IRB and regulatory oversight US Medical PG Practice Questions and MCQs
Practice US Medical PG questions for IRB and regulatory oversight. These multiple choice questions (MCQs) cover important concepts and help you prepare for your exams.
IRB and regulatory oversight US Medical PG Question 1: A 29-year-old man is admitted to the emergency department following a motorcycle accident. The patient is severely injured and requires life support after splenectomy and evacuation of a subdural hematoma. Past medical history is unremarkable. The patient’s family members, including wife, parents, siblings, and grandparents, are informed about the patient’s condition. The patient has no living will and there is no durable power of attorney. The patient must be put in an induced coma for an undetermined period of time. Which of the following is responsible for making medical decisions for the incapacitated patient?
- A. The spouse (Correct Answer)
- B. An older sibling
- C. Physician
- D. Legal guardian
- E. The parents
IRB and regulatory oversight Explanation: ***The spouse***
- In the absence of a **living will** or **durable power of attorney**, the law typically designates the **spouse** as the primary decision-maker for an incapacitated patient.
- This hierarchy is established to ensure decisions are made by the individual most intimately connected and presumed to understand the patient's wishes.
*An older sibling*
- Siblings are generally further down the **hierarchy of surrogate decision-makers** than a spouse or parents.
- They would typically only be considered if higher-priority family members are unavailable or unwilling to make decisions.
*Physician*
- The physician's role is to provide medical care and guidance, not to make medical decisions for an incapacitated patient when family surrogates are available.
- Physicians only make decisions in **emergency situations** when no surrogate is immediately available and treatment is immediately necessary to save the patient's life or prevent serious harm.
*Legal guardian*
- A legal guardian is usually appointed by a **court** when there is no appropriate family member available or when there is a dispute among family members.
- In this scenario, with a spouse and other close family members present, a legal guardian would not be the first choice.
*The parents*
- While parents are close family members, they are typically considered **secondary to the spouse** in the hierarchy of surrogate decision-makers for an adult patient.
- They would usually only be the decision-makers if the patient were unmarried or the spouse were unavailable.
IRB and regulatory oversight US Medical PG Question 2: A 15-year-old female presents to her family physician for an annual school physical exam and check-up. She is accompanied by her mother to the visit and is present in the exam room. The patient has no complaints, and she does not have any past medical problems. She takes no medications. The patient reports that she remains active, exercising 5 times a week, and eats a healthy and varied diet. Which of the following would be the best way for the physician to obtain a more in-depth social history, including sexual history and use of alcohol, tobacco, or recreational drugs?
- A. Disallow the mother to be present in the examination room throughout the entirety of the visit
- B. Give the patient a social history questionnaire to fill out in the exam room
- C. Ask the mother to step outside into the hall for a portion of the visit (Correct Answer)
- D. Ask the patient the questions directly, with her mother still in the exam room
- E. Speak softly to the patient so that the mother does not hear and the patient is not embarrassed
IRB and regulatory oversight Explanation: ***Ask the mother to step outside into the hall for a portion of the visit***
- This approach allows the physician to speak with the adolescent **privately and confidentially**, which is crucial for obtaining sensitive information such as sexual history, drug use, and mental health concerns.
- Adolescents are more likely to disclose personal information when their parents are not present, fostering trust and ensuring **comprehensive history-taking** vital for their well-being.
*Disallow the mother to be present in the examination room throughout the entirety of the visit*
- This is an **overly restrictive** approach that might create tension or distrust between the physician, patient, and parent, especially at the start of the visit.
- While privacy is essential for sensitive topics, parental presence can be valuable for discussing general health, family history, and **treatment plans**, especially for younger adolescents.
*Give the patient a social history questionnaire to fill out in the exam room*
- While questionnaires can be useful for gathering basic information, they often **lack the nuance** of a direct conversation and may not prompt the patient to elaborate on sensitive issues.
- Furthermore, having the mother present while the patient fills out a questionnaire on sensitive topics still **compromises confidentiality** and may lead to incomplete or dishonest answers.
