Hepatitis C direct-acting antivirals — Flashcards

Flashcard 1: _____, tenofovir, and IFN-alpha can be used to treat HBV

Answer: Lamivudine

Flashcard 2: Sofosbuvir and simeprevir are not used as monotherapies for HCV, but rather as part of a regimen including _____

Answer: ribavirin +/- pegylated-interferon alpha

Flashcard 3: Which type of HAART drug is abacavir (ABC)?_____

Answer: NRTI

Flashcard 4: Highly active antiretroviral therapy (HAART) consists of a minimum of _____ drugs to prevent resistance

Answer: 3

Flashcard 5: Which type of HAART drug is Efavirenz?_____

Answer: NNRTI

Flashcard 6: Which hepatitis drug has myelosuppression as a possible side effect?_____

Answer: Interferon alpha

Flashcard 7: NS3/NS4A protease inhibitors and NS5A inhibitors are under clinical investigation to develop HCV treatment regimens that do not require _____ administration

Answer: interferon/ribavirin

Flashcard 8: In addition to hepatitis C, what other virus is ribavirin classically used to treat?_____

Answer: respiratory syncytial virus (RSV)

Flashcard 9: amantadine

Answer:

Extra: Parkinson's disease, influenza A, rubellaexact mechanism unclear, but leads to increased dopamine releaseataxia

Flashcard 10: Enfuvirtide binds _____ of HIV inhibiting viral cell fusion with host cells

Answer: gp41

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