UPSC-CMS 2025 — Anesthesiology

Q: Which of the following conditions are contraindications for noninvasive positive-pressure ventilation in patients with respiratory failure? I. Craniofacial abnormalities II. Significant burns III. Respiratory failure with PaCO_2 of 60 mm Hg IV. Cardiovascular instability Select the correct answer using the code given below :

I, II and IV. ***I, II and IV*** - **Craniofacial abnormalities** (I) can prevent a proper mask seal, leading to air leaks and ineffective ventilation. - **Significant burns** (II), especially on the face, can make mask application impossible due to pain, skin integrity issues, and infection risk. - **Cardiovascular instability** (IV), such as severe hypotension or active myocardial ischemia, can be worsened by the positive intrathoracic pressure applied by NPPV, which can decrease venous return and cardiac output. *I, III and IV* - While **craniofacial abnormalities** (I) and **cardiovascular instability** (IV) are contraindications, NPPV can be beneficial for **respiratory failure with a PaCO2 of 60 mm Hg** (III) as it helps reduce CO2 levels and avoids intubation. - Therefore, including III as a contraindication makes this option incorrect. *II, III and IV* - **Significant burns** (II) and **cardiovascular instability** (IV) are clear contraindications. However, **respiratory failure with a PaCO2 of 60 mm Hg** (III) is often an indication for NPPV, not a contraindication. - This option incorrectly identifies a key indication as a contraindication. *I, II and III* - **Craniofacial abnormalities** (I) and **significant burns** (II) are valid contraindications for NPPV. - However, **respiratory failure with a PaCO2 of 60 mm Hg** (III) is a common indication for NPPV, especially in conditions like COPD exacerbations, as it helps improve ventilation and reduce hypercapnia. [Practice more Anesthesiology PYQs on OnCourse]

Q: Peri-operative respiratory failure is an example of

Type III respiratory failure. ***Type III respiratory failure*** - This is often termed **peri-operative respiratory failure**, characterized by **atelectasis**, **reduced functional residual capacity**, and abnormal gas exchange post-surgery. - It results from the effects of anesthesia, surgery, and pain on respiratory mechanics, leading to **poor lung expansion** and hypoxemia. *Type II respiratory failure* - Characterized by **hypercapnia (high PCO2)** and **hypoxemia (low PO2)**, indicating inadequate alveolar ventilation. - Common causes include conditions like **COPD exacerbations** or **neuromuscular disorders** impacting the respiratory pump. *Type I respiratory failure* - Defined by **hypoxemia (low PO2)** with normal or low PCO2, indicating a primary problem with oxygenation. - Examples include **pulmonary edema** or **pneumonia**, where gas exchange is impaired at the alveolar-capillary membrane. *Type IV respiratory failure* - This categorization refers to **shock-related respiratory failure**, where inadequate oxygen delivery to respiratory muscles leads to their failure. - It is typically seen in states of **severe circulatory collapse**, such as septic or cardiogenic shock, and is not directly related to the peri-operative period in the way Type III is. [Practice more Anesthesiology PYQs on OnCourse]

Q: Which of the following are advantages of endotracheal intubation, in a child requiring pediatric advanced life support? I. Inspiratory time can be controlled II. Positive end-expiratory pressure can be provided III. Peak expiratory pressure can be controlled IV. Reduced risk of aspiration of gastric contents Select the correct answer using the code given below :

