Broad-spectrum antivirals — Flashcards

Flashcard 1: Cidofovir is an antiviral drug that is _____-toxic

Answer: nephro

Flashcard 2: Which two antiviral drugs directly inhibit DNA polymerase?_____

Answer: Foscarnet and Cidofovir

Flashcard 3: Cidofovir (a CMV retinitis drug) is administered with probenecid and IV saline to _____

Answer: reduce nephrotoxicity

Flashcard 4: The backbone of Highly active antiretroviral therapy (HAART) are _____ such as Ziduvodine

Answer: NRTIs

Flashcard 5: What is the MOA of Cidofovir?_____

Answer: Preferential direct inhibition of viral DNA polymerase

Flashcard 6: NS3/NS4A protease inhibitors and NS5A inhibitors are under clinical investigation to develop HCV treatment regimens that do not require _____ administration

Answer: interferon/ribavirin

Flashcard 7: In addition to hepatitis C, what other virus is ribavirin classically used to treat?_____

Answer: respiratory syncytial virus (RSV)

Flashcard 8: amantadine

Answer:

Extra: Parkinson's disease, influenza A, rubellaexact mechanism unclear, but leads to increased dopamine releaseataxia

Flashcard 9: NRTIs and _____ both are reverse transcriptase inhibitors used in the treatment of HIV

Answer: NNRTIs

Extra:    https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki 

Flashcard 10: Enfuvirtide binds _____ of HIV inhibiting viral cell fusion with host cells

Answer: gp41

Extra:   Watch Maraviroc, fusion inhibitors, integrase inhibitors [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-antimicrobials/videos/medical-pharmacology-antimicrobials-antivirals-hiv-maraviroc-fusion-inhibitors-integrase-inhibitors?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki