Pharmacokinetic interaction mechanisms — Flashcards

Chronic alcohol use leads to _____ of CYP-450

-azoles (antifungals) are _____ of CYP-450

Phenobarbital is an _____ of CYP-450

Warfarin is _____ by cytochrome P450 and thus has many drug interactions

What type of drug interaction is the effect of substance A and B together is greater than the sum of their individual products?_____

Phenytoin is an _____ of CYP-450

Dyslipidemia drugs _____ bind bile acids in the intestinal lumen, preventing absorption and recycling to the liver

Isoniazid _____ cytochrome p450 (induces or inhibits)

What is the treatment for overdose of drugs that act as weak bases (e.g. amphetamines, TCAs)?_____

thalidomide