I, II and IV. ***I, II and IV*** - Endotracheal intubation allows for precise control of **inspiratory time**, optimizing ventilation for the child's respiratory mechanics. - It enables the application of **positive end-expiratory pressure (PEEP)**, which helps maintain alveolar patency and improves oxygenation. - An endotracheal tube provides a sealed airway, significantly **reducing the risk of aspiration** of gastric contents into the lungs. *II, III and IV* - While PEEP can be provided and aspiration risk is reduced, endotracheal intubation primarily controls **peak inspiratory pressure**, not peak expiratory pressure. - **Peak expiratory pressure** is usually determined by the patient's lung mechanics and the ventilator's exhalation valve settings, not directly controlled by the tube. *I, III and IV* - Endotracheal intubation allows control of inspiratory time and reduces aspiration risk, but it does not directly control **peak expiratory pressure**. - **Peak expiratory pressure** is largely a function of the patient's lung recoil and airway resistance during exhalation. *I, II and III* - Although inspiratory time can be controlled and PEEP can be provided, **peak expiratory pressure** is not a primary parameter controlled by endotracheal intubation. - The main benefits revolve around controlled ventilation and airway protection, not active control over **peak expiratory pressure**. [Practice more Anesthesiology PYQs on OnCourse]

Q: The commonly used muscle relaxant with quickest onset of action and spontaneous recovery is :

Suxamethonium. ***Suxamethonium*** - Suxamethonium (succinylcholine) is a **depolarizing neuromuscular blocker** with the most rapid onset of action (30-60 seconds) due to its unique mechanism. - Its short duration of action and **spontaneous recovery** are due to its rapid hydrolysis by **plasma pseudocholinesterase**, making it ideal for rapid sequence intubation. *Vecuronium* - Vecuronium is an **intermediate-duration non-depolarizing neuromuscular blocker** with an onset of action typically around 3-5 minutes, which is slower than suxamethonium. - It does not undergo spontaneous recovery as rapidly as suxamethonium and often requires administration of a **reversal agent**. *Rocuronium* - Rocuronium is a **non-depolarizing neuromuscular blocker** known for its relatively rapid onset of action (60-90 seconds) among non-depolarizing agents, but it is still slower than suxamethonium. - While it can be reversed quickly with sugammadex, its **spontaneous recovery** is much slower than suxamethonium. *Atracurium* - Atracurium is an **intermediate-duration non-depolarizing neuromuscular blocker** with an onset of action (3-5 minutes) that is slower than suxamethonium. - Its metabolism involves **Hofmann elimination** and ester hydrolysis, providing a degree of organ-independent elimination, but its recovery is not as rapid or spontaneous as suxamethonium. [Practice more Anesthesiology PYQs on OnCourse]

Q: Mallampati test is used for the assessment of :

Airway. ***Airway*** - The **Mallampati test** is a widely used bedside test to assess the **visibility of the soft palate, uvula, tonsillar pillars, and tongue** within the oral cavity. - This assessment helps in predicting the **ease of intubation** and the potential for a difficult airway during anesthesia. *Tongue size* - While the Mallampati test indirectly considers the relative size of the tongue by visualizing how much of the pharynx it obstructs, its primary purpose is not to quantify **tongue size** independently. - The test assesses the **overall oral cavity geometry** for airway management, not just a single anatomical dimension. *Ability to protrude jaw* - The ability to protrude the jaw, or **mandibular protrusion**, is a different airway assessment parameter used to evaluate potential difficulty with intubation. - It is often assessed with the **upper lip bite test** or other maneuvers, not the Mallampati classification. *Breath hold time* - **Breath-hold time** is a measure related to respiratory function and patient cooperation, and it has no direct relevance to the Mallampati test. - The Mallampati test is a **visual assessment** of oral pharyngeal structures at rest or with phonation, not a dynamic respiratory measurement. [Practice more Anesthesiology PYQs on OnCourse]

5 Previous Year Questions with Answers & Explanations

Questions

Which of the following conditions are contraindications for noninvasive positive-pressure ventilation in patients with respiratory failure? I. Craniofacial abnormalities II. Significant burns III. Respiratory failure with PaCO_2 of 60 mm Hg IV. Cardiovascular instability Select the correct answer using the code given below :

Peri-operative respiratory failure is an example of

Which of the following are advantages of endotracheal intubation, in a child requiring pediatric advanced life support? I. Inspiratory time can be controlled II. Positive end-expiratory pressure can be provided III. Peak expiratory pressure can be controlled IV. Reduced risk of aspiration of gastric contents Select the correct answer using the code given below :

