Bronchiolitis

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Bronchiolitis Basics - Wheezy Wee Ones

  • Acute viral Lower Respiratory Tract Infection (LRTI) of small airways (bronchioles).
  • Primarily affects infants < 2 years; peak incidence 2-6 months.
  • Clinical features: Coryza, cough, tachypnea, expiratory wheeze, crackles, respiratory distress.
  • Most common cause: Respiratory Syncytial Virus (RSV) - accounts for ~70-80% of cases.
  • Other viral culprits: Rhinovirus, Parainfluenza, Adenovirus, Human Metapneumovirus (hMPV).
  • Seasonal pattern: Predominantly occurs during winter and early spring.

⭐ RSV is the leading cause of bronchiolitis and pneumonia in infants worldwide.

Pathophysiology & Risk Factors - Tiny Tube Trouble

  • Pathophysiology: Viral infection (RSV predominant) inflames bronchioles. Leads to epithelial necrosis, edema, ↑mucus & debris. Causes airway narrowing/obstruction, air trapping, atelectasis, V/Q mismatch.
  • Risk Factors:
    • Age <6 months (peak 2-6 months)
    • Prematurity (<37 weeks), Low Birth Weight (LBW)
    • Chronic Lung Disease (e.g., BPD)
    • Congenital Heart Disease (hemodynamically significant)
    • Immunodeficiency
    • Environmental: Passive smoking, Daycare, Crowding
    • 📌 Prematurity, Age <6m, Chronic conditions (lung/heart), Environmental (smoke/daycare) = PACE

Bronchiolitis Pathophysiology: Normal vs Inflamed Bronchiole

⭐ RSV is the most common cause (>50% of cases), particularly during winter outbreaks.

Clinical Features & Severity - Coughs & Cries

  • Initial Phase (1-3 days): Coryza, mild cough, low-grade fever.

  • Progressive Phase (LRTI):

    • Worsening paroxysmal cough, often with post-tussive emesis.
    • Tachypnea (typically >50-60/min).
    • Auscultation: Diffuse bilateral wheezes (often polyphonic, expiratory > inspiratory), fine inspiratory crackles.
    • Increased Work of Breathing (WOB): Nasal flaring, expiratory grunting, intercostal/subcostal/suprasternal retractions.
    • Feeding difficulties, dehydration risk, irritability.
    • Apneic episodes: Significant risk in young infants (<2 months, esp. <6 weeks) and premature babies.
  • Severity Classification:

> ⭐ Apnea may be the *sole* presenting feature in very young infants (<**2** months), especially those born prematurely.

Diagnosis & Differentials - Clinical Clues

  • Age < 2 yrs (peak 3-6 mo).
  • Viral prodrome (coryza, cough) → resp. distress (tachypnea, retractions, nasal flaring).
  • Auscultation: Diffuse wheeze & fine inspiratory crackles.
  • Low-grade fever; apnea risk in young/premature infants.
  • Differentials:
    • Asthma: Recurrent, older age, good bronchodilator response.
    • Pneumonia: High fever, focal chest signs.
    • Foreign Body Aspiration (FBA): Sudden onset, unilateral findings.
    • Pertussis: Paroxysmal cough, inspiratory whoop.

⭐ First episode of wheezing in a child < 2 years, especially < 12 months, is highly suggestive, particularly during RSV season.

Management & Prevention - Supportive Steps

  • Goals: Oxygenation (SpO2 >90-92%), hydration.
  • Oxygen: Humidified if SpO2 < 90-92%.
  • Fluids: Oral preferred. IV if poor intake, dehydration, or ↑WOB (work of breathing).
  • Nasal Suction: Gentle, pre-feeds; saline drops PRN.
  • Fever: Paracetamol if >38.5°C or distress.
  • Monitor: Respiratory status (RR, effort, SpO2), hydration, feeding.

⭐ Routine bronchodilators, corticosteroids, or antibiotics are NOT recommended in typical bronchiolitis; they lack proven clinical benefit.

  • Prevention:
    • Hand hygiene, avoid smoke exposure.
    • Breastfeeding.
    • Palivizumab for high-risk infants (prematurity <29wks, CLD, significant CHD).

High-Yield Points - ⚡ Biggest Takeaways

  • RSV is the most common cause, primarily affecting infants < 2 years old.
  • Characterized by viral prodrome followed by wheezing, cough, and respiratory distress.
  • Diagnosis is mainly clinical; CXR may show hyperinflation and atelectasis.
  • Treatment is supportive: oxygen, hydration, and nasal suctioning.
  • Bronchodilators and steroids are not routinely recommended.
  • Palivizumab for prophylaxis in high-risk infants (e.g., prematurity, CLD).
  • Watch for apnea, especially in young infants or those born prematurely.
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Practice Questions: Bronchiolitis

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2 months old child having birth weight 2kg, with poor feeding, very sleepy and wheezing. The diagnosis is?

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Flashcards: Bronchiolitis

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_____ presents with a hoarse, 'seal bark' cough and inspiratory stridor

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_____ presents with a hoarse, 'seal bark' cough and inspiratory stridor

Laryngotracheobronchitis (croup)

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Bronchiolitis - Free Indian Medical PG Review