Splenic pathology — Flashcards

Flashcard 1: Which hematologic complication arises from Echinococcus granulosus infection?_____

Answer: Eosinophilia

Flashcard 2: What are the followings in relation to splenomegaly? -Inflammatory infiltration -Myeloproliferative disorder -Passive splenic congestion -Presence of circulating immune complexes -Red pulp hyperplasia -Undegraded metabolite accumulation

Answer: Inflammatory infiltration: could lead to splenomegaly by chronic infections. -Myeloproliferative disorder: splenomegaly by Leukemia & lymphoma. -Passive splenic congestion: Splenomegaly by portal hypertension, splenic vein thrombosis, or congestive heart failure. -Presence of circulating immune complexes: splenomegaly by infective endocarditis. -Red pulp hyperplasia. splenomegaly by removing deform RBC in spleen due to lack of ATP. -Undegraded metabolite accumulation: splenomegaly caused by lysosomal storage diseases ( Nieman pick & gaucher disease) due to accumulation of sphyngomyelin & glucocerebrosides.

Flashcard 3: One hematological pathology that is due to abnormal splicing variants is _____

Answer: -thalassemia

Flashcard 4: Myelofibrosis is often associated with massive _____ due to extramedullary hematopoiesis

Answer: splenomegaly

Flashcard 5: Spherocytes are less able to maneuver through splenic sinusoids and are thus consumed by _____

Answer: splenic macrophages

Flashcard 6: What finding emerges on blood smear following splenectomy in a patient with hereditary spherocytosis? _____

Answer: Howell-Jolly bodies

Flashcard 7: testicular lymphoma

Answer: mets from primary lymphoma

Extra: poor; aggressiveolder men

Flashcard 8: What kinds of tissue samples can be used for karyotyping?

Answer: blood, bone marrow, amniotic fluid, placental tissue