Corticosteroids and mechanisms US Medical PG Flashcards - Medical Study Cards
Master Corticosteroids and mechanisms with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Corticosteroids and mechanisms Flashcard Deck - 10 Cards
Flashcard 1: What is the effect of corticosteroids on neutrophil levels? _____
Answer: Increased (neutrophilia)
Flashcard 2: What class of drugs acts via suppression of NF-kB signaling? _____
Answer: glucocorticoids
Flashcard 3: Glucocorticoids may cause _____ as an adverse GI effect
Answer: peptic ulcers (specific)
Flashcard 4: Which antifungal inhibits cortisol production?_____
Answer: Ketoconazole
Flashcard 5: Glucocorticoids are useful for treating _____ disorders (e.g. gout, rheumatoid arthritis, asthma, IBD)
Answer: inflammatory
Flashcard 6: Fluoroquinolone risk of tendon and cartilage damage is increased with concurrent _____ use
Answer: corticosteroid (ie: prednisone)
Flashcard 7: Glucocorticoids inhibit production of inflammatory _____ by cyclooxygenase
Answer: prostaglandins
Flashcard 8: mestranol
Answer: estrogen
Extra: hypognadism, ovarian failure, menstrual abnormalities, HRT in postmenopausal women, androgen-dependent prostate cancer estrogen receptor-positive breast cancer, hx DVT binds estrogen receptor increased risk of endometrial cancer, vaginal bleeding in postmenopausal women
Flashcard 9: clompihene
Answer: SERM
Extra: infertility and PCOS partial agonist at estrogen receptor, prevents feedback inhibition hot flashes, ovarian enlargement, multiple pregnancy, visual disturbances
Flashcard 10: tamoxifen
Answer: SERM
Extra: ER-positive breast cancer antagonist at estrogen receptor; specific for breast tissue
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