SGLT-2 inhibitors — Flashcards

Flashcard 1: At which site do SGLT2 inhibitors block reabsorption of glucose? _____

Answer: proximal tubule of the nephron

Flashcard 2: SGLT2 inhibitors are contraindicated in patients with _____ insufficiency

Answer: renal

Flashcard 3: ARBs are used to treat hypertension, proteinuria, HF, or diabetic nephropathy in patients intolerant to _____

Answer: ACE inhibitors

Flashcard 4: Canagliflozin, dapagliflozin, and empagliflozin are all examples of _____ inhibitors

Answer: SGLT2

Flashcard 5: SGLT2 inhibitors may cause increased risk of vaginal _____

Answer: candidiasis (yeast infection)

Flashcard 6: mestranol

Answer: estrogen

Extra: hypognadism, ovarian failure, menstrual abnormalities, HRT in postmenopausal women, androgen-dependent prostate cancerestrogen receptor-positive breast cancer, hx DVTbinds estrogen receptorincreased risk of endometrial cancer, vaginal bleeding in postmenopausal women

Flashcard 7: clompihene

Answer: SERM

Extra: infertility and PCOSpartial agonist at estrogen receptor, prevents feedback inhibitionhot flashes, ovarian enlargement, multiple pregnancy, visual disturbances

Flashcard 8: tamoxifen

Answer: SERM

Extra: ER-positive breast cancerantagonist at estrogen receptor; specific for breast tissue

Flashcard 9: raloxifene

Answer: SERM

Extra: osteoporosis (reduces bone resorption)agonist at estrogen receptor; specific to bone

Flashcard 10: progestins

Answer:

Extra: contraception, endometrial cancer, abnormal uterine bleedingbinds progesterone receptor; reduces proliferation of endometrium, thickens cervical mucus