*Ask the patient the questions directly, with her mother still in the exam room*
- Asking sensitive questions with a parent present is **unlikely to yield truthful and complete answers**, as adolescents may feel embarrassed, judged, or fear parental disapproval.
- This approach compromises the **confidentiality** that is fundamental to building trust with adolescent patients.
*Speak softly to the patient so that the mother does not hear and the patient is not embarrassed*
- Speaking softly is **unprofessional** and still does not guarantee privacy, as the mother might still overhear parts of the conversation.
- This method also **fails to establish true confidentiality**, which is central to building rapport and encouraging open communication with adolescent patients about sensitive topics.
IRB and regulatory oversight US Medical PG Question 3: A 28-year-old woman dies shortly after receiving a blood transfusion. Autopsy reveals widespread intravascular hemolysis and acute renal failure. Investigation reveals that she received type A blood, but her medical record indicates she was type O. In a malpractice lawsuit, which of the following elements must be proven?
- A. Duty, breach, causation, and damages (Correct Answer)
- B. Only duty and breach
- C. Only breach and causation
- D. Duty, breach, and damages
IRB and regulatory oversight Explanation: ***Duty, breach, causation, and damages***
- In a medical malpractice lawsuit, all four elements—**duty, breach, causation, and damages**—must be proven for a successful claim.
- The healthcare provider had a **duty** to provide competent care, they **breached** that duty by administering the wrong blood type, this breach **caused** the patient's death and renal failure, and these injuries constitute **damages**.
*Only duty and breach*
- While **duty** and **breach** are necessary components, proving only these two is insufficient for a malpractice claim.
- It must also be demonstrated that the breach directly led to the patient's harm and resulted in legally recognized damages.
*Only breach and causation*
- This option omits the crucial elements of professional **duty** owed to the patient and the resulting **damages**.
- A claim cannot succeed without establishing that a duty existed and that quantifiable harm occurred.
*Duty, breach, and damages*
- This option misses the critical element of **causation**, which links the provider's breach of duty to the patient's injuries.
- Without proving that the breach *caused* the damages, even if a duty was owed and breached, and damages occurred, the claim would fail.
IRB and regulatory oversight US Medical PG Question 4: A 13-year-old boy is brought to the emergency department after being involved in a motor vehicle accident in which he was a restrained passenger. He is confused and appears anxious. His pulse is 131/min, respirations are 29/min, and blood pressure is 95/49 mm Hg. Physical examination shows ecchymosis over the upper abdomen, with tenderness to palpation over the left upper quadrant. There is no guarding or rigidity. Abdominal ultrasound shows free intraperitoneal fluid and a splenic rupture. Intravenous fluids and vasopressors are administered. A blood transfusion and exploratory laparotomy are scheduled. The patient's mother arrives and insists that her son should not receive a blood transfusion because he is a Jehovah's Witness. The physician proceeds with the blood transfusion regardless of the mother's wishes. The physician's behavior is an example of which of the following principles of medical ethics?
- A. Autonomy
- B. Nonmaleficence
- C. Informed consent
- D. Justice
- E. Beneficence (Correct Answer)
IRB and regulatory oversight Explanation: ***Beneficence***
- The physician prioritized the patient's immediate survival and well-being, which is the core principle of **beneficence** (acting in the best interest of the patient).
- In cases of life-threatening emergencies, especially with minors, the duty to preserve life often outweighs other considerations like parental wishes, particularly when the patient lacks the capacity for **informed refusal**.
*Autonomy*
- The physician’s action directly overrides the mother's wishes, which would be an infringement of surrogate autonomy for a minor.
- While patient autonomy is a fundamental principle, it was superseded by the immediate need to save the patient's life.
*Nonmaleficence*
- **Nonmaleficence** means "do no harm." While transfusions have risks, refusing one in this critical situation would cause more harm (death) than performing it.
- The physician acted to prevent immediate harm (death from hemorrhage), even if it meant overriding a family's wishes regarding the specific treatment method.
