Topical antifungal agents — Flashcards

Flashcard 1: Which polyene can treat oral and vaginal candidiasis?_____

Answer: Nystatin

Flashcard 2: Azoles are a class of antifungals that can cause _____-toxicity

Answer: hepato

Flashcard 3: Which class of antifungals inhibit a cytochrome p450 enzyme (14-demethylase)?_____

Answer: Azoles

Flashcard 4: -azoles (antifungals) are _____ of CYP-450

Answer: inhibitors

Flashcard 5: For more severe Tinea infections or persistent Onychomycosis (manifestations of dermatophytes), oral _____ is used

Answer: Griseofulvin

Flashcard 6: What is the mainstay treatment for dermatophytes/Tinea infections?_____

Answer: Topical -azoles (clotrimazole)

Flashcard 7: ketoconazole

Answer: antiandrogen

Extra: hirsutism of PCOSgeneral inhibition of steroid synthesisgynecomastian, amenorrhea

Flashcard 8: Griseofulvin inhibits the action of fungal cell _____

Answer: microtubules

Extra:    https://onlinemeded.org/spa/microbiology/fungi/acquire?ref=anki 

Flashcard 9: For more severe Tinea infections or persistent Onychomycosis (manifestations of dermatophytes), oral _____ is used

Answer: Griseofulvin

Extra:   Watch Epidermophyton spp., Trichophyton spp., Microsporum spp. (dermatophytes) [https://dashboard.sketchy.com/study/medical/courses/medical-microbiology/units/medical-microbiology-fungi/videos/medical-microbiology-fungi-cutaneous-mycoses-epidermophyton-spp-trichophyton-spp-microsporum-spp-dermatophytes?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/dermatology/superficial-skin-infections/acquire?ref=anki 

Flashcard 10: Which antifungal agent inhibits fungal protein synthesis? _____

Answer: Flucytosine

Extra:    https://onlinemeded.org/spa/microbiology/fungi/acquire?ref=anki