Hormonal contraceptives — Flashcards

Flashcard 1: Combined contraceptives are contraindicated in patients > 35 years old who _____

Answer: smoke

Flashcard 2: Ethinyl estradiol, DES, and mestranol are examples _____ analogs

Answer: estrogen

Flashcard 3: Oral _____ contain high doses of estrogen and progesterone (or progesterone alone) which prevent ovulation via inhibition of FSH and LH

Answer: contraceptives

Flashcard 4: What is the mechanism by which combined contraceptives (progestins + estradiol) act as a contraceptive? _____

Answer: Inhibit ovulation

Flashcard 5: What drug class do mifeprostone and ulipristal belong to?_____

Answer: Anti-progestins

Flashcard 6: mestranol

Answer: estrogen

Extra: hypognadism, ovarian failure, menstrual abnormalities, HRT in postmenopausal women, androgen-dependent prostate cancerestrogen receptor-positive breast cancer, hx DVTbinds estrogen receptorincreased risk of endometrial cancer, vaginal bleeding in postmenopausal women

Flashcard 7: clompihene

Answer: SERM

Extra: infertility and PCOSpartial agonist at estrogen receptor, prevents feedback inhibitionhot flashes, ovarian enlargement, multiple pregnancy, visual disturbances

Flashcard 8: tamoxifen

Answer: SERM

Extra: ER-positive breast cancerantagonist at estrogen receptor; specific for breast tissue

Flashcard 9: raloxifene

Answer: SERM

Extra: osteoporosis (reduces bone resorption)agonist at estrogen receptor; specific to bone

Flashcard 10: progestins

Answer:

Extra: contraception, endometrial cancer, abnormal uterine bleedingbinds progesterone receptor; reduces proliferation of endometrium, thickens cervical mucus