*Informed consent*
- **Informed consent** requires obtaining permission from a capacitated patient (or legal guardian for a minor) after explaining the risks and benefits of a treatment.
- In this emergency scenario, the patient is a minor and incapacitated, and the urgent need for a life-saving intervention (blood transfusion for a splenic rupture) did not allow for full informed consent or negotiation with the mother, who was refusing a life-saving measure.
*Justice*
- **Justice** refers to the fair and equitable distribution of healthcare resources and equal treatment, which is not the primary ethical concern in this personal patient-physician interaction.
- The scenario focuses on the individual patient's treatment decision, not broader societal resource allocation or fairness in access to care.
IRB and regulatory oversight US Medical PG Question 5: A psychiatrist receives a call from a patient who expresses thoughts of harming his ex-girlfriend. The patient describes a detailed plan to attack her at her workplace. Which of the following represents the psychiatrist's most appropriate legal obligation?
- A. Warn the ex-girlfriend and notify law enforcement (Correct Answer)
- B. Only notify the patient's family
- C. Warn only law enforcement
- D. Maintain patient confidentiality
IRB and regulatory oversight Explanation: ***Warn the ex-girlfriend and notify law enforcement***
- This scenario directly triggers the **"duty to warn"** and **"duty to protect"** principles, primarily stemming from the **Tarasoff v. Regents of the University of California** case.
- The psychiatrist has a legal obligation to take reasonable steps to protect the identifiable victim, which includes directly warning the intended victim and informing law enforcement.
*Only notify the patient's family*
- Notifying the patient's family alone does not fulfill the **legal obligation to protect** an identifiable third party from a serious threat of harm.
- While family involvement might be part of a comprehensive safety plan, it is insufficient as the sole action in this critical situation.
*Warn only law enforcement*
- While notifying law enforcement is a crucial step, the **Tarasoff duty** specifically mandates warning the **intended victim** directly (or those who can reasonably be expected to notify the victim).
- Relying solely on law enforcement might not ensure the immediate safety of the ex-girlfriend, especially if there's a delay in their response or ability to locate her.
*Maintain patient confidentiality*
- Patient confidentiality is a cornerstone of psychiatric practice, but it is **not absolute** when there is a serious and imminent threat of harm to an identifiable individual.
- The **duty to protect** a potential victim *outweighs* the duty to maintain confidentiality in such extreme circumstances.
IRB and regulatory oversight US Medical PG Question 6: You submit a paper to a prestigious journal about the effects of coffee consumption on mesothelioma risk. The first reviewer lauds your clinical and scientific acumen, but expresses concern that your study does not have adequate statistical power. Statistical power refers to which of the following?
- A. The probability of detecting an association when no association exists.
- B. The probability of not detecting an association when an association does exist.
- C. The probability of detecting an association when an association does exist. (Correct Answer)
- D. The first derivative of work.
- E. The square root of the variance.
IRB and regulatory oversight Explanation: ***The probability of detecting an association when an association does exist.***
- **Statistical power** is defined as the probability that a study will correctly reject a false null hypothesis, meaning it will detect a true effect or association if one exists.
- A study with **adequate statistical power** is less likely to miss a real effect.
*The probability of detecting an association when no association exists.*
- This describes a **Type I error** or **false positive**, often represented by **alpha (α)**.
- It is the probability of incorrectly concluding an effect or association exists when, in reality, there is none.
*The probability of not detecting an association when an association does exist.*
- This refers to a **Type II error** or **false negative**, represented by **beta (β)**.
- **Statistical power** is calculated as **1 - β**, so this option describes the complement of power.
*The first derivative of work.*
- The first derivative of work with respect to time represents **power** in physics, which is the rate at which work is done.
- This option is a **distractor** from physics and is unrelated to statistical power in research.
*The square root of the variance.*
- The **square root of the variance** is the **standard deviation**, a measure of the dispersion or spread of data.
- This is a statistical concept but is not the definition of statistical power.
