Trichotillomania

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Definition & Epidemiology - Hair Havoc

  • Definition: Recurrent pulling out of one's own hair, leading to hair loss.
  • Accompanied by repeated attempts to ↓ or stop hair pulling.
  • Causes clinically significant distress or impairment.
  • Not attributable to another medical condition (e.g., dermatological).
  • Not better explained by another mental disorder (e.g., body dysmorphic disorder).

Trichotillomania hair loss patches

  • Prevalence: 12-month prevalence in adults & adolescents is 1-2%.
  • Age of Onset: Commonly coincides with or follows puberty.
  • Gender: Females are more frequently affected than males (approx. 10:1 ratio).

Exam Favourite: Trichotillomania is classified under Obsessive-Compulsive and Related Disorders in DSM-5, not as an impulse control disorder as in ICD-10 (F63.3).

Clinical Features - Telltale Tufts

  • Hair Loss Pattern:
    • Irregular, patchy alopecia; hairs of varying lengths (key diagnostic feature).
    • Broken hairs (blunt/tapered ends); "telltale tufts" of short, stubbly hair.
    • 📌 "Friar Tuck" sign: characteristic peripheral scalp sparing.
  • Common Sites: Scalp (vertex/crown), eyebrows, eyelashes. Less frequent: axillary, pubic, beard.
  • Associated Behaviors:
    • Rituals: inspecting root, twirling, mouthing; trichophagia (~20%), risk of trichobezoar.
    • Pulling: focused (tension relief) or automatic (unaware, e.g., reading).
  • Skin Findings: Typically non-scarring. Erythema, excoriations, black dots (broken hairs).

⭐ Hairs of varying lengths in alopecia patches distinguish TTM from alopecia areata (smooth patches, exclamation mark hairs).

Trichotillomania scalp hair findings

Diagnosis & DDx - Spotting Signs

DSM-5 Based Diagnosis (📌 H.A.I.R.S.):

  • Hair pulling: Recurrent, resulting in hair loss.
  • Attempts: Repeated efforts to decrease/stop pulling.
  • Impairment: Clinically significant distress or functional impairment.
  • Ruled out: Not due to other medical conditions (e.g., dermatological).
  • Separate: Not better explained by another mental disorder (e.g., BDD, OCD).

Key Differentiators (DDx):

  • Alopecia Areata: Autoimmune; smooth patches; "!" hairs.
  • Tinea Capitis: Fungal; scaling, black dots, broken hairs; +KOH.
  • OCD: Pulling ritualistic, secondary to unrelated obsession/symmetry; not for tension relief.
  • BDD: Hair removal to "fix" perceived appearance defect.

⭐ Trichobezoars (hairballs) from ingesting pulled hair can cause serious GI complications like obstruction.

Treatment Approaches - Taming Urges

  • Primary Goal: Reduce hair pulling, manage urges, improve psychosocial functioning.
  • First-line Therapy: Behavioral Interventions
    • Habit Reversal Training (HRT): Core component; involves awareness training & competing response.
    • Cognitive Behavioral Therapy (CBT): Addresses dysfunctional thoughts & beliefs.
    • Acceptance and Commitment Therapy (ACT).
  • Pharmacotherapy: Adjunctive or for severe/refractory cases.
    • SSRIs (e.g., Fluoxetine, Sertraline): Often initial choice, variable efficacy.
    • Clomipramine (TCA): Strongest evidence; dose 25-250 mg/day. Monitor side effects.
    • N-acetylcysteine (NAC): Glutamate modulator; dose 1200-2400 mg/day.
    • Atypical Antipsychotics (e.g., Olanzapine, Risperidone): Low dose for refractory cases.

⭐ Clomipramine has demonstrated the most robust efficacy among pharmacological agents for trichotillomania in clinical trials, though often reserved due to its side effect profile compared to SSRIs or NAC.

Comorbidities & Complications - Tangled Troubles

  • Psychiatric:
    • MDD (Major Depressive Disorder)
    • Anxiety disorders (esp. GAD, Social Anxiety)
    • OCD
    • Excoriation (skin-picking) disorder
    • Substance use disorders
  • Physical:
    • Trichobezoars (hairballs) → GI obstruction, malnutrition
    • Skin irritation, infection
    • Dental damage (from biting hair)
    • Carpal tunnel syndrome (repetitive motion)

⭐ Trichobezoars are a serious, potentially life-threatening complication requiring surgical intervention in some cases of trichotillomania with trichophagia (hair eating).

High‑Yield Points - ⚡ Biggest Takeaways

  • Recurrent hair pulling causes significant hair loss, despite repeated unsuccessful attempts to stop.
  • Preceded by increasing tension, followed by relief, pleasure, or gratification.
  • Common sites: scalp, eyebrows, eyelashes; rarely involves trichophagia (hair eating).
  • High comorbidity with anxiety disorders, MDD, and excoriation (skin-picking) disorder.
  • Treatment options include SSRIs (fluoxetine, clomipramine) and N-acetylcysteine.
  • Cognitive Behavioral Therapy (CBT), especially Habit Reversal Training (HRT), is the mainstay.
  • Typical onset is childhood or early adolescence; can be chronic if untreated.

Practice Questions: Trichotillomania

Test your understanding with these related questions

A child presents with multiple patchy areas of hair loss, scales, and itching. The sister also had similar lesions. What is the most likely diagnosis?

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Flashcards: Trichotillomania

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First-line treatment for OCD includes _____ + SSRIs (preferred) or clomipramine

TAP TO REVEAL ANSWER

First-line treatment for OCD includes _____ + SSRIs (preferred) or clomipramine

CBT

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