Physiology of Hearing

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Functional Anatomy - Ear's Blueprint

  • Outer Ear:
    • Pinna: Sound localization & collection.
    • External Auditory Canal (EAC): Conducts sound waves to TM; outer 1/3 cartilage, inner 2/3 bone.
  • Middle Ear (Tympanic Cavity): Air-filled.
    • Tympanic Membrane (TM): Vibrates.
    • Ossicles (Malleus, Incus, Stapes): Transmit & amplify vibrations. 📌 MIS
    • Eustachian Tube: Pressure equalization.
  • Inner Ear (Labyrinth): Fluid-filled.
    • Cochlea: Hearing; contains Organ of Corti (hair cells).

Anatomy of the ear showing outer, middle, and inner ear

⭐ The middle ear provides an impedance matching mechanism, amplifying sound pressure by about 22 times from air to cochlear fluid.

Sound Conduction - Journey to Cochlea

  • Outer Ear:
    • Pinna & External Auditory Canal (EAC) collect & channel sound.
    • EAC resonance boosts frequencies around 3 kHz.
  • Middle Ear: (Air-filled)
    • Tympanic Membrane (TM) vibrates.
    • Ossicles (Malleus, Incus, Stapes - 📌 MIS) amplify & transmit vibrations.
    • Impedance matching: Area ratio (TM:Oval Window ≈ 17:1) & lever ratio (ossicles ≈ 1.3:1) → total amplification ≈ 22x.
    • Stapes vibrates against oval window.
  • Inner Ear:
    • Oval window vibrations generate perilymphatic waves (scala vestibuli).

⭐ The middle ear's key role is impedance matching, efficiently transferring sound from air (low impedance) to cochlear fluid (high impedance), minimizing energy loss.

Cochlear Physiology - Dance of Hair Cells

  • Basilar Membrane (BM) Vibration: Sound waves displace BM, creating a traveling wave.
    • Tonotopic organization: High frequencies stimulate BM base; low frequencies stimulate BM apex.
  • Hair Cell (HC) Mechanotransduction:
    • Shearing force between BM & Tectorial Membrane bends stereocilia of HCs.
    • Bending towards kinocilium (tallest stereocilium) opens MET (mechanoelectrical transduction) channels via tip links.
    • K+ influx from K+-rich endolymph (main_tained by Stria Vascularis at +80 mV, the endocochlear potential). 📌 K+ INflux for excitation.
    • HC depolarization → Voltage-gated Ca2+ channels open → Ca2+ influx → Glutamate (neurotransmitter) release → Auditory nerve fiber firing.
  • Outer Hair Cell (OHC) Amplification:
    • OHCs exhibit electromotility (change length via Prestin protein) in response to depolarization.
    • This actively amplifies BM motion, enhancing hearing sensitivity (by ~40-50 dB) and frequency selectivity (cochlear amplifier).

Cochlear hair cell mechanotransduction diagram

⭐ OHCs are responsible for the cochlea's remarkable sensitivity and sharp frequency tuning; their damage leads to significant hearing loss and poor frequency discrimination (e.g., in noise-induced hearing loss).

Auditory Neural Pathway - Brain's Sound Booth

  • 1st Order Neuron: Spiral ganglion cells (cochlea) → Cochlear Nuclei (CN).
  • CN (Pons/Medulla): Ventral & Dorsal nuclei; tonotopic organization maintained.
  • Superior Olivary Complex (SOC - Pons): Binaural processing (sound localization); 1st site of bilateral input.
  • Lateral Lemniscus (LL - Midbrain): Main ascending auditory tract.
  • Inferior Colliculus (IC - Midbrain): Auditory reflex integration; sound orientation.
  • Medial Geniculate Body (MGB - Thalamus): Auditory relay station to cortex.
  • Primary Auditory Cortex (Temporal Lobe): Heschl's gyrus (Brodmann areas 41, 42); conscious sound perception.

📌 Mnemonic: E COLI MA (Ear/Spiral Ganglion → Cochlear Nucleus → Superior Olivary Complex → Lateral Lemniscus → Inferior Colliculus → Medial Geniculate Body → Auditory Cortex)

⭐ The Superior Olivary Complex is the first major site for binaural interaction, crucial for sound localization by comparing interaural time and intensity differences.

Auditory pathway from ear to brain

High‑Yield Points - ⚡ Biggest Takeaways

  • Middle ear performs impedance matching via ossicles, transferring sound from air to fluid.
  • Eustachian tube equalizes middle ear pressure with atmospheric pressure.
  • Inner hair cells (IHCs) are primary auditory sensory receptors; Outer hair cells (OHCs) are cochlear amplifiers.
  • Basilar membrane exhibits tonotopic organization: base for high frequencies, apex for low frequencies.
  • Key auditory pathway: Cochlear N.Cochlear NucleiSOC (localization) → ICMGB (thalamus) → Auditory Cortex.

Practice Questions: Physiology of Hearing

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Malleus and incus are derived from?

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Flashcards: Physiology of Hearing

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A normal person or one with sensorineural hearing loss hears _____ when the ear canal is occluded and softer when the canal is open (Bing positive)

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A normal person or one with sensorineural hearing loss hears _____ when the ear canal is occluded and softer when the canal is open (Bing positive)

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