Maintenance Fluids - The Daily Gulp
Calculates daily needs for water and electrolytes to prevent dehydration and ketoacidosis in a euvolemic patient who cannot eat or drink.
- Standard "4-2-1" Rule (Hourly Rate):
- First 10 kg: $4$ mL/kg/hr
- Next 10-20 kg: $2$ mL/kg/hr
- Above 20 kg: $1$ mL/kg/hr

⭐ Increase maintenance fluids by 10-15% for each 1°C rise in body temperature above 38°C. Also account for other insensible losses like tachypnea.
Calculating Rates - Fluid Formula Fun
- "4/2/1 Rule" for Hourly Maintenance: A simple method to calculate maintenance fluid needs.
- First 10 kg: $4$ mL/kg/hr
- Next 10-20 kg: $2$ mL/kg/hr
- Above 20 kg: $1$ mL/kg/hr
- Example (75 kg adult):
- $(10 \times 4) + (10 \times 2) + (55 \times 1) = 40 + 20 + 55 = 115$ mL/hr.
- 📌 Mnemonic: "4-2-1, the fluid calculation is done!"

⭐ For febrile patients, increase maintenance fluid rates by 10-15% for each 1°C rise in body temperature above 38°C, as insensible losses are higher.
IV Fluid Types - What's in the Bag?
- Crystalloids: Salt & water solutions; primary for volume resuscitation & maintenance.
- Colloids: Large molecules (e.g., Albumin); remain in intravascular space longer.

Common Crystalloids Compared
| Fluid | Na⁺ (mEq/L) | Cl⁻ (mEq/L) | Buffer | Osmolality | Key Use |
|---|---|---|---|---|---|
| 0.9% NaCl (NS) | 154 | 154 | None | 308 | Volume expansion |
| Lactated Ringer's | 130 | 109 | Lactate | 273 | Trauma, burns |
| Plasmalyte | 140 | 98 | Acetate | 294 | Balanced resuscitation |
- Hypertonic Fluids: e.g., 3% NaCl. Used for severe, symptomatic hyponatremia.
⭐ Exam Favorite: Lactated Ringer's is generally avoided in severe traumatic brain injury (TBI). Its relative hypotonicity (273 mOsm/L) compared to plasma can worsen cerebral edema.
Adjusting Fluids - Tricky Situations
- Hypermetabolic States: Increase maintenance fluids for:
- Fever: Add 10-15% per 1°C over 37°C
- Tachypnea, significant sweating, or large wounds/burns
- Fluid Restriction States: Decrease maintenance fluids in:
- Congestive Heart Failure (CHF)
- Renal Failure (especially oliguric)
- Cirrhosis
⭐ In elderly patients or those with cardiac/renal disease, err on the side of caution. Iatrogenic fluid overload is a common and serious complication.
- The "4/2/1" rule is key for hourly maintenance: 4 mL/kg/hr for the first 10 kg, 2 mL/kg/hr for the next 10 kg, and 1 mL/kg/hr after.
- A common choice is D5 ½ NS + 20 mEq KCl to provide dextrose, prevent ketosis, and replace electrolytes.
- Increase fluids for factors like fever, tachypnea, and GI losses.
- Using hypotonic fluids alone risks iatrogenic hyponatremia, particularly in postoperative patients due to high ADH levels.
- Daily requirements are typically 1-2 mEq/kg for both sodium and potassium.
- Closely monitor urine output (>0.5 mL/kg/hr) and serum electrolytes.
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