Gluconeogenesis: Reactions and Regulation Practice Questions

Question 1

Which pathway is primarily affected in glucose-6-phosphate dehydrogenase deficiency?

Accepted Answer

Pentose phosphate pathway

Answer

Gluconeogenesis

Answer

Glycolysis

Answer

Beta-oxidation

Question 2

Which of the following statements correctly describes the effect of insulin and glucagon on gluconeogenesis?

Accepted Answer

Glucagon decreases fructose 2,6-bisphosphate levels, stimulating gluconeogenesis.

Answer

Insulin increases the levels of fructose 2,6-bisphosphate, which inhibits gluconeogenesis.

Answer

Insulin acts through a kinase to promote glycolysis.

Answer

Fructose 2,6-bisphosphate is an activator of glycolysis.

Question 3

Which of the following is not a substrate for gluconeogenesis?

Accepted Answer

Leucine

Answer

Lactate

Answer

Propionate

Answer

Glycerol

Question 4

Enzyme activated by decrease in Insulin: glucagon ratio:

Accepted Answer

Glucose 6 phosphatase

Answer

PFK

Answer

Glucokinase

Answer

Hexokinase

Question 5

Which of the following is not a substrate for glucose formation?

Accepted Answer

Acetyl coenzyme A

Answer

Lactate

Answer

Glycerol

Answer

Alanine

Question 6

Which of the following is true about the synthesis of glucose from pyruvate by gluconeogenesis?

Accepted Answer

Requires the participation of biotin

Answer

Occurs exclusively in the cytosol.

Answer

Is inhibited by an elevated level of glucagon

Answer

Involves lactate as an intermediate

Question 7

Which amino acid can be utilized in both gluconeogenesis and ketogenesis?

Accepted Answer

Tyrosine

Answer

Leucine

Answer

Valine

Answer

Arginine

Question 8

Gluconeogenesis is inhibited by?

Accepted Answer

Insulin

Answer

Cholecystokinin

Answer

5-alpha reductase

Answer

Glucagon

Question 9

Which one of the following statements concerning gluconeogenesis is correct?

Accepted Answer

It is important in maintaining blood glucose during the normal overnight fast.

Answer

It occurs primarily in the liver.

Answer

It is stimulated by elevated levels of acetyl CoA.

Answer

It is primarily inhibited by insulin.

Question 10

When the insulin:glucagon ratio is decreased, which enzyme is active?

Accepted Answer

Glucose-6-phosphatase

Answer

Glucokinase

Answer

Phosphofructokinase

Answer

Hexokinase

Gluconeogenesis: Reactions and Regulation — MCQs

Gluconeogenesis: Reactions and Regulation — MCQs

Want unlimited practice?