Hemoglobin-oxygen binding — Flashcards

Flashcard 1: In normal health, O2 exhibits _____-limited gas exchange

Answer: perfusion

Flashcard 2: Carboxyhemoglobin causes _____ O2-binding capacity

Answer: decreased

Flashcard 3: Why must fetal hemoglobin have a much higher O2 binding affinity than HbA? _____

Answer: Drives O2 diffusion across placenta from mother to fetus

Flashcard 4: Carbon monoxide binds competitively to Hb and with 200-250x _____ affinity than O2

Answer: greater

Flashcard 5: The _____ form of hemoglobin is found in the respiratory tract

Answer: relaxed

Flashcard 6: What is the secondary regulator of cerebral perfusion?

Answer: PO2 - only takes effect during severe hypoxia

Flashcard 7: What is the primary regulator of cerebral perfusion?

Answer: PCO2

Flashcard 8: How long can the brain withstand hypoxia before sustaining irreversible damage?

Answer: 5 minutes

Flashcard 9: COPD, cyanotic congenital heart disease, obstructive sleep apnea, and high altitude cause _____ polycythemia

Answer: physiologic secondary

Extra:  * due to chronic hypoxia Watch Polycythemia [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-myeloid-lymphoid/videos/medical-pathophysiology-myeloid-and-lymphoid-myeloid-disorders-polycythemia?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org?ref=anki 

Flashcard 10: Which zone of the lung has the highest Pao2? _____

Answer: Zone 1

Extra:  Watch associated Bootcamp video [https://app.bootcamp.com/med-school/pulmonology/videos/blood?index=14] https://onlinemeded.org?ref=anki