Pericardial Disease

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Pericardial Basics - Heart's Cozy Coat

Pericardium Anatomy

  • Layers & Space:
    • Outer: Tough Fibrous Pericardium.
    • Inner: Serous Pericardium:
      • Parietal layer (lines fibrous).
      • Visceral layer (epicardium; on heart surface).
    • Pericardial Cavity: Space between serous layers; contains 15-50 mL of lubricating fluid.
  • Core Functions:
    • Limits acute cardiac distension.
    • Reduces friction during cardiac motion.
    • Barrier against infection/inflammation.

⭐ The pericardium is composed of an outer fibrous layer and an inner serous layer (parietal and visceral, with the pericardial cavity between them).

Acute Pericarditis - Chest Pain Drama

  • Etiology: Most common: Idiopathic, Viral (Coxsackie B). Others: Uremia, Post-MI (Dressler's syndrome), TB, Autoimmune (SLE), Neoplastic.
  • Clinical: Sharp, pleuritic chest pain (relieved sitting up/leaning forward, worse supine). Fever. Pericardial friction rub (triphasic, transient).
  • ECG: Diffuse concave ST elevation & PR depression. Stages:
    • I: Widespread ST↑, PR↓
    • II: ST/PR normalize
    • III: T-wave inversions
    • IV: ECG normalizes ECG: ST elevation and PR depression in pericarditis
  • Diagnosis: Requires ≥2 of 4 criteria:
    • Typical pericarditic chest pain
    • Pericardial friction rub
    • Characteristic ECG changes (new ST↑ or PR↓)
    • New or worsening pericardial effusion

⭐ The most common causes of acute pericarditis are idiopathic and viral infections.

  • Management: NSAIDs (e.g., ibuprofen) + Colchicine (reduces recurrence). Corticosteroids for refractory cases or specific indications (e.g., autoimmune, uremic if NSAIDs fail/contraindicated).

Effusion & Tamponade - Squeezing The Pump

  • Pericardial Effusion: Fluid >50mL in pericardial space.
  • Cardiac Tamponade: Effusion causing hemodynamic compromise.
    • Pathophysiology: ↑ Intrapericardial pressure → ↓ Venous return → ↓ Diastolic filling → ↓ Stroke volume → Hypotension, shock.
    • Clinical (Tamponade):
      • Beck's Triad: Hypotension, ↑JVP (Distended Neck Veins), Muffled heart sounds. 📌 3 D's: Decreased Arterial Pressure, Distended Jugular Veins, Distant Heart Sounds.
      • Pulsus Paradoxus: >10 mmHg SBP fall on inspiration.
      • Tachycardia, dyspnea.
    • Diagnosis:
      • Echocardiography (key): Effusion size, diastolic RV/RA collapse, swinging heart.
      • ECG: Low voltage QRS, electrical alternans.
    • Management:
      • Urgent Pericardiocentesis: Diagnostic & therapeutic for tamponade.
      • IV fluids (temporizing).
      • Treat underlying cause.

⭐ Electrical alternans on ECG is highly suggestive of large pericardial effusion and cardiac tamponade.

Echocardiogram of cardiac tamponade

Constrictive Pericarditis - Heart In A Vise

Thickened, fibrotic, often calcified pericardium restricts diastolic filling.

  • Etiology: Idiopathic, post-surgery, radiation, TB, recurrent pericarditis.
  • Pathophysiology: Impaired ventricular filling → equalization of diastolic pressures.
  • Clinical: RHF (edema, ascites), dyspnea.
    • Pericardial knock (early diastolic).
    • Kussmaul's sign (paradoxical ↑JVP on inspiration).
    • Friedreich's sign (rapid y-descent JVP).
  • Diagnosis:
    • Echo: Septal bounce, respiratory variation in inflow.
    • CT/MRI: Pericardial thickening >4mm, calcification.
    • Cath: Dip-and-plateau (square root sign).

⭐ Kussmaul's sign, a paradoxical rise in jugular venous pressure during inspiration, is a characteristic finding in constrictive pericarditis.

  • Management: Pericardiectomy.

CP and RCM: Approach to Diagnosis

CP vs. Restrictive Cardiomyopathy (RCM)

FeatureConstrictive Pericarditis (CP)Restrictive Cardiomyopathy (RCM)
PathologyPericardial (thick, fibrotic)Myocardial (stiff, infiltrated)
Diastolic FillingExternal constraintStiff myocardium
PressuresEqualized diastolicLV > RV diastolic
Pericardial KnockPresentAbsent
Kussmaul's SignCommonRare
Pericardial Thickening>4mm, calcificationNormal

High‑Yield Points - ⚡ Biggest Takeaways

  • Fibrinous pericarditis: most common, post-MI (Dressler's syndrome), uremia; key sign is friction rub.
  • Constrictive pericarditis: impaired diastolic filling; look for Kussmaul's sign, pericardial knock.
  • Cardiac tamponade: Beck's triad (hypotension, JVD, muffled sounds) and pulsus paradoxus are classic.
  • Acute pericarditis: commonly viral (Coxsackie B); causes sharp chest pain, diffuse ST elevation.
  • Tuberculous pericarditis: a major cause of chronic constrictive pericarditis in endemic areas.
  • Uremia and malignancy are important non-infectious causes of pericarditis and large effusions respectively.

Practice Questions: Pericardial Disease

Test your understanding with these related questions

A patient presents with engorged neck veins, a blood pressure of 80/50 mmHg, and a pulse rate of 100 beats per minute following blunt trauma to the chest. The diagnosis is:

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Flashcards: Pericardial Disease

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One complication of _____ is high-output heart failure due to formation of AV shunts in bone

TAP TO REVEAL ANSWER

One complication of _____ is high-output heart failure due to formation of AV shunts in bone

Paget disease of bone

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