Degenerative Spinal Conditions

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Overview of Degeneration - Wear & Tear Tales

  • Progressive, age-related structural failure from chronic biomechanical stress ("wear & tear").
  • Key targets: Intervertebral discs (IVD), facet joints, vertebral endplates, ligaments.
  • Pathophysiology Highlights:
    • IVD: Initial ↓proteoglycans & water (nucleus pulposus) → ↓disc height, desiccation → annular tears, fissures → herniation.
    • Facet Joints (Zygapophyseal): Cartilage erosion → inflammation → osteophyte formation (spondylosis) → arthropathy, hypertrophy.
    • Ligaments: Hypertrophy (esp. ligamentum flavum), ossification.
  • Clinical Sequelae: Segmental instability, nerve root impingement (radiculopathy), spinal stenosis, myelopathy, chronic axial pain.

⭐ Most common initial change in degenerative disc disease is loss of proteoglycans and water content in the nucleus pulposus.

Sagittal MRI Lumbar Spine Degenerative Disc Disease

Cervical Spondylosis - Cranky Neck Crisis

  • Degenerative cascade affecting cervical discs, vertebrae, facet joints.
  • Pathophysiology: Disc desiccation & collapse → osteophytes → ↓canal/foraminal space.
  • Clinical Syndromes:
    • Axial Neck Pain: Chronic, activity-related.
    • Cervical Radiculopathy: Unilateral arm pain, paresthesia, weakness. Positive Spurling's test.
    • Cervical Myelopathy: Insidious onset. Gait disturbance (spastic), clumsiness, Lhermitte's sign, Hoffman's sign. Bowel/bladder changes late.
  • Diagnosis:
    • X-ray: ↓Disc height, osteophytes, foraminal narrowing.
    • MRI: Definitive for neural compression. Cervical spondylotic myelopathy pathophysiology
  • Management:
    • Conservative: NSAIDs, physiotherapy, cervical collar.
    • Surgical: Decompression (ACDF, laminectomy) for progressive myelopathy or failed conservative Rx for radiculopathy.

⭐ Nurick scale is commonly used to grade the severity of cervical spondylotic myelopathy.

Lumbar Degeneration - Low Back Breakdown

  • Core Issues: Age-related wear & tear of lumbar discs, facets, ligaments. Leads to Low Back Pain (LBP), radiculopathy (e.g., sciatica), and/or neurogenic claudication.
  • Key Conditions:
    • Disc Herniation: Nucleus pulposus extrusion. Common at L4-L5, L5-S1. Positive Straight Leg Raise (SLR).
    • Lumbar Spinal Stenosis (LSS): Central canal or foraminal narrowing.
    • Degenerative Spondylolisthesis: Anterior vertebral slippage, often L4-L5.
  • Diagnosis: History, neuro exam. X-ray (osteophytes, ↓disc height). MRI is gold standard.

⭐ The "shopping cart sign" (symptoms improve with leaning forward) is characteristic of lumbar spinal stenosis. Lumbar spine MRI: Disc herniation and stenosis

  • Management Approach:

Clinical Approach - Spine Sleuth & Fix

  • History: Focus on red flags (📌 PINNT: Progressive deficit, Incontinence, Night pain/fever/weight loss, Numbness/weakness (new/progressive), Trauma). Pain: onset, character, radiation, aggravating/relieving factors.
  • Exam:
    • Observe: Gait, deformity (scoliosis, kyphosis).
    • Palpate: Tenderness.
    • Assess: ROM.
    • Neuro: Motor (power 0-5), Sensory (dermatomes), Reflexes. Special tests (SLR, Lasegue's, Femoral stretch, Spurling's).
  • Investigations:
    • X-ray: Initial (AP/Lat), dynamic views for instability.
    • MRI: Gold standard for discs, nerves, cord.
    • CT: For bony detail, fractures, severe stenosis.
  • Management Principles:
    • Conservative: Rest, analgesia (NSAIDs), physiotherapy, epidural injections.
    • Surgical: Indications: progressive neuro deficit, intractable pain, instability, failure of conservative Rx.

      ⭐ Cauda equina syndrome is a surgical emergency requiring urgent decompression.

Lumbar disc herniation MRI

High‑Yield Points - ⚡ Biggest Takeaways

  • Lumbar spondylosis is most common, affecting L4-L5 & L5-S1 levels.
  • Cervical spondylosis presents with radiculopathy (nerve root) or myelopathy (cord compression).
  • Neurogenic claudication, relieved by flexion, is key for lumbar spinal stenosis.
  • MRI is the gold standard for diagnosis and assessing severity.
  • Conservative management (rest, NSAIDs, physiotherapy) is the initial approach.
  • Surgical decompression is for progressive neurological deficits or intractable pain.
  • Degenerative spondylolisthesis commonly occurs at L4-L5.

Practice Questions: Degenerative Spinal Conditions

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Flashcards: Degenerative Spinal Conditions

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_____ is characterized by eburnation (polishing) of the subchondral bone

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_____ is characterized by eburnation (polishing) of the subchondral bone

Osteoarthritis

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