GLP-1 receptor agonists — Flashcards

Flashcard 1: Which type(s) of diabetes may be treated with pramlintide (amylin analogs)? _____

Answer: T1DM and T2DM

Flashcard 2: Do GLP-1 agonists and/or DPP-4 inhibitors cause hypoglycemia as a possible side effect?_____

Answer: No

Flashcard 3: GLP-1 agonists can cause _____ as a possible side effect, as well as nausea and vomiting

Answer: pancreatitis

Flashcard 4: Exenatide and liraglutide are both examples of _____

Answer: GLP-1 agonists

Flashcard 5: GLP-1 agonists and DPP-4 inhibitors cause increased satiety via decreased _____

Answer: gastric emptying

Flashcard 6: mestranol

Answer: estrogen

Extra: hypognadism, ovarian failure, menstrual abnormalities, HRT in postmenopausal women, androgen-dependent prostate cancerestrogen receptor-positive breast cancer, hx DVTbinds estrogen receptorincreased risk of endometrial cancer, vaginal bleeding in postmenopausal women

Flashcard 7: clompihene

Answer: SERM

Extra: infertility and PCOSpartial agonist at estrogen receptor, prevents feedback inhibitionhot flashes, ovarian enlargement, multiple pregnancy, visual disturbances

Flashcard 8: tamoxifen

Answer: SERM

Extra: ER-positive breast cancerantagonist at estrogen receptor; specific for breast tissue

Flashcard 9: raloxifene

Answer: SERM

Extra: osteoporosis (reduces bone resorption)agonist at estrogen receptor; specific to bone

Flashcard 10: progestins

Answer:

Extra: contraception, endometrial cancer, abnormal uterine bleedingbinds progesterone receptor; reduces proliferation of endometrium, thickens cervical mucus