node with clinically overt ENE), but this question specifically asks about N3a criteria. *Metastasis in lymph nodes >2 cm* - Lymph nodes in the 2-3 cm range typically fall within **N1 or N2a categories**, depending on laterality and number of involved nodes. - **N3a disease** requires a single lymph node to exceed 6 cm in greatest dimension without ENE. *Metastasis in lymph nodes >5 cm* - A lymph node between 3-6 cm is usually classified as **N2 disease** (N2a if single ipsilateral ≤6 cm, N2b if multiple ipsilateral ≤6 cm, N2c if bilateral or contralateral ≤6 cm). - To be classified as **N3a**, the lymph node must be **>6 cm** without extranodal extension. *None of the options* - This option is incorrect because the first option accurately describes the size criterion for **N3a TNM staging** in head and neck tumors according to AJCC 8th edition guidelines. - While N3 staging has two subcategories (N3a and N3b), the size criterion of >6 cm correctly defines N3a disease.
Question 2: Which of the following is the most significant premalignant condition of the oral cavity?
- A. Fordyce spots
- B. Median rhomboid glossitis
- C. Erythema multiforme
- D. Erythroplakia (Correct Answer)
Explanation: **Erythroplakia** - Erythroplakia is characterized by a **red patch** on the mucous membrane that cannot be attributed to any other pathology. - It has a significantly higher rate of **malignant transformation** (up to 50%) compared to other oral premalignant conditions. *Fordyce spots* - These are **ectopic sebaceous glands** appearing as small, painless, yellowish-white papules on the oral mucosa, particularly the buccal mucosa and lips. - Fordyce spots are **normal anatomical variations** and have no malignant potential. *Median rhomboid glossitis* - This is a **chronic fungal infection** (Candida albicans) of the tongue, presenting as a reddish, rhomboid-shaped area in the midline of the dorsal tongue. - It is a **benign inflammatory condition** and is not considered premalignant. *Erythema multiforme* - Erythema multiforme is an **acute, inflammatory mucocutaneous disorder** triggered by infections (e.g., herpes simplex virus) or drugs. - It typically presents with **target lesions** on the skin and erosions/ulcers in the oral cavity but is not associated with an increased risk of malignancy.
Question 3: Which of the following is not a premalignant condition for oral cancer?
- A. Leukoplakia
- B. Erythroplakia
- C. Systemic Sclerosis (Correct Answer)
- D. Oral submucous fibrosis
Explanation: ***Systemic Sclerosis*** - Systemic sclerosis is primarily an **autoimmune disease** affecting connective tissue and does not have a direct association with the development of oral cancer. - Although oral manifestations can occur, systemic sclerosis is **not classified** as a premalignant condition for oral malignancies. *Leukoplakia* - Leukoplakia is characterized by **white patches** in the oral cavity and is considered a potentially **premalignant** lesion [1]. - It has a known association with the development of **squamous cell carcinoma** in the oral region [1]. *Erythroplakia* - Erythroplakia presents as **red lesions** in the oral cavity and has a higher risk of **malignant transformation** compared to leukoplakia. - It is regarded as a significant **premalignant condition** for oral cancer. *Oral submucous fibrosis* - This condition involves **fibrosis** of the oral mucosa and is recognized as a **premalignant condition** due to its association with increased cancer risk. - It often develops in individuals with a history of **betel quid** or areca nut use, contributing to cancer risk in the oral cavity [2]. **References:** [1] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Problems From Alimentary System Disease, pp. 344-345. [2] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Lung, pp. 738-739.
Question 4: Carcinoma tongue less than 2 cm is treated by -
- A. Excision and Radiotherapy
- B. Excision (Correct Answer)
- C. Chemotherapy
- D. Radiotherapy
Explanation: ***Excision*** - **Early-stage oral tongue carcinoma** (T1, less than 2 cm) is primarily treated with **surgical excision** due to its high cure rates. - The goal is complete removal with **clear margins**, which is often curative for small lesions. *Excision and Radiotherapy* - While excision is appropriate, **adjuvant radiotherapy** is typically reserved for larger tumors, those with **positive margins**, **lymph node involvement**, or **perineural/vascular invasion**. - For very small tumors (<2 cm) with clear margins and no high-risk features, radiotherapy is often **overtreatment** and adds unnecessary side effects. *Chemotherapy* - **Chemotherapy** is generally used in more advanced stages of oral tongue carcinoma, either as neoadjuvant therapy, concurrent with radiotherapy, or for metastatic disease. - It is **not a primary treatment** for early-stage localized disease due to its systemic toxicity and limited role in local control compared to surgery. *Radiotherapy* - **Radiotherapy alone** can be used as a primary treatment for oral tongue carcinoma, especially in patients who are **unfit for surgery** or refuse surgery. - However, for small lesions, **surgery typically offers better local control** and avoids the long-term side effects of radiation, such as xerostomia and osteoradionecrosis.
