Antiretroviral resistance — Flashcards

Flashcard 1: Which type of HAART drug is Dolutegravir?_____

Answer: Integrase inhibitor

Flashcard 2: Which class of HAART drugs compete with nucleotides for binding to HIV reverse transcriptase?_____

Answer: NRTIs

Flashcard 3: Highly active antiretroviral therapy (HAART) consists of a minimum of _____ drugs to prevent resistance

Answer: 3

Flashcard 4: Resistance in CMV to ganciclovir occurs with mutations in the _____ gene

Answer: UL97

Flashcard 5: Which classes of drugs inhibit HIV RNA to dsDNA formation?_____

Answer: NRTIs and NNRTIs

Flashcard 6: Which class of drugs inhibits HIV DNA integration into host cell genomes?_____

Answer: Integrase inhibitors

Flashcard 7: amantadine

Answer:

Extra: Parkinson's disease, influenza A, rubellaexact mechanism unclear, but leads to increased dopamine releaseataxia

Flashcard 8: NRTIs and _____ both are reverse transcriptase inhibitors used in the treatment of HIV

Answer: NNRTIs

Extra:    https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki 

Flashcard 9: Enfuvirtide binds _____ of HIV inhibiting viral cell fusion with host cells

Answer: gp41

Extra:   Watch Maraviroc, fusion inhibitors, integrase inhibitors [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-antimicrobials/videos/medical-pharmacology-antimicrobials-antivirals-hiv-maraviroc-fusion-inhibitors-integrase-inhibitors?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki 

Flashcard 10: _____ insert themselves into the DNA of the reverse transcriptase, halting further elongation

Answer: NRTIs

Extra:    https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki