Transcription Factors and Gene Regulation Practice Questions

Question 1

miRNA binds to which part of the mRNA to inhibit translation?

Accepted Answer

3'UTR

Answer

Gene promoter

Answer

Gene body

Answer

5'UTR

Question 2

Steroid hormone receptors have attachment site for all except:

Accepted Answer

Transcription activators

Answer

Hormone responsive element

Answer

Steroid hormone

Answer

Transcription repressors

Question 3

Which of the following statements regarding Huntington’s chorea is true?

Accepted Answer

It is a trinucleotide repeat expansion type of disorder

Answer

There is a loss of function type of mutation.

Answer

It is an autosomal recessive disorder.

Answer

Increased number of CAA repeats.

Question 4

Identify the gene commonly involved in the condition shown in the image?

Accepted Answer

BRAF V600E

Answer

RAS

Answer

RET

Answer

P53

Question 5

Which type of mutation can act as a suppressor to restore the wild-type phenotype in organisms carrying a mutant gene?

Accepted Answer

Mutation of tRNA

Answer

Frameshift mutation of coding gene

Answer

Deletion of mutant gene

Answer

Addition of another normal gene

Question 6

Which of the following is an X-linked dominant disorder?

Accepted Answer

Vitamin D resistant rickets

Answer

Red green color blindness

Answer

Achondroplasia

Answer

Familial hypercholesterolemia

Question 7

Which one of the following is an autosomal dominant disorder?

Accepted Answer

Hereditary spherocytosis

Answer

Cystic fibrosis

Answer

Sickle cell anemia

Answer

G-6PD deficiency

Question 8

Which one of the following statements about chromatin is not true?

Accepted Answer

H2A-H2B bind to both the entry and exit ends of DNA in nucleosomes

Answer

DNA winds approximately 1.75 times around the nucleosomes

Answer

Covalent modification of histones influence chromatin compaction

Answer

Non-histone proteins are part of mitotic chromosomes

Question 9

Assertion: DNA methylation leads to gene silencing. Reason: Methylation prevents binding of transcription factors to promoter regions.

Accepted Answer

Both assertion and reason are true and reason is the correct explanation.

Answer

Assertion is true but reason is false.

Answer

Both assertion and reason are true but reason is not the correct explanation.

Answer

Both assertion and reason are false.

Question 10

Phenotypic expression of a gene depending on the parent of origin is referred to as:

Accepted Answer

Genomic imprinting (parent-of-origin gene expression)

Answer

Mosaic genetic variation

Answer

Nonpenetrance of genotype

Answer

Genetic anticipation

Transcription Factors and Gene Regulation — MCQs

Transcription Factors and Gene Regulation — MCQs

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