Question 5: A patient presents with a cheek cancer of 2.5 cm size, which is close to and involves the alveolus, and is associated with a single mobile cervical lymph node of 6 cm size. What is the TNM staging?
- A. T3 N2
- B. T4 N2 (Correct Answer)
- C. T3 N3
- D. T4 N3
Explanation: ***T4 N2*** - The primary tumor involving the **alveolus (cortical bone invasion)** is classified as **T4a** regardless of size according to AJCC TNM staging for oral cavity cancers. - A single mobile ipsilateral cervical lymph node of **6 cm** is classified as **N2a** (single ipsilateral node, 3-6 cm in greatest dimension). - Therefore, the correct staging is **T4 N2**. *T3 N2* - **T3 classification is incorrect** as alveolar involvement (cortical bone invasion) automatically upgrades the tumor to T4a. - While N2 is correct for a single 6 cm node, the T-stage is underestimated. *T4 N3* - While **T4 is correct** due to alveolar bone involvement, **N3 is incorrect**. - **N3a requires lymph nodes >6 cm** (greater than 6 cm), not equal to 6 cm. - A single 6 cm node falls within the N2a category (3-6 cm range). *T3 N3* - **Both T3 and N3 are incorrect** for this presentation. - Alveolar involvement mandates T4 staging, and a 6 cm node is N2a, not N3.
Question 6: Treatment of resectable T4N0M0 stage of head and neck carcinoma is?
- A. Radiotherapy alone
- B. Surgery and Radiotherapy (Correct Answer)
- C. Chemoradiation
- D. Surgery alone
Explanation: ***Surgery and Radiotherapy*** - For **resectable T4N0M0 head and neck carcinoma**, the standard treatment is **surgical resection** of the primary tumor followed by **adjuvant radiotherapy**. - This approach achieves optimal **local control** for advanced primary tumors without nodal involvement. - **Adjuvant radiotherapy** is essential for T4 tumors due to high risk of microscopic residual disease and local recurrence. - Surgery allows for complete tumor removal with negative margins, while radiotherapy addresses subclinical disease. *Radiotherapy alone* - Radiotherapy alone is **insufficient as monotherapy** for T4 tumors due to the large tumor burden and extensive local invasion. - Single modality radiation cannot reliably achieve adequate tumor control for advanced primary lesions. - Generally reserved for early-stage disease or patients unfit for surgery. *Chemoradiation* - **Definitive chemoradiation** is an alternative for **unresectable T4 tumors** or when organ preservation is desired (e.g., laryngeal cancer). - For **resectable** T4N0M0 disease, surgery with adjuvant RT is preferred as it provides better local control and allows pathological staging. - Chemoradiation may be used postoperatively if high-risk features are found (positive margins, perineural invasion, extranodal extension). - In this **N0 case with resectable tumor**, upfront surgery is the preferred initial approach. *Surgery alone* - While surgical resection is crucial for T4 tumors, **surgery alone is inadequate** due to high risk of locoregional recurrence. - T4 classification indicates extensive local invasion, necessitating **adjuvant radiotherapy** to eradicate microscopic disease. - Combined modality treatment (surgery + RT) significantly improves local control and survival compared to surgery alone.
Question 7: True about tongue cancer:
- A. Slurring of speech is a common complaint
- B. MC site is on Lateral margin (Correct Answer)
- C. Cervical lymph node metastasis is universally present
- D. Most common type is adenocarcinoma
Explanation: ***MC site is on Lateral margin*** - The **lateral border** of the tongue is the most common site for squamous cell carcinoma (SCC) of the tongue due to chronic irritation and exposure to carcinogens. - This anatomical location makes it susceptible to tumor development due to constant friction and potential for trauma. *Slurring of speech is a common complaint* - While speech can be affected by advanced tongue cancer, **dysarthria** (slurring of speech) is not typically an early or primary complaint. - Early symptoms often include a **painless lesion**, ulcer, or lump on the tongue. *Cervical lymph node metastasis is universally present* - While **cervical lymph node metastasis** is common in tongue cancer, its presence is not universal at diagnosis. - The incidence of metastasis varies depending on tumor size, depth of invasion, and location, ranging from 30% to 50% in early stages. *Most common type is adenocarcinoma* - The vast majority of tongue cancers, over 90%, are **squamous cell carcinomas (SCCs)**, arising from the epithelial cells. - **Adenocarcinoma** is a rare type of tongue cancer, originating from glandular tissue, and is not the most common histological type.
Question 8: Which cancers can cause referred otalgia (referred pain in the ear)? Select the most comprehensive answer.
