Physiology of Smell and Taste

Physiology of Smell and Taste

Physiology of Smell and Taste

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Physiology of Smell and Taste - Scent Structures & Signals

  • Olfactory Epithelium: Located in nasal cavity roof. 📌 Mnemonic: "Old Sexy Basal Bows" for cell types (Olfactory, Supporting, Basal, Bowman's). Contains:
    • Olfactory Receptor Neurons (ORNs): Bipolar neurons; cilia detect odorants. Axons form CN I. Regenerate every 30-60 days.
    • Supporting (Sustentacular) Cells: Provide structural & metabolic support.
    • Basal Cells: Stem cells for ORNs.
    • Bowman's Glands: Secrete mucus to dissolve odorants.

Olfactory epithelium and bulb anatomy

  • Odorant Receptors: Approximately 400 types of G-protein coupled receptors (GPCRs) on ORN cilia. Each ORN typically expresses one receptor type.

  • Olfactory Transduction Pathway:

  • Olfactory Bulb: First processing site. ORN axons synapse in glomeruli with mitral and tufted cells. Each glomerulus receives input from ORNs expressing the same receptor type.

⭐ The olfactory pathway is unique as many of its fibers bypass the thalamus to directly reach the primary olfactory cortex (e.g., piriform cortex, amygdala).

Olfactory Pathways & Clinicals - Nose Notes & Neuro Nods

  • ORNs (epithelium) → cribriform plate → olfactory bulb (glomeruli). 1st order.
  • Mitral/Tufted cells (2nd order) → olfactory tract → primary olfactory cortex (piriform, amygdala, entorhinal).
    • Unique: NO direct thalamic relay to primary cortex for conscious smell.
  • Secondary: Orbitofrontal cortex (via MDN thalamus for discrimination), hippocampus. Olfactory pathway from nose to brain
  • Clinicals:
    • Anosmia: Loss of smell. Causes: URI, trauma, polyps, Kallmann Syn. 📌 COVID-19 is a key cause.
    • Hyposmia (↓), Parosmia (distorted), Phantosmia (hallucination).
    • Olfactory groove meningioma: Can cause progressive anosmia.

⭐ Foster Kennedy Syndrome: Olfactory groove meningioma → ipsilateral anosmia & optic atrophy, contralateral papilledema.

Gustatory System & Transduction - Taste Bud Breakdown

Anatomy of taste buds and lingual papillae

  • Taste Buds: Sensory organs on lingual papillae (fungiform, foliate, circumvallate), palate, epiglottis. Each 50-100 cells.

    • Cells: Type I (support, salt?), II (receptors: sweet, umami, bitter - GPCRs), III (presynaptic: sour - ion channels), IV (basal).
  • Papillae Types:

    • Fungiform (anterior), Foliate (lateral), Circumvallate (posterior, most buds). Filiform (no buds, mechanical).
  • Taste Transduction Table:

    ModalityReceptor(s)Pathway Key Steps
    SweetT1R2+T1R3 (GPCR)Gα-gustducin → ↑cAMP
    UmamiT1R1+T1R3 (GPCR)Gα-gustducin → ↑IP₃/DAG → $Ca^{2+}$ release
    BitterT2Rs (GPCR)Gα-gustducin → ↑IP₃/DAG → $Ca^{2+}$ release
    SaltyENaC$Na^{+}$ influx → Depolarization
    SourOTOP1/PKD2L1$H^{+}$ influx / $K^{+}$ block → Depolarization

Fact: Circumvallate papillae (V-shape, posterior tongue) house the most taste buds.

Gustatory Pathways & Flavor - Tongue Trails & Taste Twists

  • Taste Innervation & Central Route:
    • Anterior 2/3 tongue: CN VII (Chorda tympani).
    • Posterior 1/3 tongue: CN IX.
    • Epiglottis/Palate: CN X.
    • All synapse in Nucleus of Solitary Tract (NST), medulla.
    • NST → Thalamus (VPM) → Gustatory Cortex (Insula, Frontal Operculum).
  • Flavor: More Than Taste:
    • Crucial interplay: Taste (gustation) + Smell (olfaction).
    • Other inputs: Texture, temperature, chemesthesis (e.g., capsaicin).
  • Key Disorders:
    • Ageusia: Total taste loss.
    • Hypogeusia: Reduced taste.
    • Dysgeusia: Distorted taste. Gustatory pathway diagram

⭐ The insula and frontal operculum constitute the primary gustatory cortex; lesions can cause significant taste impairment.

High‑Yield Points - ⚡ Biggest Takeaways

  • Olfactory epithelium (superior nasal cavity) houses bipolar receptor neurons using GPCRs.
  • Olfactory pathway largely bypasses thalamus, projecting to piriform cortex & amygdala.
  • Taste buds on fungiform, foliate, circumvallate papillae contain gustatory cells.
  • Five basic tastes: sweet, sour, salty, bitter, umami.
  • Taste transduction: Salty/Sour via ion channels; Sweet/Bitter/Umami via GPCRs.
  • Cranial nerves for taste: CN VII (anterior 2/3 tongue), CN IX (posterior 1/3 tongue), CN X (epiglottis).
  • Gustatory pathway: Nerves → Nucleus Solitarius (medulla) → Thalamus (VPM)Insular cortex (gustatory cortex).

Practice Questions: Physiology of Smell and Taste

Test your understanding with these related questions

Sensory fibers from the taste buds in the back of the tongue and soft palate travel along:

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Flashcards: Physiology of Smell and Taste

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Tone stimulus is used for _____

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Tone stimulus is used for _____

CERA (CERA/BERA)

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