IRB and regulatory oversight US Medical PG Question 7: A 43-year-old male is transferred from an outside hospital to the neurologic intensive care unit for management of a traumatic brain injury after suffering a 30-foot fall from a roof-top. He now lacks decision-making capacity but does not fulfill the criteria for brain-death. The patient does not have a living will and did not name a specific surrogate decision-maker or durable power of attorney. Which of the following would be the most appropriate person to name as a surrogate decision maker for this patient?
- A. The patient's 67-year-old mother
- B. The patient's 22-year-old daughter (Correct Answer)
- C. The patient's girlfriend of 12 years
- D. The patient's older brother
- E. The patient's younger sister
IRB and regulatory oversight Explanation: **The patient's 22-year-old daughter**
- Most jurisdictions prioritize next of kin in a specific order, typically **spouse**, adult children, parents, and then siblings if no advanced directives exist.
- An **adult child** ranks higher in most default surrogate decision-making hierarchies than parents, siblings, or unmarried partners.
*The patient's 67-year-old mother*
- While a close family member, a **parent** is typically lower on the hierarchy of surrogate decision-makers than an adult child.
- The goal is often to find someone who best understands the patient's wishes, and adult children are generally assumed to have this insight more than parents in many legal frameworks.
*The patient's girlfriend of 12 years*
- An **unmarried partner or girlfriend**, regardless of relationship length, typically holds no legal standing as a surrogate decision-maker unless explicitly named in an advanced directive.
- Legal frameworks prioritize **blood relatives** or legally recognized unions (marriage) when no formal documentation exists.
*The patient's older brother*
- A **sibling** is usually further down the hierarchy of surrogate decision-makers after adult children and parents.
- While a family member, they would not be prioritized over a child in the absence of other directives.
*The patient's younger sister*
- Similar to the brother, a **sibling** is generally lower on the hierarchy than an adult child or parent.
- Family relationships are important, but legal protocols follow specific orders of precedence.
IRB and regulatory oversight US Medical PG Question 8: A child is learning the steps of hand hygiene. Which domain of learning is primarily involved?
- A. Cognitive
- B. Affective
- C. Psychomotor (Correct Answer)
- D. Affective & cognitive
- E. Cognitive & Psychomotor
IRB and regulatory oversight Explanation: ***Psychomotor***
- The **psychomotor domain** involves the acquisition of skills that require coordination of mental and physical activities, such as performing a physical task like hand hygiene.
- This domain focuses on the ability to carry out **physical movements** with precision and coordination.
*Cognitive*
- The **cognitive domain** primarily deals with intellectual understanding, knowledge, and problem-solving, which would involve understanding *why* hand hygiene is important, not the physical act itself.
- While essential for appreciating the *rationale* behind the steps, it does not encompass the *execution* of the skill.
*Affective*
- The **affective domain** relates to emotions, attitudes, values, and appreciation for the task, such as a child's **willingness to perform hand hygiene**.
- It involves feelings and motivations rather than the physical or intellectual mastery of a skill.
*Affective & cognitive*
- While both affective (motivation, willingness) and cognitive (understanding the importance) domains play a supportive role, neither directly addresses the **physical execution** of the learned steps.
- The primary domain for *learning the steps* (i.e., actually performing the actions) is psychomotor.
*Cognitive & Psychomotor*
- While both cognitive (understanding) and psychomotor (physical execution) domains are involved in the overall learning process, the question specifically asks about **learning the steps**, which primarily emphasizes the **psychomotor** aspect.
- The cognitive component is foundational but secondary to the actual motor skill acquisition being described.
IRB and regulatory oversight US Medical PG Question 9: A 46-year-old man comes to the physician for a follow-up evaluation one week after being discharged from the hospital for acute pancreatitis and alcohol withdrawal. He drinks 8 to 10 beers daily. When the physician asks him about his alcohol use, the patient says, “This is the second time in a year that I have experienced such severe belly pain because of my pancreas. I realize that it really could be happening because of the amount of alcohol I am drinking. However, I don't think I have the willpower to cut down.” This patient is most likely in which of the following stages of behavioral change?
