Pericardial Diseases

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Pericardial Anatomy & Effusion - Sac's Fluid Saga

  • Pericardial Sac:
    • Layers: Outer fibrous; inner serous (parietal & visceral/epicardium).
    • Space: Between serous layers; normal fluid <50ml (lubrication).
    • Innervation: Phrenic nerve (pain referral to shoulder).
  • Pericardial Effusion: Abnormal fluid accumulation (>50ml).
    • Types: Transudative (e.g., CHF) or Exudative (e.g., infection, malignancy).
    • Key Causes: TB, viral infections, malignancy, uremia, autoimmune (SLE), Dressler's syndrome.
    • Imaging Findings:
      • Echocardiography: Gold standard. Detects ≥15-20ml; assesses hemodynamics.
      • CXR: Globular heart (see below); epicardial fat pad sign ("Oreo cookie sign").

        Water bottle sign (globular cardiac silhouette) on CXR is a classic indicator of large pericardial effusion (typically >250ml).

      • CT/MRI: For complex/loculated effusions, pericardial thickening. Pericardial Effusion: CXR Water Bottle Sign & CT

Cardiac Tamponade - Pressure Cooker Crisis

Life-threatening compression from rapid pericardial fluid accumulation, impairing diastolic filling and reducing cardiac output.

  • Key Signs:
    • 📌 Beck's Triad: 3 D's - Distant/Muffled heart sounds, Distended jugular veins (↑ JVP), Decreased arterial pressure (Hypotension).
    • Pulsus paradoxus: Inspiratory ↓ SBP >10 mmHg.
    • Tachycardia, dyspnea.
  • Diagnosis:
    • Echocardiography (Gold Standard):

      Right atrial diastolic collapse is the earliest and most sensitive echocardiographic sign of cardiac tamponade.

      • Also: RV diastolic collapse, swinging heart, plethoric IVC (no inspiratory collapse).
    • ECG: Low voltage QRS complexes, electrical alternans.
    • CXR: May show enlarged, globular heart ("water bottle sign") with large effusions.
  • Management:
    • Urgent pericardiocentesis (therapeutic & diagnostic).
    • IV fluids (temporizing).

Echocardiogram: Right atrial collapse in cardiac tamponade

Acute Pericarditis - Heart's Fiery Rub

  • Pericardial inflammation; often idiopathic/viral (Coxsackie B).
  • Triad: Pleuritic/postural chest pain (relieved sitting up), pericardial friction rub, ECG changes.
  • ECG Stages (📌 P-R-E-S-T Mnemonic):
    • PR depression (except aVR/V1).
    • Reciprocal ST depression (aVR/V1).
    • Elevation of ST segments (widespread, concave).
    • ST normalization.
    • T wave inversion.
  • Dx: ECG, Echo (effusion?), ↑ESR/CRP. CXR often normal.
  • Rx: NSAIDs (Ibuprofen 600-800mg TID) + Colchicine (0.5-0.6mg BID x 3mo) to ↓ recurrence. Steroids if refractory.
  • Widespread concave ST elevation and PR segment depression (except in aVR, V1 where PR elevation and ST depression may be seen) are hallmark ECG findings in acute pericarditis. ECG: ST elevation and PR depression in pericarditisoka

Constrictive Pericarditis - Heart's Rigid Cage

Fibrotic, calcified pericardium restricts diastolic filling.

  • Etiology: TB (India), post-viral, post-surgery, radiation.
  • Clinical Signs: RHF symptoms, pericardial knock, 📌 Kussmaul's sign (↑JVP on inspiration; K in Konstriction), Friedreich's sign.
  • Investigations:
    • CXR: Calcification.
    • Echo: Thick pericardium, septal bounce, resp. variation.
    • CT/MRI: Pericardial thickness >4mm.
    • Cath: Equalized diastolic pressures (within 5 mmHg), "dip and plateau" sign.
  • Treatment: Pericardiectomy.

⭐ In India, tuberculosis is a leading cause of constrictive pericarditis, often presenting with significant pericardial calcification visible on CXR or CT.

Table: CP vs. RCM

FeatureConstrictive Pericarditis (CP)Restrictive Cardiomyopathy (RCM)
PericardiumThick, calcifiedNormal
MyocardiumNormalStiff, infiltrated
Pericardial Thick.>4mmNormal
Atrial SizeMildly ↑ / NormalMarkedly ↑
BNPMildly ↑ / NormalMarkedly ↑
Septal BouncePresentAbsent
Diastolic PressuresEqualizedLVEDP > RVEDP (>5mmHg)

High‑Yield Points - ⚡ Biggest Takeaways

  • Constrictive Pericarditis: Features pericardial calcification, Kussmaul's sign, and diastolic septal bounce (Echo/MRI).
  • Cardiac Tamponade: Presents with Beck's triad, pulsus paradoxus; Echo shows diastolic RV/RA collapse.
  • Pericardial Effusion: Shows "water-bottle" heart (CXR), electrical alternans (ECG), and swinging heart (Echo).
  • Acute Pericarditis: Diagnosed by friction rub, diffuse ST elevation, and PR depression on ECG.
  • MRI/CT: Best for pericardial thickness, inflammation, cysts, and masses.
  • Pericardial Cysts: Typically benign, most common at the right cardiophrenic angle.

Practice Questions: Pericardial Diseases

Test your understanding with these related questions

Identify the ECG given below?

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Flashcards: Pericardial Diseases

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The X-ray shows _____ sign which is suggestive of _____ anomalous pulmonary venous return.

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The X-ray shows _____ sign which is suggestive of _____ anomalous pulmonary venous return.

Scimitar; partial

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