Management of Diabetic Patients — MCQs

10 questions

What should be the minimum value of HbA1c to safely carry out a surgical procedure in an emergency setting?

What is normal range of glycosylated haemoglobin (HbA1c) for adequate glycaemic control in diabetic patient-

Mr. Murali has 126 mg/dl of fasting plasma glucose. His venous plasma glucose 2h after ingestion of 75g oral glucose load is 149 mg/dl. This patient comes under which stage of WHO diagnostic criteria of diabetes & intermediate hyperglycemia?

Which of the following is false regarding management of diabetes in pregnancy?

In a comatose patient with a blood glucose level of 750 mg/dL, which test is most important to perform in addition to serum potassium?

SAFE strategy is for:

In a patient presenting with diabetic ketoacidosis (DKA), what is the most appropriate immediate treatment?

A diabetic patient's fasting blood glucose level is found to be $160 \mathrm{mg} / \mathrm{dL}$. What will you advise the patient regarding non-pharmacological management?

SAFE strategy is recommended for-

Q10

Insulin of choice for the treatment of diabetic ketoacidosis is:

Management of Diabetic Patients Indian Medical PG Practice Questions and MCQs

Question 1: What should be the minimum value of HbA1c to safely carry out a surgical procedure in an emergency setting?

A. <7
B. <8
C. <10 (Correct Answer)
D. <8

Explanation: ***<10*** - In an **emergency setting**, the priority is to proceed rapidly with surgery; current guidelines suggest that an **HbA1c <10%** is acceptable to proceed without significant delay for optimization. - While lower HbA1c is ideal, delaying an emergency procedure to achieve an HbA1c below 10% is generally **not recommended**, as the benefits of urgent surgery outweigh the risks associated with this level of glycemic control [1]. *<7* - An HbA1c of **<7% is the general target** for optimal glycemic control in most diabetic patients, especially in an elective setting. - Achieving this level in an emergency would likely require **delaying surgery**, which is not feasible or safe when immediate intervention is needed. *<8* - An HbA1c of **<8%** represents good control for many individuals, particularly older adults or those with comorbidities. - While better than 10%, it is not the absolute minimum required to proceed with an **emergency surgery**, as timely intervention is paramount. *<8* - An HbA1c of **<8%** represents good control for many individuals, particularly older adults or those with comorbidities. - While better than 10%, it is not the absolute minimum required to proceed with an **emergency surgery**, as timely intervention is paramount.

Question 2: What is normal range of glycosylated haemoglobin (HbA1c) for adequate glycaemic control in diabetic patient-

A. 10 % to 12 %
B. 8 % to 10 %
C. 4 % to 6 % (Correct Answer)
D. 6% to 8 %

Explanation: ***4% to 6%*** - This range represents **excellent glycemic control** and is closest to the recommended target of **less than 7%** for adequate diabetes management [1]. - While it requires careful monitoring for **hypoglycemia risk**, it significantly reduces the risk of **microvascular** and **macrovascular complications** [1]. *10% to 12%* - This range indicates very **poor glycemic control** and significantly increases the risk of both acute and chronic diabetes complications. - An HbA1c in this range suggests that the patient's blood glucose levels have been consistently high over several months. *8% to 10%* - While better than 10-12%, an HbA1c in this range still indicates **suboptimal glycemic control** for most diabetic patients. - It suggests a need for adjustments in treatment, diet, or lifestyle to prevent long-term complications. *6% to 8%* - This range is **too broad** for adequate glycemic control, with the upper limit of 8% being acceptable only for **elderly patients** or those with **significant comorbidities** [1]. - For most diabetic patients seeking adequate control, this range exceeds the recommended target of **less than 7%** [1].

Question 3: Mr. Murali has 126 mg/dl of fasting plasma glucose. His venous plasma glucose 2h after ingestion of 75g oral glucose load is 149 mg/dl. This patient comes under which stage of WHO diagnostic criteria of diabetes & intermediate hyperglycemia?

