Class IV antiarrhythmics (calcium channel blockers) — Flashcards

Flashcard 1: Calcium Channel Blockers (CCBs) Diltiazem has some vaso-_____ activity

Answer: dilatory

Flashcard 2: Class I antiarrhythmics exert their actions by blocking _____ channels

Answer: Na+

Flashcard 3: What calcium channel blocker may be combined with nitrates, producing similar effects to -blockers?_____

Answer: Verapamil

Flashcard 4: Which Ca2+ channel blocker has the most potent effects on cardiac muscle? _____

Answer: Verapamil

Flashcard 5: Calcium Channel Blockers (CCBs) Which Ca2+ channel blockers (2) have the most potent effects on vascular smooth muscle? _____

Answer: Amlodipine, Nifedipine

Flashcard 6: Verapamil and diltiazem are both examples of _____ Ca2+ channel blockers

Answer: non-dihydropyridine

Flashcard 7: vardenafil

Answer: PDE5 inhibitor

Extra: erectile dysfunctionpatients taking nitrates (lethal hypotension)inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosumheadache, flushing, impaired blue-green color vision, hypotension, dyspepsia

Flashcard 8: sildenafil

Answer: PDE5 inhibitor

Extra: erectile dysfunctionpatients taking nitrates (lethal hypotension)inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosumheadache, flushing, impaired blue-green color vision, hypotension, dyspepsia

Flashcard 9: aspirin

Answer:

Extra: increases permeability of the mitochondrial membrane (incomplete)inhibit oxidative phosphorylation

Flashcard 10: ouabain

Answer:

Extra: inhibits Na+-K+ ATPase by binding to K+ site