Enzyme-Linked Receptors Practice Questions

Question 1

Match the following drugs with the targets of their actions:

Drugs:
A. Trastuzumab
B. Infliximab  
C. Sirolimus
D. Imatinib

Targets:
1. BCR-ABL tyrosine kinase
2. mTOR
3. TNF alpha
4. HER2/neu

Accepted Answer

A-4, B-3, C-2, D-1

Answer

A-2, B-3, C-1, D-4

Answer

A-3, B-4, C-2, D-1

Answer

A-4, B-3, C-1, D-2

Question 2

Which hormone acts on JAK-STAT kinase receptor?

Accepted Answer

GH

Answer

TSH

Answer

Thyroxine

Answer

FSH

Question 3

Which of the following is true?

1. BRCA1 is an oncogene
2. HER2neu is amplified only in a fraction of breast cancer
3. EGFR (+) is seen in non-small cell lung cancer
4. N-MYC is a tumor suppressor gene

Accepted Answer

2,3

Answer

1,3

Answer

1,2

Answer

All of the options

Question 4

What type of receptor is the insulin receptor?

Accepted Answer

Tyrosine kinase

Answer

Guanylyl cyclase

Answer

Adenylyl cyclase

Answer

IP3-DAG

Question 5

Which of the following statements best describes the mechanism of action of insulin on target cells?

Accepted Answer

Insulin binds to a transmembrane receptor on the outer surface of the plasma membrane, activating the tyrosine kinase in the cytosolic domain of the receptor.

Answer

Insulin binds to a receptor on the outer surface of the plasma membrane, activating adenylate cyclase through the Gs protein.

Answer

Insulin binds to a cytoplasmic receptor and is transferred as a hormone receptor complex to the nucleus to modulate gene expression.

Answer

Insulin enters the cell and causes the release of calcium ions from intracellular stores.

Question 6

Agent that acts through tyrosine kinase receptor is

Accepted Answer

Insulin

Answer

MSH

Answer

TSH

Answer

TRH

Question 7

In response to changes in Ca2+ concentration, which of the following Ca2+ binding proteins can modify the activity of many enzymes & proteins?

Accepted Answer

Calmodulin

Answer

Collagen

Answer

Kinesin

Answer

Elastin

Question 8

Which enzyme is responsible for the activation of Interleukin-1 (IL-1)?

Accepted Answer

Caspase 1

Answer

Caspase 3

Answer

Caspase 8

Answer

Caspase 5

Question 9

Which amino acid can be utilized in both gluconeogenesis and ketogenesis?

Accepted Answer

Tyrosine

Answer

Leucine

Answer

Valine

Answer

Arginine

Question 10

Which of the following binds to Tyrosine Kinase receptor?

Accepted Answer

Insulin

Answer

Glucagon

Answer

Prolactin

Answer

Growth Hormone

Enzyme-Linked Receptors — MCQs

Enzyme-Linked Receptors — MCQs

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