Otoacoustic Emissions

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OAE Basics - Cochlear Whispers

  • Low-intensity sounds from cochlea; "cochlear whispers".
  • Indicate healthy Outer Hair Cell (OHC) function.
  • Objective, non-invasive cochlear assessment.
  • Present if hearing better than 30-40 dB HL.
  • Absent/reduced in sensorineural hearing loss affecting OHCs.
  • Types: Spontaneous (SOAEs), Evoked (TEOAEs, DPOAEs). Cochlear Anatomy: Organ of Corti & Hair Cells

⭐ Otoacoustic emissions (OAEs) are sounds generated within the normal cochlea, reflecting active biomechanical processes, primarily from Outer Hair Cells (OHCs).

OAE Types - Sound Varieties

  • Spontaneous OAEs (SOAEs):
    • Sound: Narrow-band tonal emissions.
    • Stimulus: None (spontaneous).
    • Prevalence: ~50% normal hearing.
    • Use: Limited diagnostically.
  • Evoked OAEs (EOAEs): Require external acoustic stimulus.
    • Transient Evoked OAEs (TEOAEs):
      • Stimulus: Brief clicks or tone-pips.
      • Sound: Broadband, wide cochlear activity.
      • Use: Newborn screening, cochlear integrity.
    • Distortion Product OAEs (DPOAEs):
      • Stimulus: Two pure tones ($f_1, f_2$; $f_2 > f_1$).
      • Sound: Intermodulation distortion; key is $2f_1-f_2$.

      ⭐ Distortion Product OAEs (DPOAEs), typically measured at the $2f_1-f_2$ frequency, allow for frequency-specific assessment of cochlear function.

    • Stimulus Frequency OAEs (SFOAEs):
      • Stimulus: Single continuous pure tone.
      • Sound: Emission at stimulus frequency.
      • Use: Rare (measurement issues). Otoacoustic Emissions (OAE) Test Setup

OAE Mechanism - OHC Magic

  • Outer Hair Cells (OHCs): Primary generators of OAEs.
  • Electromotility: OHCs rapidly change length (contract/elongate).
    • Mediated by prestin, a motor protein in OHC lateral wall.
  • Cochlear Amplifier:
    • OHC electromotility amplifies basilar membrane motion for low-intensity sounds (up to 50-60 dB).
    • Sharpens frequency tuning.
  • OAE Generation: This amplified mechanical energy propagates outwards, creating sound detected as OAEs.

⭐ The electromotility of Outer Hair Cells (OHCs), driven by the motor protein prestin, is the primary mechanism behind the cochlear amplifier and OAE generation.

OAE Clinical Use - Diagnostic Clues

  • OAEs Present:
    • Indicates healthy Outer Hair Cell (OHC) function.
    • Suggests patent external & middle ear (or only mild conductive loss).
    • Rules out significant cochlear hearing loss (typically >30-40 dB HL) at test frequencies.
  • OAEs Absent:
    • Suggests OHC dysfunction (cochlear pathology).
    • Or, significant conductive hearing loss (e.g., middle ear effusion, air-bone gap ≥30-35 dB).
    • Requires further audiological assessment (e.g., tympanometry, ABR).
  • Specific Conditions & Clues:
    • Noise-Induced Hearing Loss (NIHL) / Ototoxicity: Early OHC damage detection (OAEs ↓ or absent, often before audiogram changes).
    • Meniere's Disease: OAEs may be variable, reduced, or absent depending on stage.
    • Vestibular Schwannoma: OAEs often present if cochlea and its blood supply are spared.
    • Non-organic/Functional Hearing Loss: Present OAEs with significant reported hearing loss can be a key indicator.

⭐ In Auditory Neuropathy Spectrum Disorder (ANSD), OAEs are typically present, indicating normal OHC function, while Auditory Brainstem Responses (ABR) are absent or severely abnormal.

OAE Interpretation - Reading Signals

  • Present OAEs: Normal outer hair cell (OHC) function.
  • Absent OAEs: OHC dysfunction or conductive loss.
  • SNR Criteria:
    • DPOAEs: ≥ 6 dB SPL.
    • TEOAEs: ≥ 3-4 dB SPL.
  • Reproducibility: >70% for reliable response.
  • Influencers: Cerumen, middle ear fluid, noise.

⭐ The presence of middle ear fluid (otitis media with effusion) is a common cause of absent OAEs, even with normal cochlear function, necessitating middle ear assessment.

High‑Yield Points - ⚡ Biggest Takeaways

  • Otoacoustic Emissions (OAEs) are low-intensity sounds from healthy outer hair cells (OHCs) of the cochlea.
  • Key types: Transient Evoked OAEs (TEOAEs) & Distortion Product OAEs (DPOAEs).
  • Objective, non-invasive assessment of cochlear (OHC) integrity.
  • Crucial for universal newborn hearing screening programs.
  • Requires patent EAC and normal middle ear function for reliable recording.
  • Absent OAEs indicate potential OHC dysfunction or significant middle ear pathology.
  • Present OAEs typically suggest hearing thresholds better than 30-40 dB HL at tested frequencies_._

Practice Questions: Otoacoustic Emissions

Test your understanding with these related questions

A 40-year-old man presents to the general medicine clinic with progressive hearing loss in his right ear, difficulty hearing conversations in noisy places, and occasional ringing in his right ear. He denies any associated symptoms and has a normal otoscopic examination. A Weber's test is performed, and the patient reports hearing the vibration loudest in his left ear. Which of the following findings would most likely be observed in this patient?

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Flashcards: Otoacoustic Emissions

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Acoustic reflex decay is a feature of _____ hearing loss

TAP TO REVEAL ANSWER

Acoustic reflex decay is a feature of _____ hearing loss

retrocochlear (cochlear/retrocochlear)

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