Oncogenes and proto-oncogenes US Medical PG Flashcards - Medical Study Cards
Master Oncogenes and proto-oncogenes with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Oncogenes and proto-oncogenes Flashcard Deck - 10 Cards
Flashcard 1: The Knudson two-hit hypothesis states that _____ copy/copies of a tumor suppressor gene must be knocked out for tumor formation
Answer: both
Flashcard 2: Tumor _____ defines the degree of cellular differentiation and mitotic activity
Answer: grading
Flashcard 3: Mutations in which proto-oncogene can lead to Colon Cancer, Non-Small Cell Lung Adenocarcinoma, and Pancreatic Cancer?_____
Answer: KRAS
Flashcard 4: Which oncogene is associated with Neuroblastoma?_____
Answer: N-myc overexpression
Flashcard 5: What is the mechanism that results in malignancy from the L-MYC oncogene?_____
Answer: amplification
Flashcard 6: What is the associated tumor that results from point mutation of the KIT oncogene?_____
Answer: Gastrointestinal stromal tumor (GIST)
Flashcard 7: fibroma
Answer:
Extra: pulling sensation in groin bundles of spindle-shaped fiibroblasts
Flashcard 8: Brenner tumor
Answer:
Extra: "coffee bean" nuclei on H&E
Solid tumor, tan-yellow color, appears encapsulated. Looks like bladder benign
Flashcard 9: mucinous cystadenocarcinoma
Answer:
Extra: malignant
Flashcard 10: mucinous cystadenoma
Answer:
Extra: multilocular cyst with mucous secreting epithelium benign
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