Sensory Processing

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Sensory Receptors & Coding - The Body's Detectives

  • Receptors: Specialized transducers converting stimuli to electrical signals.
  • Types: (📌 Mnemonic: Many Tall Nurses Prefer Coffee)
    • Mechanoreceptors (touch, pressure)
    • Thermoreceptors (temperature)
    • Nociceptors (pain)
    • Photoreceptors (light)
    • Chemoreceptors (taste, smell, $O_2$, $CO_2$)
  • Receptor Potential: Graded, local electrical response; if threshold met → AP.
  • Sensory Coding:
    • Modality: Labeled Line Principle.
    • Intensity: AP frequency & # active receptors. Weber-Fechner Law: $S = K \log R$.
    • Duration: Receptor adaptation (phasic/tonic).
    • Location: Receptive fields; lateral inhibition (sharpens contrast). Sensory receptor types and connections

Muller's Law (Law of Specific Nerve Energies): Sensation depends on pathway activated, not stimulus type.

Somatosensory Pathways - Touch, Pain & Position

  • Dorsal Column-Medial Lemniscus (DCML): Fine touch, vibration, proprioception.
    • 1° Neuron: Enters SC, ascends ipsilaterally (Fasciculus Gracilis - lower limb; Cuneatus - upper limb). Synapse: N. Gracilis/Cuneatus (Medulla).
    • 2° Neuron: Decussates in medulla (internal arcuate fibers) → Medial Lemniscus. Synapse: VPL (Thalamus).
    • 3° Neuron: VPL → Primary Somatosensory Cortex.
  • Anterolateral System (ALS) / Spinothalamic: Pain, temperature, crude touch.
    • 1° Neuron: Synapse in Dorsal Horn (e.g., Substantia Gelatinosa).
    • 2° Neuron: Decussates in SC (Anterior White Commissure) → Spinothalamic Tract. Synapse: VPL (Thalamus).
    • 3° Neuron: VPL → Primary Somatosensory Cortex.
  • Spinocerebellar Tracts: Unconscious proprioception to cerebellum.

Spinal cord cross-section with ascending/descending tracts

⭐ Brown-Séquard Syndrome: Spinal cord hemisection. Ipsilateral loss of fine touch/proprioception, contralateral loss of pain/temperature below lesion level.

Special Senses I - Vision & Hearing Hits

  • Vision
    • Photoreceptors: Rods (scotopic, rhodopsin, night vision), Cones (photopic, iodopsin, color, fovea).
    • Pathway: Retina → Optic N. (CN II) → Chiasm (nasal decussation) → Optic Tract → LGN (Thalamus) → Optic Radiation → Visual Cortex (Occipital). 📌 LGN for Light.
*   Pupillary light reflex: Afferent **CN II**, Efferent **CN III**.
*   Accommodation: Ciliary muscle contraction (**CN III**), ↑lens convexity, miosis.
*   Refractive errors: Myopia (concave lens), Hyperopia (convex lens).
  • Hearing
    • Organ of Corti: Hair cells (mechanoreceptors).
    • Pathway: Cochlear N. (CN VIII) → Cochlear Nuclei → Superior Olivary Complex (sound localization) → Lateral Lemniscus → Inferior Colliculus → MGN (Thalamus) → Auditory Cortex (Temporal). 📌 MGN for Music.
    • Middle Ear Ossicles: Malleus, Incus, Stapes (amplification).
    • Tests: Rinne/Weber differentiate conductive vs. sensorineural hearing loss.

    ⭐ Meyer's loop (inferior optic radiation) lesion causes contralateral superior homonymous quadrantanopia ("pie in the sky"). Visual pathway lesions and visual field defects

Special Senses II - Chemical Senses & Balance Beats

  • Olfaction (Smell):
    • Receptors: Olfactory receptor cells (CN I) in olfactory epithelium; GPCRs.
    • Pathway: Olfactory bulb → piriform cortex, amygdala.
    • 📌 Unique: Neurons regenerate.
  • Gustation (Taste):
    • Receptors: Taste buds (gustatory cells) on papillae.
    • Tastes: Sweet, Sour, Salty, Bitter, Umami (GPCRs for Sweet, Bitter, Umami).
    • Nerves: CN VII, IX, X → solitary nucleus → VPM thalamus → insula.
  • Vestibular System (Balance):
    • Organs: Utricle & Saccule (linear acceleration; otoliths); Semicircular canals (angular acceleration; cupula).
    • Receptors: Hair cells.
    • Key: Vestibulo-ocular reflex (VOR) for gaze stability.

⭐ Olfactory receptor neurons are unique as they are replaced throughout life (neurogenesis). Olfactory and Gustatory Pathways

High‑Yield Points - ⚡ Biggest Takeaways

  • Receptor potentials are graded; summation leads to action potentials.
  • Phasic receptors (e.g., Pacinian) adapt rapidly; tonic receptors (e.g., Ruffini) adapt slowly.
  • DCML pathway: fine touch, vibration, proprioception. ALS pathway: pain, temperature, crude touch.
  • Thalamus (VPL/VPM) is the key sensory relay (except olfaction).
  • Somatosensory cortex (postcentral gyrus) has somatotopic organization (homunculus).
  • Lateral inhibition sharpens sensory discrimination and contrast.
  • Labeled line principle: specific pathways for specific modalities.

Practice Questions: Sensory Processing

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Sensory fibers from the taste buds in the back of the tongue and soft palate travel along:

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Flashcards: Sensory Processing

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The axon reflex _____ after total sympathectomy

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The axon reflex _____ after total sympathectomy

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