Parkinson's disease pathology — Flashcards

Flashcard 1: Niemann Pick disease may present with progressive _____

Answer: neurodegeneration

Flashcard 2: As limb compartment syndrome progresses, patients can develop _____ deficits

Answer: motor

Flashcard 3: Defects in the ubiquitin-proteasome system have been implicated in some cases of juvenile _____ disease

Answer: Parkinson

Flashcard 4: Alzheimer disease is characterized histologically by _____ plaques in gray matter

Answer: neuritic (senile)

Flashcard 5: Alzheimer disease is characterized by _____ of gyri

Answer: narrowing

Flashcard 6: _____ disease is characterized by hypertrophied gastric rugae that resemble brain gyri

Answer: Menetrier

Flashcard 7: Alzheimer disease is characterized by deposition of _____ in the brain, which forms amyloid plaques

Answer: A-amyloid

Flashcard 8: What is the term for infarcted tissue in the basal ganglia or internal capsule caused by occlusion of a lenticulostriate artery?

Answer: lacunar infarct

Flashcard 9: epidural hematoma

Answer: rupture of middle meningeal artery; fracture of temporal bone

Extra: rapid arterial bleedinglucid interval followed by decreased LOC; CN 3 palsy, increased ICPCT: biconvex, hyperdense blood; does not cross sutures; may cross falx, tentorium 

Flashcard 10: central pontine myelinolysis

Answer: often iatrogenic; caused by rapid correction of hyponatremia

Extra: massive axonal demyelination of pontine white matter tractsacute paralysis, dysarthria, dysphagia, diplopia, loss of consciousness; +/- locked-in syndromeT2 MRI: increased signal in central pons