- A. Action
- B. Precontemplation
- C. Preparation
- D. Maintenance
- E. Contemplation (Correct Answer)
IRB and regulatory oversight Explanation: ***Contemplation***
- The patient **acknowledges** the problem ("realize that it really could be happening because of the amount of alcohol I am drinking") and considers the link between his behavior and health issues.
- He expresses an intent to change but also feelings of **ambivalence** or a lack of willpower ("I don't think I have the willpower to cut down"), which are hallmarks of this stage.
*Action*
- This stage involves **actively modifying behavior**, environment, or experiences to overcome the problem.
- The patient has not yet taken concrete steps to cut down on alcohol, indicating he is not in this stage.
*Precontemplation*
- In this stage, individuals are **unaware or unwilling to acknowledge** that a problem exists.
- The patient clearly recognizes the problem and its consequences, ruling out precontemplation.
*Preparation*
- This stage involves **planning for change** and making small, tentative steps towards the desired behavior.
- While he expresses a desire to change, he hasn't articulated a concrete plan or taken any preparatory actions.
*Maintenance*
- This stage focuses on **sustaining the new behavior** and preventing relapse.
- The patient has not yet initiated the change, so he cannot be in the maintenance stage.
IRB and regulatory oversight US Medical PG Question 10: A 37-year-old man comes to the emergency department with his wife because of a 3-day history of severe pain in his right arm. He also reports that he cannot move his right arm. The symptoms began after the patient woke up one morning, having slept on his side. He is otherwise healthy. He works as a waiter and says that he feels exhausted from working several night shifts per week. He adds that he “can barely keep his eyes open” when looking after their daughter the next day. Since the onset of the pain, he has been unable to work and is fully dependent on his wife, who took an extra shift to make enough money to pay their monthly bills. The patient appears relaxed but only allows himself to be examined after his wife convinces him. His vital signs are within normal limits. Examination shows 1/5 muscle strength in the right arm. Reflexes are normal. He has no sensation to light touch over the entire right arm and forearm. When a pin prick test is conducted, the patient rapidly withdraws the right arm. Which of the following is the most likely diagnosis?
- A. Malingering (Correct Answer)
- B. Factitious disorder
- C. Radial nerve palsy
- D. Illness anxiety disorder
- E. Brachial neuritis
IRB and regulatory oversight Explanation: ***Malingering***
- The patient's presentation with **selective symptoms** (no sensation but rapid withdrawal from pinprick) and the **secondary gain** (avoiding work, dependence on wife for bills) are classic signs of malingering.
- The patient appears *relaxed* despite "severe pain" and only allows examination after persuasion, suggesting a **conscious fabrication of symptoms** for an external incentive.
*Factitious disorder*
- Involves the **deceptive production of symptoms** in oneself or others, but the primary motivation is to assume the **sick role**, without obvious external rewards.
- The patient in this scenario clearly benefits from avoiding work, which points away from factitious disorder.
*Radial nerve palsy*
- Would present with a specific **motor and sensory deficit pattern** corresponding to the radial nerve distribution, typically **wrist drop** and sensory loss over the dorsum of the hand.
- The patient's reported "entire right arm and forearm" sensory loss and paradoxical withdrawal to pinprick are inconsistent with a true neurological lesion.
*Illness anxiety disorder*
- Involves **preoccupations with having or acquiring a serious illness** despite minimal or no somatic symptoms, and is characterized by high levels of anxiety about health.
- This patient's presentation is more about symptom production for an external gain rather than anxiety about disease or actual illness.
*Brachial neuritis*
- Typically causes **severe pain** followed by **weakness and muscle atrophy** in the muscles innervated by the brachial plexus, but the sensory loss typically follows a dermatomal or nerve distribution.
- The reported global sensory loss in the entire arm and forearm, with preserved reflexes and paradoxical withdrawal to pinprick, is inconsistent with a specific nerve inflammation or damage.
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