FMGE 2012

Question 1: Cobra poison is:

• A. Vasculotoxic
• B. Myotoxic
• C. Neurotoxic (Correct Answer)
• D. Cardiotoxic

Explanation: ***Neurotoxic*** - Cobra venom contains **alpha-neurotoxins** that block **nicotinic acetylcholine receptors** at neuromuscular junctions, causing flaccid paralysis. - The primary cause of death is **respiratory failure** due to paralysis of respiratory muscles, making neurotoxicity the dominant mechanism. *Vasculotoxic* - Vasculotoxic effects are characteristic of **viper venoms**, causing bleeding, swelling, and tissue necrosis. - Cobra venom's primary action targets the **nervous system**, not blood vessels. *Myotoxic* - Myotoxic venoms directly damage **muscle tissue**, leading to rhabdomyolysis and muscle pain. - While minor muscle effects may occur, **neurotoxicity** remains the predominant and life-threatening mechanism in cobra envenomation. *Cardiotoxic* - Some cobra venoms contain **cardiotoxins**, but these are secondary to the primary neurotoxic effects. - The main cause of cardiovascular collapse is **respiratory paralysis**, not direct cardiac toxicity.