A. Decreased glucose resistance
B. IFG - Impaired fasting glucose
C. Diagnosis of diabetes (Correct Answer)
D. Impaired glucose tolerance

Explanation: **Diagnosis of diabetes** - The **fasting plasma glucose (FPG)** of 126 mg/dL meets the WHO criterion for **diabetes**, which is FPG ≥ 126 mg/dL [1]. - Although the 2-hour post-glucose load (149 mg/dL) falls within the **impaired glucose tolerance (IGT)** range (140-199 mg/dL), the elevated fasting glucose alone is sufficient for a diabetes diagnosis according to WHO guidelines. *Decreased glucose resistance* - This term is not a standard diagnostic category recognized by the WHO for glucose metabolism disorders. - Glucose resistance is more commonly associated with conditions like **insulin resistance** rather than a specific diagnostic stage [1]. *IFG - Impaired fasting glucose* - **Impaired fasting glucose (IFG)** is defined by a fasting plasma glucose level between 100 mg/dL and 125 mg/dL. - Mr. Murali's fasting glucose of 126 mg/dL is higher than the upper limit for IFG [1]. *Impaired glucose tolerance* - **Impaired glucose tolerance (IGT)** is defined by a 2-hour post-glucose load plasma glucose level between 140 mg/dL and 199 mg/dL. - While Mr. Murali's 2-hour reading of 149 mg/dL falls within this range, the elevated fasting glucose level takes precedence for the overall diagnosis [1].

Question 4: Which of the following is false regarding management of diabetes in pregnancy?

A. In active labor, if RBS <70 mg/dL, D5 is started at 100-150 ml/hr till the RBS is >70 mg/dL
B. In a patient being planned for induction of labor, night dose of intermediate insulin is given as planned, and the morning dose is withheld
C. Elective C-section has no role in reducing incidence of brachial plexus injury (Correct Answer)
D. Capillary blood glucose monitoring levels are kept at fasting- 95 mg/dL; 1 hr postprandial- 140 mg/dL; 2 hrs postprandial- 120 mg/dL

Explanation: ***Elective C-section has no role in reducing incidence of brachial plexus injury*** - This statement is **false** because **elective C-section** can significantly reduce the incidence of **brachial plexus injury** (BPI), especially in cases of suspected fetal macrosomia. - While not universally recommended for all diabetic pregnancies, an elective C-section is considered when the estimated **fetal weight** is substantial or when there's a history of **shoulder dystocia** to prevent birth trauma. *In active labor, if RBS <70 mg/dL, D5 is started at 100-150 ml/hr till the RBS is >70 mg/dL* - This is a **correct** management strategy for **hypoglycemia in labor**. Maintaining stable blood glucose levels (above 70 mg/dL) is crucial to prevent adverse outcomes for both mother and fetus. - The administration of **D5 (dextrose 5% in water)** intravenous solution at a specific rate helps to quickly raise and maintain blood glucose levels. *In a patient being planned for induction of labor, night dose of intermediate insulin is given as planned, and the morning dose is withheld* - This is a common and generally **correct** practice for insulin management before **induction of labor**. The night dose of intermediate insulin helps maintain basal glucose levels overnight. - Withholding the morning dose prevents **hypoglycemia** during labor when food intake is restricted, and insulin sensitivity may increase. Glucose is then typically supplemented through IV fluids as needed. *Capillary blood glucose monitoring levels are kept at fasting- 95 mg/dL; 1 hr postprandial- 140 mg/dL; 2 hrs postprandial- 120 mg/dL* - These are the generally accepted and **correct** target blood glucose levels for **diabetes in pregnancy** (both pre-existing and gestational diabetes). - Achieving these targets is essential to minimize the risk of **fetal macrosomia**, **neonatal hypoglycemia**, and other adverse perinatal outcomes.

Question 5: In a comatose patient with a blood glucose level of 750 mg/dL, which test is most important to perform in addition to serum potassium?