- A. Cancer of the pharynx
- B. Cancer of the oral cavity
- C. Cancer of the pharynx, oral cavity, and larynx (Correct Answer)
- D. Cancer of the larynx
Explanation: ***Cancer of the pharynx, oral cavity, and larynx*** - Cancers in these locations can cause **referred otalgia** due to shared innervation of the ear by cranial nerves that also supply these areas. - Specifically, the **glossopharyngeal nerve (IX)**, **vagus nerve (X)**, and **trigeminal nerve (V3)** are involved in both sensation from these head and neck regions and the ear. *Cancer of the pharynx* - While pharyngeal cancer can cause **referred otalgia** through cranial nerves IX and X, it is not the most comprehensive answer as other sites are also involved. - This option exclusively mentions the pharynx, missing other important anatomical locations that can also refer pain to the ear. *Cancer of the oral cavity* - Cancer here can cause **referred otalgia**, primarily through the **trigeminal nerve (V3)**, which innervates parts of the oral cavity and the ear. - However, similar to pharyngeal cancer, this option is not comprehensive as it omits other regions related to referred ear pain. *Cancer of the larynx* - Laryngeal cancer can cause **referred otalgia** via the **vagus nerve (X)**, specifically its superior laryngeal branch. - This option is also incomplete as it does not include cancers of the pharynx or oral cavity, which are equally important causes of referred ear pain.
Question 9: Tongue fixation in a patient with carcinoma tongue is staged as
- A. T1
- B. T2
- C. T3
- D. T4 (Correct Answer)
Explanation: ***T4*** - **Tongue fixation** in carcinoma of the tongue indicates advanced local disease classified as **T4a stage** according to AJCC TNM staging. - This finding suggests invasion of **extrinsic tongue muscles**, which causes loss of tongue mobility and represents moderately advanced local disease. - T4a tumors invade through cortical bone, involve the inferior alveolar nerve, floor of mouth, or skin of face, or in the case of tongue, involve deep extrinsic muscles causing fixation. *T1* - **T1 tumors** are small lesions measuring **≤2 cm** in greatest dimension with **depth of invasion (DOI) ≤5 mm**. - They are superficial without invasion of deep structures or causing any functional impairment like tongue fixation. *T2* - **T2 tumors** measure **≤2 cm with DOI >5 mm and ≤10 mm**, OR **>2 cm but ≤4 cm with DOI ≤10 mm**. - While larger than T1, they do not involve deep extrinsic muscles or cause tongue fixation. *T3* - **T3 tumors** are defined as tumors **>4 cm** OR **any tumor with DOI >10 mm**. - Although T3 indicates larger tumor size and deeper invasion, **tongue fixation** specifically indicates T4a stage due to involvement of extrinsic tongue musculature.
Question 10: Which of the following is not a cause of oropharyngeal carcinoma?
- A. Occupational exposure to hydrochloric acid (Correct Answer)
- B. Smoking
- C. Human Papilloma Virus infection
- D. Occupational exposure to isopropyl oil
Explanation: **Explanation:** The primary risk factors for oropharyngeal carcinoma (OPC) are lifestyle-related and viral, rather than chemical or industrial. **1. Why Option A is the Correct Answer:** Occupational exposure to **hydrochloric acid (HCl)** is primarily associated with dental erosion and irritation of the upper respiratory tract, but it is **not** a recognized carcinogen for the oropharynx. In contrast, exposure to strong inorganic acid mists (like sulfuric acid) is linked specifically to **laryngeal cancer**, not oropharyngeal cancer. **2. Analysis of Other Options:** * **Smoking (Option B):** Tobacco use is a classic risk factor. Carcinogens like nitrosamines and polycyclic aromatic hydrocarbons cause field cancerization, leading to squamous cell carcinoma (SCC) of the entire aerodigestive tract. * **Human Papilloma Virus (Option C):** HPV (specifically **Type 16**) is now the leading cause of oropharyngeal cancer globally, especially involving the palatine tonsils and base of tongue. HPV-positive tumors have a better prognosis than tobacco-related ones. * **Isopropyl Oil (Option D):** Occupational exposure to the manufacture of isopropyl alcohol (specifically the "strong acid process" involving isopropyl oil) is a documented risk factor for cancers of the **paranasal sinuses and the oropharynx**. **Clinical Pearls for NEET-PG:** * **Most Common Site:** The **palatine tonsil** is the most common site for oropharyngeal SCC. * **HPV Marker:** **p16** immunohistochemistry is used as a surrogate marker for HPV-associated oropharyngeal cancer. * **Plummer-Vinson Syndrome:** Associated with post-cricoid (hypopharyngeal) carcinoma, not primarily oropharyngeal. * **Diet:** Deficiencies in Vitamin A and C are also implicated in the development of oral and pharyngeal malignancies.
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