Hemoglobin Variants and Hemoglobinopathies — MCQs

A child presents with recurrent chest infections and abdominal pain. There is a history of 1 blood transfusion in the past. On examination, he had icterus and mild splenomegaly. Electrophoresis shows increased HbA2, HbF, and S spike. What is the likely diagnosis?

Which of the following statements is MOST accurate regarding cyanosis in methemoglobinemia?

In which type of hemoglobin are zeta 2 and gamma 2 chains present?

A 25-year-old lady presented with anemia, jaundice, and recurrent joint pains. All of the following are true except:

A patient with cyanosis and methemoglobinemia is treated with methylene blue. What is the mechanism of action of this drug?

Diagnosis of beta thalassemia is established by what?

A 45-year-old male presents with fatigue, pale skin, and jaundice. Labs reveal hemolysis and a positive direct Coombs test. What is the most likely diagnosis?

Which porphyrin forms the organic component of heme?

Why is blood stored in citrate-phosphate-dextrose considered more beneficial for hypoxic patients compared to blood stored in acidic-citrate-dextrose?

34 week primigravida punjabi khatri comes with history of consanguineous marriage, with history of repeated blood transfusion to her sibling since 8 months of age. The first diagnostic test is -