Skeletal System

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Bone Blueprint - Foundation Blocks

  • Composition:
    • Organic (~30%): Collagen Type I (major), proteoglycans, glycoproteins.
    • Inorganic (~70%): Hydroxyapatite crystals $Ca_{10}(PO_4)_6(OH)_2$.
  • Bone Cells:
    • Osteoblasts: Bone formation; synthesize osteoid; ↑Alkaline Phosphatase.
    • Osteocytes: Mature cells in lacunae; mechanosensation, maintain matrix.
    • Osteoclasts: Bone resorption; multinucleated; Howship's lacunae; ↑TRAP (Tartrate-Resistant Acid Phosphatase). 📌 Mnemonic: OsteoBlasts Build, OsteoClasts Carve.
  • Microscopic Types:
    • Lamellar: Mature, organized (compact & spongy bone).
    • Woven: Immature, disorganized (fetal development, fracture repair). Osteoblast and Osteoclast cells
  • Macroscopic Classification: Long, short, flat, irregular, sesamoid.

⭐ Volkmann's canals connect Haversian systems (osteons) and run perpendicular to them, transmitting blood vessels from the periosteum into the bone.

Axial Skeleton - Core Framework

  • 80 bones: Skull (22), Vertebral Column (26), Thoracic Cage (25), Hyoid (1), Auditory Ossicles (6).
  • Skull:
    • Cranium (8): Frontal, Parietal(2), Temporal(2), Occipital, Sphenoid, Ethmoid.
    • Facial (14): Mandible, Maxilla(2), Zygomatic(2), Nasal(2), Lacrimal(2), Palatine(2), Inf. Nasal Concha(2), Vomer.
  • Vertebral Column:
    • Cervical (C1-C7; Atlas C1, Axis C2), Thoracic (T1-T12; articulate ribs), Lumbar (L1-L5; largest).
    • Sacrum (5 fused), Coccyx (4 fused).
    • Primary curves (Thoracic, Sacral), Secondary (Cervical, Lumbar).
  • Thoracic Cage:
    • Sternum: Manubrium, Body, Xiphoid.
    • Ribs (12 pairs): True (1-7), False (8-10), Floating (11-12).
    • Protects organs, aids respiration.

Axial and appendicular skeleton

⭐ Atlas (C1) lacks body & spinous process; allows "yes" head motion via occipital condyle articulation.

Appendicular Skeleton - Limb Levers

Limbs function as levers. Components: Fulcrum (F) joint, Effort (E) muscle insertion, Resistance (R) load.

  • Lever Classes: 📌 FRE 123: Fulcrum (1st), Resistance (2nd), Effort (3rd) in middle.
    • Class 1 (EFR/RFE): F between E & R. E.g., Triceps (elbow ext.), atlanto-occipital jt. MA varies.
    • Class 2 (ERF/FRE): R between F & E. E.g., Plantarflexion (tiptoes). MA > 1 (Force adv.).
    • Class 3 (FER/REF): E between F & R. E.g., Biceps (elbow flex.). MA < 1 (Speed/ROM adv.). Most common.
  • Mechanical Advantage (MA): $MA = L_E / L_R$
    • $L_E$: Effort Arm length (Fulcrum to Effort).
    • $L_R$: Resistance Arm length (Fulcrum to Resistance).

⭐ Most body levers are Class 3: for speed & ROM, not force.

Joint Junctions - Motion & More

  • Classification:
    • Structural: Based on connecting tissues.
      • Fibrous: Dense connective tissue. E.g., Sutures, Syndesmoses, Gomphoses. (Mostly Synarthrosis)
      • Cartilaginous: Cartilage.
        • Primary (Synchondrosis): Hyaline. E.g., Epiphyseal plate. (Synarthrosis)
        • Secondary (Symphysis): Fibrocartilage. E.g., Pubic symphysis. (Amphiarthrosis)
      • Synovial: Joint cavity. E.g., Knee, Shoulder. (Diarthrosis)
    • Functional: Based on degree of movement.
      • Synarthrosis: Immovable.
      • Amphiarthrosis: Slightly movable.
      • Diarthrosis: Freely movable.
  • Synovial Joints:
    • Key Features: Articular (hyaline) cartilage, joint capsule, synovial membrane, synovial fluid.
    • Types: Hinge, Pivot, Ball & Socket, Saddle, Condylar, Plane.
    • Movements: Flexion/Extension, Abduction/Adduction, Rotation, Circumduction. Synovial Joint Cross-Section

Hilton's Law: The nerve innervating a joint also typically innervates the muscles moving that joint and the skin overlying the insertions of these muscles.

High‑Yield Points - ⚡ Biggest Takeaways

  • Patella is the largest sesamoid bone; Stapes is the smallest bone.
  • Pneumatic bones include maxilla, sphenoid, ethmoid, frontal and mastoid.
  • Clavicle and skull vault undergo intramembranous ossification; most long bones use endochondral.
  • Osteoclasts, multinucleated cells in Howship's lacunae, are for bone resorption.
  • Haversian system (Osteon) is compact bone's structural unit; Volkmann's canals connect Haversian canals.
  • Primary cartilaginous joints (synchondrosis) have hyaline cartilage; secondary (symphysis) have fibrocartilage.

Practice Questions: Skeletal System

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Intramembranous ossification is seen in which bones?

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Flashcards: Skeletal System

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Branches of the subclavian artery can be remembered with the mnemonic (VIT CD)V - _____I - Internal thoracic (internal mammary) arteryT - Thyrocervical trunkC - Costocervical arteryD - Dorsal scapular artery

TAP TO REVEAL ANSWER

Branches of the subclavian artery can be remembered with the mnemonic (VIT CD)V - _____I - Internal thoracic (internal mammary) arteryT - Thyrocervical trunkC - Costocervical arteryD - Dorsal scapular artery

Vertebral artery

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