The commonly used muscle relaxant with quickest onset of action and spontaneous recovery is :

Mallampati test is used for the assessment of :

UPSC-CMS 2025 - Anesthesiology UPSC-CMS Practice Questions and MCQs

Question 1: Which of the following conditions are contraindications for noninvasive positive-pressure ventilation in patients with respiratory failure? I. Craniofacial abnormalities II. Significant burns III. Respiratory failure with PaCO_2 of 60 mm Hg IV. Cardiovascular instability Select the correct answer using the code given below :

A. I, III and IV
B. II, III and IV
C. I, II and IV (Correct Answer)
D. I, II and III

Explanation: ***I, II and IV*** - **Craniofacial abnormalities** (I) can prevent a proper mask seal, leading to air leaks and ineffective ventilation. - **Significant burns** (II), especially on the face, can make mask application impossible due to pain, skin integrity issues, and infection risk. - **Cardiovascular instability** (IV), such as severe hypotension or active myocardial ischemia, can be worsened by the positive intrathoracic pressure applied by NPPV, which can decrease venous return and cardiac output. *I, III and IV* - While **craniofacial abnormalities** (I) and **cardiovascular instability** (IV) are contraindications, NPPV can be beneficial for **respiratory failure with a PaCO2 of 60 mm Hg** (III) as it helps reduce CO2 levels and avoids intubation. - Therefore, including III as a contraindication makes this option incorrect. *II, III and IV* - **Significant burns** (II) and **cardiovascular instability** (IV) are clear contraindications. However, **respiratory failure with a PaCO2 of 60 mm Hg** (III) is often an indication for NPPV, not a contraindication. - This option incorrectly identifies a key indication as a contraindication. *I, II and III* - **Craniofacial abnormalities** (I) and **significant burns** (II) are valid contraindications for NPPV. - However, **respiratory failure with a PaCO2 of 60 mm Hg** (III) is a common indication for NPPV, especially in conditions like COPD exacerbations, as it helps improve ventilation and reduce hypercapnia.

Question 2: Peri-operative respiratory failure is an example of

A. Type II respiratory failure
B. Type III respiratory failure (Correct Answer)
C. Type I respiratory failure
D. Type IV respiratory failure

Explanation: ***Type III respiratory failure*** - This is often termed **peri-operative respiratory failure**, characterized by **atelectasis**, **reduced functional residual capacity**, and abnormal gas exchange post-surgery. - It results from the effects of anesthesia, surgery, and pain on respiratory mechanics, leading to **poor lung expansion** and hypoxemia. *Type II respiratory failure* - Characterized by **hypercapnia (high PCO2)** and **hypoxemia (low PO2)**, indicating inadequate alveolar ventilation. - Common causes include conditions like **COPD exacerbations** or **neuromuscular disorders** impacting the respiratory pump. *Type I respiratory failure* - Defined by **hypoxemia (low PO2)** with normal or low PCO2, indicating a primary problem with oxygenation. - Examples include **pulmonary edema** or **pneumonia**, where gas exchange is impaired at the alveolar-capillary membrane. *Type IV respiratory failure* - This categorization refers to **shock-related respiratory failure**, where inadequate oxygen delivery to respiratory muscles leads to their failure. - It is typically seen in states of **severe circulatory collapse**, such as septic or cardiogenic shock, and is not directly related to the peri-operative period in the way Type III is.

