Antithyroid medications — Flashcards

Flashcard 1: Which thyroid medications are associated with aplastic anemia?_____

Answer: Propylthiouracil (PTU) and methimazole

Flashcard 2: _____ is a thioamide that works by inhibiting Thyroid peroxidase ONLY

Answer: Methimazole

Flashcard 3: Which thyroid medications can cause agranulocytosis?_____

Answer: PTU and Methimazole

Flashcard 4: _____ occurs when a patient being given high dose potassium iodide (Lugol's solution) develops thyrotoxicosis as an adverse effect.

Answer: Jod-Basedow phenomenon

Flashcard 5: Propranolol is a -blocker that is useful for the treatment of _____ storm

Answer: thyroid

Flashcard 6: Iodinated Radioconstrast Dyes can be used to suppress the peripheral conversion of T4 to T3 via inhibition of _____.

Answer: 5'-deiodinase

Flashcard 7: mestranol

Answer: estrogen

Extra: hypognadism, ovarian failure, menstrual abnormalities, HRT in postmenopausal women, androgen-dependent prostate cancerestrogen receptor-positive breast cancer, hx DVTbinds estrogen receptorincreased risk of endometrial cancer, vaginal bleeding in postmenopausal women

Flashcard 8: clompihene

Answer: SERM

Extra: infertility and PCOSpartial agonist at estrogen receptor, prevents feedback inhibitionhot flashes, ovarian enlargement, multiple pregnancy, visual disturbances

Flashcard 9: tamoxifen

Answer: SERM

Extra: ER-positive breast cancerantagonist at estrogen receptor; specific for breast tissue

Flashcard 10: raloxifene

Answer: SERM

Extra: osteoporosis (reduces bone resorption)agonist at estrogen receptor; specific to bone