Antifungal prophylaxis protocols — Flashcards

Flashcard 1: Which class of antifungals inhibit a cytochrome p450 enzyme (14-demethylase)?_____

Answer: Azoles

Flashcard 2: The antifungal class echinocandins can be recognized via the suffix _____

Answer: -fungin (ie: caspofungin)

Flashcard 3: Which drug is used in the chronic maintenence therapy of Cryptococcal meningitis?_____

Answer: Fluconazole

Flashcard 4: Which azole antifungal is especially prone to inhibition of human CYP450?_____

Answer: Voriconazole

Flashcard 5: Which antifungal can result in bone marrow suppression?_____

Answer: Flucytosine

Flashcard 6: Which antifungal prevents candidiasis in patients undergoing hematopoietic stem cell transplant?_____

Answer: Micafungin

Flashcard 7: ketoconazole

Answer: antiandrogen

Extra: hirsutism of PCOSgeneral inhibition of steroid synthesisgynecomastian, amenorrhea

Flashcard 8: Griseofulvin inhibits the action of fungal cell _____

Answer: microtubules

Extra:    https://onlinemeded.org/spa/microbiology/fungi/acquire?ref=anki 

Flashcard 9: For more severe Tinea infections or persistent Onychomycosis (manifestations of dermatophytes), oral _____ is used

Answer: Griseofulvin

Extra:   Watch Epidermophyton spp., Trichophyton spp., Microsporum spp. (dermatophytes) [https://dashboard.sketchy.com/study/medical/courses/medical-microbiology/units/medical-microbiology-fungi/videos/medical-microbiology-fungi-cutaneous-mycoses-epidermophyton-spp-trichophyton-spp-microsporum-spp-dermatophytes?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/dermatology/superficial-skin-infections/acquire?ref=anki 

Flashcard 10: Which antifungal agent inhibits fungal protein synthesis? _____

Answer: Flucytosine

Extra:    https://onlinemeded.org/spa/microbiology/fungi/acquire?ref=anki