Phase I Reactions: Cytochrome P450 System — MCQs

The cytochrome involved in monooxygenase-mediated detoxification of drugs is:

Which drug should not be given with ketoconazole?

In the metabolism of xenobiotics, which of the following reactions does not occur in phase one?

Match the following drugs in Column A with their contraindications in Column B. | Column A | Column B | | :-- | :-- | | 1. Morphine | 1. QT prolongation | | 2. Amiodarone | 2. Thromboembolism | | 3. Vigabatrin | 3. Pregnancy | | 4. Estrogen preparations | 4. Head injury |

Which of the following cytochromes is involved in monooxygenase mediated detoxification of drugs?

A patient is on warfarin therapy. All of the following drugs increase the risk of bleeding with warfarin except?

Which of the following drugs is metabolized by CYP2D6?

Which of the following combinations can result in severe toxicity due to inhibition of cytochrome P450 enzymes?

Centrilobular necrosis of the liver may be seen with?

Decidual reaction is due to which hormone?