Hemoglobin Structure and Function Practice Questions

Question 1

Which factor predominantly influences the rightward shift of the oxygen dissociation curve?

Accepted Answer

2,3-Bisphosphoglycerate (2,3-BPG)

Answer

pH (Bohr effect)

Answer

Temperature increase

Answer

Carbon monoxide levels

Question 2

Which of the following statements about hemoglobin is true?

Accepted Answer

Hemoglobin consists of two alpha and two beta subunits, each capable of binding one O2 molecule.

Answer

Each hemoglobin molecule can bind up to six O2 molecules.

Answer

Each hemoglobin subunit contains two heme groups, which bind oxygen.

Answer

Each hemoglobin molecule is made of 6 polypeptide chains.

Question 3

What is the primary physiological effect of increased 2,3-DPG on hemoglobin?

Accepted Answer

Decreased affinity of hemoglobin to oxygen

Answer

Increased affinity of hemoglobin to oxygen

Answer

Left shift of oxygen-hemoglobin dissociation curve

Answer

Right shift of oxygen-hemoglobin dissociation curve

Question 4

Which local anaesthetic is known to cause methemoglobinemia?

Accepted Answer

Prilocaine

Answer

Procaine

Answer

Ropivacaine

Answer

Etidocaine

Question 5

All true about interaction of SpO2 reading and methemoglobinemia, except:

Accepted Answer

Does not get affected in Methemoglobinaemia

Answer

Increase in MetHb produces an overestimation when true SpO2 <85%

Answer

MetHb absorbs red and infrared wavelength of light in a 1:1 ratio corresponding

Answer

Increase in MetHb produces an underestimation when true SpO2 >85%

Question 6

Haemoglobin, unlike myoglobin, demonstrates a unique characteristic in its oxygen binding.

Accepted Answer

Co-operative effect of combined O2

Answer

Parabolic curve of oxygen association

Answer

Co-operative index of 81

Answer

Hill's coefficient of 1

Question 7

The daily production of hydrogen ions from CO2 is primarily buffered by which of the following?

Accepted Answer

Red blood cell hemoglobin

Answer

Red blood cell bicarbonate

Answer

Extracellular bicarbonate

Answer

Plasma proteins

Question 8

In which type of hemoglobin are zeta 2 and gamma 2 chains present?

Accepted Answer

Portland

Answer

Gower I

Answer

Gower II

Answer

Fetal hemoglobin

Question 9

Why is blood stored in citrate-phosphate-dextrose considered more beneficial for hypoxic patients compared to blood stored in acidic-citrate-dextrose?

Accepted Answer

The fall in 2,3-DPG is less.

Answer

It has a higher pH level than acidic-citrate-dextrose.

Answer

It is more effective in oxygen delivery.

Answer

It has a longer shelf life than acidic-citrate-dextrose.

Question 10

Which of the following statements about sickle cell anemia is false?

Accepted Answer

Ringed sideroblasts are associated with sickle cell anemia.

Answer

Sickle cells are present in sickle cell anemia.

Answer

Target cells are commonly seen in sickle cell anemia.

Answer

Howell Jolly bodies can be found in sickle cell anemia.

Hemoglobin Structure and Function — MCQs

Hemoglobin Structure and Function — MCQs

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