A. Serum creatinine
B. Serum sodium
C. Serum ketones
D. Arterial blood gases (Correct Answer)

Explanation: ***Arterial blood gases*** - In a comatose patient with severe hyperglycemia (750 mg/dL), **arterial blood gases (ABGs)** are crucial to assess for **acidosis**, which could indicate **diabetic ketoacidosis (DKA)** or **hyperosmolar hyperglycemic state (HHS)** with lactic acidosis [1], [4]. - The **pH**, **bicarbonate (HCO3-)**, and **pCO2** levels from ABGs help determine the severity and type of metabolic derangement, guiding immediate treatment, especially for potential **cerebral edema** [3], [4]. *Serum creatinine* - While important for assessing **kidney function** in hyperosmolar states, it does not directly evaluate the immediate acid-base status that is critical for neurologic function in a comatose patient. - Renal insufficiency can exacerbate electrolyte imbalances and fluid overload but is secondary to the immediate need for acid-base assessment. *Serum sodium* - **Serum sodium** is important for calculating **effective serum osmolality**, which is elevated in both DKA and HHS, contributing to mental status changes [2]. - However, while important, it does not provide information about the **acid-base balance**, which is a more critical determinant of immediate neurologic stability and treatment in deep coma. *Serum ketones* - **Serum ketones** are essential for distinguishing between **DKA** (high ketones) and **HHS** (low or absent ketones) [4]. - While vital for diagnosis, ketones alone do not give the full picture of **acid-base status** (pH, bicarbonate) which is directly assessed by ABGs and more immediately actionable in managing a severely ill, comatose patient [1].

Question 6: SAFE strategy is for:

A. Onchocerciasis
B. Glaucoma
C. Diabetic retinopathy
D. Trachoma (Correct Answer)

Explanation: ***Trachoma*** - The **SAFE strategy** is a comprehensive public health approach designed to eliminate **trachoma**, a preventable cause of blindness. - SAFE stands for **Surgery** for trichiasis, **Antibiotics** to treat active infection, **Facial cleanliness** to reduce transmission, and **Environmental improvement** (especially access to water and sanitation) to prevent reinfection. *Onchocerciasia* - This condition, also known as **river blindness**, is primarily managed through mass drug administration of **ivermectin**. - While public health interventions are crucial for onchocerciasis, the specific SAFE acronym is not associated with its control program. *Glaucoma* - The management of glaucoma focuses on lowering **intraocular pressure** through medications, laser treatment, or surgery. - It is a chronic eye condition that does not involve infectious agents like trachoma, and the SAFE strategy is irrelevant. *Diabetic retinopathy* - This complication of diabetes is managed by controlling **blood sugar**, blood pressure, and lipids, along with specific ophthalmological treatments like laser photocoagulation or anti-VEGF injections. - It is a non-infectious, metabolic disease, making the SAFE strategy inapplicable.

Question 7: In a patient presenting with diabetic ketoacidosis (DKA), what is the most appropriate immediate treatment?

A. Administration of an oral hypoglycemic agent
B. Administration of bicarbonate
C. Administration of insulin (Correct Answer)
D. Close observation only

Explanation: ***Administration of insulin*** - **Insulin therapy** is critical in DKA to reverse the underlying metabolic abnormalities by stopping ketogenesis and facilitating glucose uptake into cells [1]. - It is typically administered intravenously at a continuous rate, after initial **fluid resuscitation**, to gradually lower blood glucose and resolve acidosis [1]. *Administration of an oral hypoglycemic agent* - **Oral hypoglycemic agents** are ineffective in DKA because these patients typically have an absolute or relative **insulin deficiency** and **profound insulin resistance** due to stress hormones [3]. - Moreover, they are not suitable for acutely ill patients who may have impaired gastrointestinal absorption. *Administration of bicarbonate* - **Bicarbonate administration** is generally not recommended in DKA unless the **pH is extremely low** (e.g., < 6.9 or 7.0) due to potential risks like paradoxical central nervous system acidosis and fluid overload. - The acidosis usually resolves with **insulin therapy** and **fluid resuscitation** as ketone body production ceases and they are metabolized [1]. *Close observation only* - **Diabetic ketoacidosis** is a medical emergency requiring urgent and aggressive intervention, not just observation [2]. - Delaying treatment can lead to severe complications, including **cerebral edema**, **coma**, and **death** [2].

Question 8: A diabetic patient's fasting blood glucose level is found to be $160 \mathrm{mg} / \mathrm{dL}$. What will you advise the patient regarding non-pharmacological management?

