INI-CET 2007

Question 1: Which toxin is primarily responsible for epidemic dropsy?

• A. BOAA
• B. Sanguinarine (from bloodroot) (Correct Answer)
• C. Aflatoxin B1
• D. Pyrrolizidine alkaloids

Explanation: ***Sanguinarine (from bloodroot)*** - **Sanguinarine** is an alkaloid found in *Argemone mexicana* (Mexican prickly poppy/bloodroot) seeds - Epidemic dropsy occurs when **argemone oil contaminates cooking oils** (especially mustard oil) - Causes **bilateral pitting edema**, **congestive cardiac failure**, **respiratory distress**, and **glaucoma** - Toxin damages **capillary permeability**, leading to fluid leakage and widespread edema - Major outbreaks documented in India, particularly in **Bengal (1998)** and **Delhi (1998)** *BOAA* - **BOAA** (β-N-Oxalylamino-L-alanine) is found in *Lathyrus sativus* (grass pea/khesari dal) - Causes **neurolathyrism**, characterized by **spastic paraplegia** (irreversible lower limb paralysis) - Affects the **motor neurons**, not vascular permeability - Clinically distinct from epidemic dropsy with **no edema or cardiac involvement** *Aflatoxin B1* - Produced by *Aspergillus flavus* and *Aspergillus parasiticus* fungi - Potent **hepatotoxin** and **hepatocarcinogen** - Causes **acute liver necrosis** and **hepatocellular carcinoma** - Not associated with edema or epidemic dropsy *Pyrrolizidine alkaloids* - Found in plants like *Heliotropium* and *Crotalaria* species - Cause **hepatic veno-occlusive disease** (sinusoidal obstruction syndrome) - Present with **hepatomegaly**, **ascites**, and **jaundice** - Liver pathology, not the widespread peripheral edema seen in epidemic dropsy