Herpesvirus antivirals — Flashcards

Flashcard 1: Ganciclovir and Valganciclovir are used as prophylaxis of CMV retinitis in the _____

Answer: immunocompromised

Flashcard 2: Which two antiviral drugs directly inhibit DNA polymerase?_____

Answer: Foscarnet and Cidofovir

Flashcard 3: Acyclovir, famciclovir and valacyclovir are all _____ analogs

Answer: guanosine

Flashcard 4: Cidofovir (a CMV retinitis drug) is administered with probenecid and IV saline to _____

Answer: reduce nephrotoxicity

Flashcard 5: Which viral enzyme monophosphorylates Acyclovir/Famciclovir/Valacyclovir, thereby activating it?_____

Answer: Thymidine kinase

Flashcard 6: What is the treatment for CMV retinitis in immunocompromised patients when Ganciclovir fails?_____

Answer: Foscarnet or Cidofovir

Flashcard 7: amantadine

Answer:

Extra: Parkinson's disease, influenza A, rubellaexact mechanism unclear, but leads to increased dopamine releaseataxia

Flashcard 8: NRTIs and _____ both are reverse transcriptase inhibitors used in the treatment of HIV

Answer: NNRTIs

Extra:    https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki 

Flashcard 9: Enfuvirtide binds _____ of HIV inhibiting viral cell fusion with host cells

Answer: gp41

Extra:   Watch Maraviroc, fusion inhibitors, integrase inhibitors [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-antimicrobials/videos/medical-pharmacology-antimicrobials-antivirals-hiv-maraviroc-fusion-inhibitors-integrase-inhibitors?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki 

Flashcard 10: _____ insert themselves into the DNA of the reverse transcriptase, halting further elongation

Answer: NRTIs

Extra:    https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki