Positive inotropic agents — Flashcards

Flashcard 1: Cardiac glycosides (e.g. digoxin) exert their effects via inhibition of the _____ pump

Answer: Na+-K+ ATPase

Flashcard 2: Cardiac glycosides (e.g. digoxin) cause _____ cardiac contractility due to increased sarcoplasmic Ca2+ stores

Answer: increased

Flashcard 3: Unlike phenylephrine, norepinephrine causes increased _____ due to 1 activation which results in increased pulse pressure

Answer: cardiac contractility

Flashcard 4: The following drugs are good for Hypertension and Heart Failure as they help prevent _____ACE inhibitors, Beta-blockers (compensated HF), and Aldosterone Antagonists

Answer: cardiac remodeling

Flashcard 5: What sympathomimetic is used to treat cardiogenic shock? _____

Answer: Dobutamine

Flashcard 6: What effect does milrinone have on cardiac contractility? _____

Answer: Increased contractility

Flashcard 7: Dopamine may be used for the treatment of _____ failure and unstable bradycardia

Answer: heart

Flashcard 8: vardenafil

Answer: PDE5 inhibitor

Extra: erectile dysfunctionpatients taking nitrates (lethal hypotension)inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosumheadache, flushing, impaired blue-green color vision, hypotension, dyspepsia

Flashcard 9: sildenafil

Answer: PDE5 inhibitor

Extra: erectile dysfunctionpatients taking nitrates (lethal hypotension)inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosumheadache, flushing, impaired blue-green color vision, hypotension, dyspepsia

Flashcard 10: aspirin

Answer:

Extra: increases permeability of the mitochondrial membrane (incomplete)inhibit oxidative phosphorylation