Drug distribution and protein binding — Flashcards

Drug distribution and protein binding — Flashcards

Drug distribution and protein binding — Flashcards
#1

What compartment is the majority of a drug with medium Vd found in? _____

#2

Does warfarin cross the placenta?_____

#3

Warfarin is _____ by cytochrome P450 and thus has many drug interactions

#4

_____ can disrupt the blood-brain barrier which increases the permeability of medications.

#5

What is the relative volume of distribution (Vd) of a small hydrophilic molecule? _____

#6

Which class of drugs can displace warfarin (and other drugs) from serum albumin?_____

#7

_____ readily crosses the blood-brain barrier, and is used to treat tuberculous meningitis

#8

What is the relative volume of distribution (Vd) of a plasma protein-bound molecule? _____

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