DNA repair genes and cancer US Medical PG Flashcards - Medical Study Cards
Master DNA repair genes and cancer with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
DNA repair genes and cancer Flashcard Deck - 10 Cards
Flashcard 1: What pathology is characterized by a deficiency of the enzymes used in mismatch base repair? _____
Answer: Lynch syndrome (hereditary nonpolyposis colorectal cancer [HNPCC])
Flashcard 2: Lynch syndrome and some sporadic colorectal carcinomas arise via the _____ instability pathway
Answer: microsatellite
Flashcard 3: Homologous Recombination is defective in breast/ovarian cancers with _____ mutations
Answer: BRCA1/2
Flashcard 4: Which tumor suppressor genes are associated with breast, ovarian, fallopian and pancreatic cancer?_____
Answer: BRCA1/BRCA2
Flashcard 5: Which autosomal dominant syndrome is associated with increased risk for colon, ovarian, and endometrial carcinoma? _____
Answer: Lynch syndrome (HNPCC)
Flashcard 6: What type of gene is the APC gene? _____
Answer: Tumor suppressor gene
Flashcard 7: fibroma
Answer:
Extra: pulling sensation in groin bundles of spindle-shaped fiibroblasts
Flashcard 8: Brenner tumor
Answer:
Extra: "coffee bean" nuclei on H&E
Solid tumor, tan-yellow color, appears encapsulated. Looks like bladder benign
Flashcard 9: mucinous cystadenocarcinoma
Answer:
Extra: malignant
Flashcard 10: mucinous cystadenoma
Answer:
Extra: multilocular cyst with mucous secreting epithelium benign
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