A. At least 25-35 g of dietary fibre
B. <30 % of the calories should come from fat (Correct Answer)
C. Dietary cholesterol <300 mg per day
D. <2.3 g sodium intake every day

Explanation: ***<30 % of the calories should come from fat*** - Reducing dietary fat intake to less than 30% of total calories is a crucial non-pharmacological strategy for diabetic patients to manage blood glucose levels and prevent cardiovascular complications [1]. - Excess dietary fat, especially saturated and trans fats, can contribute to insulin resistance and weight gain, both of which negatively impact glycemic control [1]. *At least 25-35 g of dietary fibre* - While adequate dietary fiber (typically 25-30g for adults, sometimes up to 35g for men) is beneficial for managing blood glucose, it is generally recommended as a baseline for healthy eating and not the primary or most impactful intervention to address a fasting glucose of 160 mg/dL [1]. - Fiber helps slow glucose absorption and can improve insulin sensitivity, but a specific "at least 25-35g" statement without further context on total caloric intake or other macronutrient distribution might not be the most targeted advice for this specific glucose level [1]. *Dietary cholesterol <300 mg per day* - Limiting dietary cholesterol to less than 300 mg per day is a general recommendation for cardiovascular health, which is particularly important for diabetic patients due to their increased risk of atherosclerosis [2]. - However, for directly addressing a fasting blood glucose of 160 mg/dL, focusing on overall fat intake and carbohydrate quality would have a more immediate impact on glucose control than dietary cholesterol alone. *<2.3 g sodium intake every day* - Restricting sodium intake to less than 2.3 g per day is recommended for managing hypertension and reducing cardiovascular risk, which is often comorbid with diabetes [2]. - While important for overall health in diabetic patients, this recommendation does not directly target blood glucose control and would not be the primary non-pharmacological advice for a fasting glucose of 160 mg/dL.

Question 9: SAFE strategy is recommended for-

A. Diabetic retinopathy
B. Trachoma (Correct Answer)
C. Glaucoma
D. Cataract

Explanation: ***Trachoma*** * The **SAFE strategy (Surgery, Antibiotics, Facial Cleanliness, Environmental improvement)** is the WHO-recommended public health approach for the elimination of **trachoma**, a chronic eye infection caused by *Chlamydia trachomatis*. * This comprehensive strategy addresses both active infection and its blinding sequelae, specifically **trichiasis** (in-turned eyelashes) through surgery. *Diabetic retinopathy* * Management of diabetic retinopathy primarily involves **blood sugar control, regular ophthalmologic exams, laser photocoagulation, and anti-VEGF injections**, not the SAFE strategy. * The focus is on preventing and treating retinal damage caused by **diabetes**, which is distinct from infectious causes. *Glaucoma* * Glaucoma is characterized by **optic nerve damage** and visual field loss, usually due to elevated intraocular pressure, and is managed with **medication, laser therapy, or surgery (e.g., trabeculectomy)**. * It is a **neurodegenerative condition**, not an infectious disease, so the SAFE strategy is not applicable. *Cataract* * Cataracts involve the **clouding of the natural lens** of the eye, leading to blurred vision, and are primarily treated through **surgical removal of the cloudy lens** and implantation of an artificial intraocular lens. * This condition is age-related or can be caused by trauma or disease, but it is **not an infection** for which the SAFE strategy would be relevant.

Question 10: Insulin of choice for the treatment of diabetic ketoacidosis is:

A. Insulin lispro
B. Insulin glargine
C. NPH insulin
D. Regular Insulin (Correct Answer)

Explanation: ***Regular Insulin*** - **Regular insulin** is the insulin of choice for treating **diabetic ketoacidosis (DKA)** because it can be administered intravenously. - Its **short onset of action** and predictable duration allow for rapid and precise titration in a critical care setting. *Insulin lispro* - **Insulin lispro** is a **rapid-acting insulin analog** typically used for mealtime coverage, which has a very quick onset and short duration. - While it acts quickly, its primary use is not for the continuous intravenous infusion required in DKA management. *Insulin glargine* - **Insulin glargine** is a **long-acting insulin analog** designed to provide basal insulin replacement. - It has a prolonged duration of action and a slow, sustained release profile, making it unsuitable for the rapid correction needed in DKA. *NPH insulin* - **NPH insulin** is an **intermediate-acting insulin** that has a delayed onset and peak effect. - Its insoluble nature and variable absorption make it inappropriate for the acute, immediate intravenous insulin therapy required in DKA.

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