Question 3: Which of the following are advantages of endotracheal intubation, in a child requiring pediatric advanced life support? I. Inspiratory time can be controlled II. Positive end-expiratory pressure can be provided III. Peak expiratory pressure can be controlled IV. Reduced risk of aspiration of gastric contents Select the correct answer using the code given below :

A. II, III and IV
B. I, II and IV (Correct Answer)
C. I, III and IV
D. I, II and III

Explanation: ***I, II and IV*** - Endotracheal intubation allows for precise control of **inspiratory time**, optimizing ventilation for the child's respiratory mechanics. - It enables the application of **positive end-expiratory pressure (PEEP)**, which helps maintain alveolar patency and improves oxygenation. - An endotracheal tube provides a sealed airway, significantly **reducing the risk of aspiration** of gastric contents into the lungs. *II, III and IV* - While PEEP can be provided and aspiration risk is reduced, endotracheal intubation primarily controls **peak inspiratory pressure**, not peak expiratory pressure. - **Peak expiratory pressure** is usually determined by the patient's lung mechanics and the ventilator's exhalation valve settings, not directly controlled by the tube. *I, III and IV* - Endotracheal intubation allows control of inspiratory time and reduces aspiration risk, but it does not directly control **peak expiratory pressure**. - **Peak expiratory pressure** is largely a function of the patient's lung recoil and airway resistance during exhalation. *I, II and III* - Although inspiratory time can be controlled and PEEP can be provided, **peak expiratory pressure** is not a primary parameter controlled by endotracheal intubation. - The main benefits revolve around controlled ventilation and airway protection, not active control over **peak expiratory pressure**.

Question 4: The commonly used muscle relaxant with quickest onset of action and spontaneous recovery is :

A. Vecuronium
B. Rocuronium
C. Suxamethonium (Correct Answer)
D. Atracurium

Explanation: ***Suxamethonium*** - Suxamethonium (succinylcholine) is a **depolarizing neuromuscular blocker** with the most rapid onset of action (30-60 seconds) due to its unique mechanism. - Its short duration of action and **spontaneous recovery** are due to its rapid hydrolysis by **plasma pseudocholinesterase**, making it ideal for rapid sequence intubation. *Vecuronium* - Vecuronium is an **intermediate-duration non-depolarizing neuromuscular blocker** with an onset of action typically around 3-5 minutes, which is slower than suxamethonium. - It does not undergo spontaneous recovery as rapidly as suxamethonium and often requires administration of a **reversal agent**. *Rocuronium* - Rocuronium is a **non-depolarizing neuromuscular blocker** known for its relatively rapid onset of action (60-90 seconds) among non-depolarizing agents, but it is still slower than suxamethonium. - While it can be reversed quickly with sugammadex, its **spontaneous recovery** is much slower than suxamethonium. *Atracurium* - Atracurium is an **intermediate-duration non-depolarizing neuromuscular blocker** with an onset of action (3-5 minutes) that is slower than suxamethonium. - Its metabolism involves **Hofmann elimination** and ester hydrolysis, providing a degree of organ-independent elimination, but its recovery is not as rapid or spontaneous as suxamethonium.

Question 5: Mallampati test is used for the assessment of :

A. Tongue size
B. Airway (Correct Answer)
C. Ability to protrude jaw
D. Breath hold time

Explanation: ***Airway*** - The **Mallampati test** is a widely used bedside test to assess the **visibility of the soft palate, uvula, tonsillar pillars, and tongue** within the oral cavity. - This assessment helps in predicting the **ease of intubation** and the potential for a difficult airway during anesthesia. *Tongue size* - While the Mallampati test indirectly considers the relative size of the tongue by visualizing how much of the pharynx it obstructs, its primary purpose is not to quantify **tongue size** independently. - The test assesses the **overall oral cavity geometry** for airway management, not just a single anatomical dimension. *Ability to protrude jaw* - The ability to protrude the jaw, or **mandibular protrusion**, is a different airway assessment parameter used to evaluate potential difficulty with intubation. - It is often assessed with the **upper lip bite test** or other maneuvers, not the Mallampati classification. *Breath hold time* - **Breath-hold time** is a measure related to respiratory function and patient cooperation, and it has no direct relevance to the Mallampati test. - The Mallampati test is a **visual assessment** of oral pharyngeal structures at rest or with phonation, not a dynamic respiratory measurement.